Functions of Chitosan-Ferulic Acid Salt for Prevention of Hypertension

Murata, Yoshifumi; Nagaki, Kumiko; Kofuji, Kyoko; Kishi, Toshihiro

doi:10.3136/fstr.16.437

Cited by 12 publications

(11 citation statements)

References 21 publications

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“…We have previously reported that a weak acid salt of α-CS adsorbs bile acids through electrostatic interactions and that oral administration of the salt reduces serum cholesterol levels in rats [10] [11]. We have also shown that a polymer matrix containing α-CS salt adsorbs bile acids by the same mechanism [12].…”

Section: Introductionmentioning

confidence: 87%

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt

Murata¹,

Kofuji²,

Nishida³

et al. 2014

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Recently, potential applications for β-chitosan (β-CS) have been examined. In the present study, calcium-induced alginate gel beads (Alg-Ca) containing weak acid salts of β-CS were prepared and examined with regard to their ability to adsorb bile acids in vitro. More than 70% of taurocholate dissolved in solution was taken up by Alg-Ca containing 100 mg β-CS, sim. ilar to the degree of uptake observed with Alg-Ca containing α-CS salt. The adsorption of bile acid was affected by the absolute amount of β-CS and/or the acid concentration of the preparation. A secondary bile acid, taurodeoxycholate, was also adsorbed by Alg-Ca containing weak acid salts of β-CS. Therefore, β-CS might be used to adsorb bile acids within the gastrointestinal tract in the same manner as an anion-exchange resin, and thus serve as a complementary means by which to prevent hyperlipidemia.

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Section: Introductionmentioning

confidence: 87%

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt

Murata¹,

Kofuji²,

Nishida³

et al. 2014

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“…85 CH/SA gel beads have been developed to facilitate the intake of FeA by animals (e.g., rats). 86 To achieve this goal, CH/SA beads were prepared by dispersing CH in SA solutions under stirring conditions. This solution was added dropwise into a CaCl 2 solution and left to react for 1 h at room temperature.…”

Section: Films and Hydrogelsmentioning

confidence: 99%

“…CH/FeA salts have been obtained in the form of powder. 86 The pharmacological action of these salts was studied as such and also after being incorporated into calcium-induced alginate beads or pectin beads. These powders were formulated containing different ratios of CH and FeA by placing them in distilled water.…”

Section: Powders and Lyophilizedmentioning

confidence: 99%

“…Employing in vitro tests, two specific functions were possible to be evaluated, the release of FeA from CH/FeA and the adsorption of bile acid by CH/FeA. 86 For this purpose, two media were used, artificial gastric juice and a medium containing bile acid. The first in vitro study was performed in vials containing artificial gastric juice, distilled water, and bile acid, respectively.…”

Section: Powder and Lyophilizedmentioning

confidence: 99%

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Physically Cross-Linked Biopolymer Systems Based on Chitosan and Hydroxycinnamic Acids and Their Food Preservation Application Studies

Corujo

Salum

Herrera

et al. 2022

ACS Food Sci. Technol.

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Production of physically cross-linked biopolymer systems (PCBS) is attracting scientific and industrial attention due to its proven potential for applications in, for example, food, food packaging, food preservation, pharmaceuticals, and cosmetic industries. Its production versatility allows obtaining products in the form of films, powders, lyophilized products, edible coatings, and gel beads, among others. This review presents different methods for obtaining, characterizing, and applying these PCBS designed and produced using chitosan (CH) and hydroxycinnamic acids (HAs), resulting exclusively from noncovalent interactions. Each variable characterizing each component of the PCBS is evaluated, gaining a better understanding of their roles. The influence of different molecular weights, viscosities, and degree of deacetylation among other variables belonging to the biopolymer is presented, while the role of the type, amount, and position of the substituent groups on the HAs is shown using caffeic, ferulic, coumaric, chlorogenic, and rosmarinic acids as physical cross-linkers. The molar ratio between HAs and CH is a key factor when forming PCBS and in determining their final properties. Thus, we provide a comprehensive study of these PCBS obtained using CH and HAs, highlighting their environmental and sustainable aspects. Benefits from a materials standpoint regarding their competitive barrier effects and mechanical and thermal properties are also emphasized, especially toward their food packaging and food preservation applications.

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“…The HPLC system had an LC-6A pump (Shimadzu Co., Kyoto), a packed column (150 mm × 4.6 mm; Cosmosil 5C 18 -MS-II; Nacalai Tesque, Kyoto), and a SPD-6A UV detector (Shimadzu Co.). For determination of FA, HPLC was conducted at an ambient temperature using an eluent containing 10 mmol/L phosphate buffer (pH 4.7) and methanol (8:2) at a flow rate of 0.8 mL/min [20]. The detector wavelength was set as 260 nm, and an eluent comprising 0.1% citric acid and acetonitrile (87:13) was used to quantify CA; the detector wavelength was then set to 280 nm [21].…”

Section: Dissolution Testmentioning

confidence: 99%

Preparation and Characteristics of Film Dosage Form Natural Polysaccharides

Murata

Kofuji²,

Nishida³

et al. 2011

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Functions of Chitosan-Ferulic Acid Salt for Prevention of Hypertension

Abstract: on hypertensive rats were tested. In rats given a diet containing CS-FA or FA, elevation of systolic blood pressure was suppressed compared to the control diet group, but no difference in food intake or body weight was observed between groups.

Cited by 12 publications

References 21 publications

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt

Physically Cross-Linked Biopolymer Systems Based on Chitosan and Hydroxycinnamic Acids and Their Food Preservation Application Studies

Preparation and Characteristics of Film Dosage Form Natural Polysaccharides

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Functions of Chitosan-Ferulic Acid Salt for Prevention of Hypertension

Abstract: on hypertensive rats were tested. In rats given a diet containing CS-FA or FA, elevation of systolic blood pressure was suppressed compared to the control diet group, but no difference in food intake or body weight was observed between groups.

Cited by 12 publications

References 21 publications

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing &lt;i&gt;β&lt;/i&gt;-Chitosan Weak Acid Salt

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing &lt;i&gt;β&lt;/i&gt;-Chitosan Weak Acid Salt

Physically Cross-Linked Biopolymer Systems Based on Chitosan and Hydroxycinnamic Acids and Their Food Preservation Application Studies

Preparation and Characteristics of Film Dosage Form Natural Polysaccharides

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Product

Resources

About

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt

Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt