Functionalized niosomes as a smart delivery device in cancer and fungal infection

Aparajay, Priyadarshi; Dev, Abhimanyu

doi:10.1016/j.ejps.2021.106052

Cited by 74 publications

(57 citation statements)

References 263 publications

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“…In addition, once inside the cells, the pH-responsive nature of the niosomes, as observed in Figure 2, would ensure drug release from inside the niosomal bilayer. The NLCPFA niosomes possessed a greater cytotoxic effect on the cancerous cells; this is most likely due to the interaction of folic acid on the surface of niosomes with folate receptors on the breast cancer cells resulting in an active transport of the niosomes inside the cells [41,49]. The IC 50 values for the free drugs and niosomes formulations are shown in Figure 3C,F (20.94 ± 1.07) for SKBR3 cell in 72 h. In these results a synergic effect was evident when the Let and Cyclo combination was administered, which resulted in a significantly more toxic effect in comparison with each drug alone for both cell lines (p < 0.0001).…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Co-Delivery of Letrozole and Cyclophosphamide via Folic Acid-Decorated Nanoniosomes for Breast Cancer Therapy: Synergic Effect, Augmentation of Cytotoxicity, and Apoptosis Gene Expression

et al. 2021

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Breast cancer is one of the most prevalent causes of cancer mortality in women. In order to increase patient prognosis and survival rates, new technologies are urgently required to deliver therapeutics in a more effective and efficient manner. Niosome nanoparticles have been recently employed as therapeutic platforms capable of loading and carrying drugs within their core for both mono and combination therapy. Here, niosome-based nanoscale carriers were investigated as a targeted delivery system for breast cancer therapy. The platform developed consists of niosomes loaded with letrozole and cyclophosphamide (NLC) and surface-functionalized with a folic-acid-targeting moiety (NLCPFA). Drug release from the formulated particles exhibited pH-sensitive properties in which the niosome showed low and high release in physiological and cancerous conditions, respectively. The results revealed a synergic effect in cytotoxicity by co-loading letrozole and cyclophosphamide with an efficacy increment in NLCPFA use in comparison with NLC. The NLCPFA resulted in the greatest drug internalization compared to the non-targeted formulation and the free drug. Additionally, downregulation of cyclin-D, cyclin-E, MMP-2, and MMP-9 and upregulating the expression of caspase-3 and caspase-9 genes were observed more prominently in the nanoformulation (particularly for NLCPFA) compared to the free drug. This exciting data indicated that niosome-based nanocarriers containing letrozole and cyclophosphamide with controlled release could be a promising platform for drug delivery with potential in breast cancer therapy.

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Section: Cytotoxicity Assaymentioning

confidence: 99%

Co-Delivery of Letrozole and Cyclophosphamide via Folic Acid-Decorated Nanoniosomes for Breast Cancer Therapy: Synergic Effect, Augmentation of Cytotoxicity, and Apoptosis Gene Expression

et al. 2021

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“… Schematic representation of different techniques for preparation of niosomes: ( A ) thin-film hydration, ( B ) hand-shaking, ( C ) ether injection, ( D ) bubble, ( E ) sonication, ( F ) proniosome technology, ( G ) reverse phase evaporation, ( H ) freeze-and-thaw, ( I ) heating, ( J ) dehydration and rehydration and ( K ) microfludics. (Reproduced from [ 48 ] with permission from Elsevier and in accordance with the Creative Commons Attribution License). …”

Section: Figurementioning

confidence: 99%

Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

Witika

Bassey

Demana

et al. 2022

IJMS

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Development of nanomaterials for drug delivery has received considerable attention due to their potential for achieving on-target delivery to the diseased area while the surrounding healthy tissue is spared. Safe and efficiently delivered payloads have always been a challenge in pharmaceutics. Niosomes are self-assembled vesicular nanocarriers formed by hydration of a non-ionic surfactant, cholesterol or other molecules that combine to form a versatile drug delivery system with a variety of applications ranging from topical delivery to targeted delivery. Niosomes have advantages similar to those of liposomes with regards to their ability to incorporate both hydrophilic and hydrophobic payloads. Moreover, niosomes have simple manufacturing methods, low production cost and exhibit extended stability, consequently overcoming the major drawbacks associated with liposomes. This review provides a comprehensive summary of niosomal research to date, including the types of niosomes and critical material attributes (CMA) and critical process parameters (CPP) of niosomes and their effects on the critical quality attributes (CQA) of the technology. Furthermore, physical characterisation techniques of niosomes are provided. The review then highlights recent applications of specialised niosomes in drug delivery. Finally, limitations and prospects for this technology are discussed.

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“…Niosomes improve medication behavior in three ways: the drug clearance is delayed, the drug is protected from the biological environment, and the drug's action is limited to the target site [59]. Furthermore, niosomes are flexible and easily modified due to the functional groups on their hydrophilic heads, and the storage and handling of the surfactants do not necessitate special conditions [60]. Additionally, toxic effects on tissues are reduced when the drugs have a local effect; thus, the use of niosomes for drug administration via transdermal, parenteral, and ocular pathways has been extensively investigated [61,62].…”

Section: Niosomesmentioning

confidence: 99%

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

et al. 2022

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Burn injuries can have a lasting effect on people’s quality of life, as they negatively impact their physical and mental health. Then, they are likely to suffer psychological problems as a result. A serious problem is that deep burns are more challenging to treat due to their slow healing rate and susceptibility to microbial infection. Conventional topical medications used for burn treatment are sometimes ineffective because they cannot optimize their ability of transcutaneous absorption at the targeted site and accelerate healing. However, nanotechnology offers excellent prospects for developing current medical wound therapies and is capable of addressing issues such as low drug stability, water solubility, permeability, and bioavailability. The current review focuses on lipid-based vesicles (vesiculosomes) as an example of advanced delivery systems, showing their potential clinical applications in burn wound management. Vesiculosomes may help overcome impediments including the low bioavailability of active agents, offering the controlled release of drugs, increased drug stability, fewer side effects, and reduced dosing frequency, which will ultimately improve therapeutic efficacy and patient compliance. We discuss the application of various types of vesiculosomes such as liposomes, niosomes, ethosomes, cubosomes, transfersomes, and phytosomes in burn healing therapy, as these demonstrate superior skin penetration compared to conventional burn topical treatment. We also highlight their noteworthy uses in the formulation of natural products and discuss the current status as well as future perspectives of these carriers in burn management. Furthermore, the burn treatment options currently available in the market are also summarized.

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Functionalized niosomes as a smart delivery device in cancer and fungal infection

Cited by 74 publications

References 263 publications

Co-Delivery of Letrozole and Cyclophosphamide via Folic Acid-Decorated Nanoniosomes for Breast Cancer Therapy: Synergic Effect, Augmentation of Cytotoxicity, and Apoptosis Gene Expression

Co-Delivery of Letrozole and Cyclophosphamide via Folic Acid-Decorated Nanoniosomes for Breast Cancer Therapy: Synergic Effect, Augmentation of Cytotoxicity, and Apoptosis Gene Expression

Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications

A Narrative Review of the Potential Roles of Lipid-Based Vesicles (Vesiculosomes) in Burn Management

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