<scp>LncRNA DICER1‐AS1</scp> promotes colorectal cancer progression by activating the <scp>MAPK</scp>/<scp>ERK</scp> signaling pathway through sponging <scp>miR</scp>‐650

Peng, Jie; Ke, Chuanfeng; Yang, Cuiyan; Li, Jiyao; Chen, Qi‐Kui; Xia, Zhen; Xu, Jihao

doi:10.1002/cam4.5550

Cited by 11 publications

(5 citation statements)

References 43 publications

(82 reference statements)

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“…The best-known examples of MAPK/ERK-pathway overactivity come from various cancers in which the activity has been linked to cell proliferation, dedifferentiation, and a lack of apoptosis [ 59 ]. Furthermore, several studies have found that ERK activation in tumor cells leads to enhanced migration capability that can be alleviated by specific MAPK/ERK pathway inhibitors [ 60 – 62 ]. Thus, activated MAPK/ERK signaling could partly contribute to the enhanced mobility of ddR1 + R2 cells inside 3D Matrigel.…”

Section: Discussionmentioning

confidence: 99%

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation

Toriseva,

Björkgren,

Junnila

et al. 2024

Cell. Mol. Life Sci.

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Apart from the androgen receptor, transcription factors (TFs) that are required for the development and formation of the different segments of the epididymis have remained unknown. We identified TF families expressed in the developing epididymides, of which many showed segment specificity. From these TFs, down-regulation of runt related transcription factors (RUNXs) 1 and 2 expression coincides with epithelial regression in Dicer1 cKO mice. Concomitant deletion of both Runx1 and Runx2 in a mouse epididymal epithelial cell line affected cell morphology, adhesion and mobility in vitro. Furthermore, lack of functional RUNXs severely disturbed the formation of 3D epididymal organoid-like structures. Transcriptomic analysis of the epididymal cell organoid-like structures indicated that RUNX1 and RUNX2 are involved in the regulation of MAPK signaling, NOTCH pathway activity, and EMT-related gene expression. This suggests that RUNXs are master regulators of several essential signaling pathways, and necessary for the maintenance of proper differentiation of the epididymal epithelium.

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Section: Discussionmentioning

confidence: 99%

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation

Toriseva,

Björkgren,

Junnila

et al. 2024

Cell. Mol. Life Sci.

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“…The MAPK signalling pathway can transduce extracellular signals into the nucleus and has been reported to regulate the proliferation, apoptosis, migration, invasion, and chemoresistance of colon cancer cells [25][26][27][28]. The RAF/MEK/ERK signal transduction cascade is a classical MAPK pathway that can regulate cell proliferation, motility, and survival in various pathological and physiological processes.…”

Section: Discussionmentioning

confidence: 99%

Dihydroartemisinin Enhances the Effects of Oxaliplatin by Activating PDCD5/ARAF mediated Signal Transduction in Colon Cancer

Peng,

Zheng,

Qiu

et al. 2023

Preprint

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Programmed cell death 5 (PDCD5) has been reported to be expressed at low levels in various types of cancers and can be upregulated and rapidly migrate from the cytoplasm to the nucleus when cell death is induced. It is believed to be an important prognostic marker for the response to cancer therapy. Further study of the molecular mechanism by which PDCD5 exerts its antitumour activity and exploration of low toxicity and high-efficiency drugs targeting PDCD5 may reveal a promising strategy for clinical cancer therapy. In this study, the function and molecular mechanism of PDCD5 in colon tumorigenesis were thoroughly studied. PDCD5 was distributed mainly in nontumor tissues and expressed at low levels in colon cancer tissues, and the expression level of PDCD5 was negatively related to cell proliferation and tumour growth. In addition, PDCD5 expression was positively related to the cytotoxicity of oxaliplatin and dihydroartemisinin (DHA). The molecular mechanism of PDCD5 in colon tumorigenesis was also studied using proteomic analysis, which showed that PDCD5 can downregulate ARAF expression and subsequently impair ARAF/MEK/ERK signal transduction. DHA exerts its antitumour activity via active PDCD5 to suppress the ARAF/MEK/ERK signalling pathway and improve the antitumour effects of oxaliplatin. In summary, DHA can enhance the cytotoxic effects of oxaliplatin by regulating PDCD5 expression and subcellular localization to suppress the ARAF/MEK/ERK signalling pathway.

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“…The DANCR/miR-185-5p/HMGA2 axis is involved in the migration and invasion processes of CRC ( 92 ). The upregulation of DICER1-AS1 promotes CRC migration and invasion by activating the MAPK/ERK signaling pathway through a sponge-like effect on miR-650 ( 93 ). Bin et al.…”

Section: Lncrnas Regulate Invasion and Metastasismentioning

confidence: 99%

The functions and mechanisms of long non-coding RNA in colorectal cancer

Lin,

Zhao,

et al. 2024

Front. Oncol.

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CRC poses a significant challenge in the global health domain, with a high number of deaths attributed to this disease annually. If CRC is detected only in its advanced stages, the difficulty of treatment increases significantly. Therefore, biomarkers for the early detection of CRC play a crucial role in improving patient outcomes and increasing survival rates. The development of a reliable biomarker for early detection of CRC is particularly important for timely diagnosis and treatment. However, current methods for CRC detection, such as endoscopic examination, blood, and stool tests, have certain limitations and often only detect cases in the late stages. To overcome these constraints, researchers have turned their attention to molecular biomarkers, which are considered a promising approach to improving CRC detection. Non-invasive methods using biomarkers such as mRNA, circulating cell-free DNA, microRNA, LncRNA, and proteins can provide more reliable diagnostic information. These biomarkers can be found in blood, tissue, stool, and volatile organic compounds. Identifying molecular biomarkers with high sensitivity and specificity for the early and safe, economic, and easily measurable detection of CRC remains a significant challenge for researchers.

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LncRNA DICER1‐AS1 promotes colorectal cancer progression by activating the MAPK/ERK signaling pathway through sponging miR‐650

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 11 publications

References 43 publications

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation

Dihydroartemisinin Enhances the Effects of Oxaliplatin by Activating PDCD5/ARAF mediated Signal Transduction in Colon Cancer

The functions and mechanisms of long non-coding RNA in colorectal cancer

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