Functioning heterotopic oxyntic mucosa in the rectum

Debas, Haile T.; Chaun, Hugh; Thomson, F B; Soon‐Shiong, Patrick

doi:10.1016/0016-5085(80)90929-4

Cited by 22 publications

(2 citation statements)

References 8 publications

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“…Follow-up may clarify this question. Contrary to the experiences of other authors (7,(28)(29)(30)(31) who have found other associated malformations in the digestive tract. vertebral column.…”

Section: Discussioncontrasting

confidence: 88%

Ectopic Gastric Mucosa in Rectum

Menchaca Marines,

Posselt,

Waag

1988

J. pediatr. gastroenterol. nutr.

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SummaryA 3‐year‐old boy with rectal bleeding and colicky abdominal pain is described in whom heterotopic gastric mucosa in the rectum was found. Increased uptake of 99mTc‐pertechnetate was demonstrated in two sites: rectum and left colon. However, gastric mucosa could be identified by endoscopic and histologic examination in the rectum only. The patient was asymptomatic after the operation and during follow‐up, over 14 months.

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Section: Discussioncontrasting

confidence: 88%

Ectopic Gastric Mucosa in Rectum

Menchaca Marines,

Posselt,

Waag

1988

J. pediatr. gastroenterol. nutr.

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“…Acid secretion of the oxyntic HGM has been demonstrated in response to pentagastrin [ 46 ] or histamine by pH probes [ 26 , 35 ] and by Congo red vital staining [ 26 ]. Active acid secretion has been indirectly demonstrated in five cases in whom an H2-receptor antagonist or proton pump inhibitor (PPI) treatment course achieved healing of the ulcerated HGM itself or the associated ulcer [ 22 , 26 , 53 , 58 , 69 ].…”

Section: Resultsmentioning

confidence: 99%

Heterotopic gastric mucosa in the anus and rectum: first case report of endoscopic submucosal dissection and systematic review

Iacopini

Gotoda

Elisei

et al. 2016

Gastroenterol. Rep.

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Background: Heterotopic gastric mucosa (HGM) is the most reported epithelial heterotopia, but it is very rare in the rectum and anus.Methods: The first case of an asymptomatic adult male with a large nonpolypoid HGM in the low rectum underwent complete resection by endoscopic submucosal dissection (ESD) is reported. The systematic review was based on a comprehensive search of MEDLINE, EMBASE and Google Scholar. Studies on humans were identified with the term ‘heterotopic gastric mucosa in the rectum and /or anus.’Results: The search identified 79 citations, and 72 cases were evaluated comprising the present report. Congenital malformations were observed in 17 (24%) patients; rectal duplication accounted for most of the cases. The HGM was located in the anus and perineal rectum in 25 cases (41%) and low, middle and proximal pelvic rectum in 20 (33%), five (8%) and 11 cases (18%), respectively. Morphology was nonpolypoid in 37 cases (51%), polypoid in 26 cases (36%) and ulcerated in nine cases (13%). Specific anorectal symptoms were reported by 50 (69%) patients of the whole study population, and by 33 (97%) of 34 patients ≤ 18 years. Complications were observed in 23 cases (32%). The HGM was excised in 50 cases (83%). Endoscopic resection was performed in 17 cases (34%); resection was piecemeal in five of 12 lesions ≥15 mm, required argon plasma coagulation in two cases and was associated with residual tissue in two (17%). Intestinal metaplasia and an adenoma with low-grade dysplasia were described in three adults (4%).Discussion: This systematic review shows that the HGM in the rectum and anus may be associated with specific rectal symptoms and serious complications, mainly in the pediatric population, and a risk of malignancy in adults. Its complete excision should be recommended, and the ESD can overcome the technical limits of conventional endoscopic snare resection and avoid unnecessary surgery.

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