Functions and underlying mechanisms of miR-650 in human cancers

Abstract

MicroRNAs (miRNAs) are one type of noncoding RNAs that interfere with mRNA translation to downregulate gene expression, which results in posttranscriptional gene silencing. Over the past two decades, miRNAs have been widely reported to impact the progression of malignant tumours by interfering with cancer initiation and progression; therefore, miRNAs represent potential new diagnostic and therapeutic tools. miR-650 is a newly identified miR, and increasing studies have demonstrated that miR-650 plays critical roles in cancer progression, such as mediating the Wnt signalling pathway/AXIN1 (axis inhibition protein 1) axis in hepatocellular carcinoma. Nevertheless, associations between the expression patterns and molecular mechanisms of miR-650 in cancer have not been comprehensively described. In this article, we review the existing evidence regarding the mechanisms by which miR-650 expression is altered and their relation to cancer. Moreover, the promising clinical application of miR-650 for diagnosis and treatment is highlighted.

LncRNA DICER1‐AS1 promotes colorectal cancer progression by activating the MAPK/ERK signaling pathway through sponging miR‐650

“…These include gastric cancer, oral cancer, prostate cancer, and anaplastic thyroid cancer. 34 However, previous studies have reported that in CRC, miR‐650 not only inhibits tumor growth but also promotes tumor progression. For example, miR‐650 was downregulated in CRC as a tumor suppressor.…”

“…It has been previously shown that miR‐650 can function as a tumorigenic miRNA in various solid tumors. These include gastric cancer, oral cancer, prostate cancer, and anaplastic thyroid cancer 34 . However, previous studies have reported that in CRC, miR‐650 not only inhibits tumor growth but also promotes tumor progression.…”