Functionally substituted isoxazoles and isothiazoles: Synthesis, palladium(II) complexes and their catalytic activity

Synthesis, X-ray characterization and DFT calculations of a series of 3-substituted 4,5-dichloroisothiazoles

“…Synthesis of heterocycles 1–6 was performed according to known procedures for preparation of 4 H -pyrans and 1,4-dihydropyridines using 4,5-dichloroisothiazole-3-carbaldehyde 27 and commercially available methylene-active components (acetylacetone, malononitrile, ethyl 2-cyanoacetate) as starting materials. Single crystals of 1–6 for XRD analysis were obtained by slow evaporation of their saturated solutions in methanol.…”

“…4,5-Dichloroisothiazole-3-carbaldehyde 7 (ref. 27) and its condensation products with acetoacetic ester, acetylacetone, and cyanoacetic ester 8-10 were chosen to be starting compounds (Scheme 2).…”

Synthesis, characterization, HSA/DNA interactions and antitumor activity of new [Ru(η6-p-cymene)Cl2(L)] complexes

“…properties [32][33][34]. Besides their role in the synthesis of biologically active substances, isothiazoles can serve as ligands for transition metal complexes [31,[35][36][37][38]. Recently, we published the results of our research on syntheses and biology of [Ru(η 6 -pcymene)(R-imidazole)Xn] 2-n complexes [39].…”

A new NBS/oxone promoted one pot cascade synthesis of 2-aminobenzimidazoles/2-aminobenzoxazoles: a facile approach

“…Furthermore, our synthesized 2-aminobenzazoles can act as strong ligands in the design of highly efficient palladium catalysts for cross-coupling reactions in aqueous media similar to other azole heterocycles. [32][33][34][35][36] In an extension of our work on new synthetic tactics, 37,38 our group reports for the first time on the efficient in situ generation of a-bromo cyclohexanone using the administration of NBS: oxone in the presence of PTSA (p-toluenesulfonic acid). This in situ generated 2-bromocyclohexanone (III) when allowed to react with second reactant (either 2a or 2a 0 ) yielded 2-aminobenzazoles 3a-h (Scheme 1) in substantial yields.…”