Functionalized nanomaterials for biomedical and agriculture industries

Kanth, P. Chandra; Verma, Sandeep Kumar; Gour, Nidhi

doi:10.1016/b978-0-12-816787-8.00010-7

Cited by 11 publications

(4 citation statements)

References 170 publications

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“…In order to surpass the existing drawbacks of nanomaterials, there has recently been development of innovative functionalized nanomaterials with potential applications in various healthcare domains. For covering the nanoparticle core surface with a capping agent [ 17 ], the surface of nanomaterials can be functionalized using either a covalent modification strategy via a standard organic synthesis procedure or using a noncovalent modification complexation, adsorption process, or grafting strategy [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

et al. 2021

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The biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to evade the host’s immune response under the shelter of a biofilm. Quorum sensing (QS) is the mechanism by which the microbial colonies in a biofilm modulate and intercept communication without direct interaction. Hence, the eradication of biofilms through hindering this communication will lead to the successful management of drug resistance and may be a novel target for antimicrobial chemotherapy. Chitosan shows microbicidal activities by acting electrostatically with its positively charged amino groups, which interact with anionic moieties on microbial species, causing enhanced membrane permeability and eventual cell death. Therefore, nanoparticles (NPs) prepared with chitosan possess a positive surface charge and mucoadhesive properties that can adhere to microbial mucus membranes and release their drug load in a constant release manner. As the success in therapeutics depends on the targeted delivery of drugs, chitosan nanomaterial, which displays low toxicity, can be safely used for eradicating a biofilm through attenuating the quorum sensing (QS). Since the anti-biofilm potential of chitosan and its nano-derivatives are reported for various microorganisms, these can be used as attractive tools for combating chronic infections and for the preparation of functionalized nanomaterials for different medical devices, such as orthodontic appliances. This mini-review focuses on the mechanism of the downregulation of quorum sensing using functionalized chitosan nanomaterials and the future prospects of its applications.

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Section: Introductionmentioning

confidence: 99%

Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

et al. 2021

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“…The use of nanomaterials in agriculture is rapidly expanding, with new applications emerging in areas such as crop protection, nutrient delivery, and soil remediation . Many of these applications require the development of nanomaterials with specific properties, such as enhanced stability, targeted delivery, or improved biocompatibility . Nano-QSAR models can play an important role in the design and development of these new nanomaterials, by predicting the properties and behavior of new materials based on their physicochemical characteristics .…”

Section: Emerging Opportunities Of Nano-qsar In Sustainable Agriculturementioning

confidence: 99%

“…95 Many of these applications require the development of nanomaterials with specific properties, such as enhanced stability, targeted delivery, or improved biocompatibility. 90 Nano-QSAR models can play an important role in the design and development of these new nanomaterials, by predicting the properties and behavior of new materials based on their physicochemical characteristics. 21 These models can anticipate the toxicity of new materials to different organisms or optimize material properties for specific applications.…”

Section: Emerging Opportunities Of Nano-qsar In Sustainable Agriculturementioning

confidence: 99%

Harmonization Risks and Rewards: Nano-QSAR for Agricultural Nanomaterials

Singh,

Shelar,

Rai

et al. 2024

J. Agric. Food Chem.

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This comprehensive review explores the emerging landscape of Nano-QSAR (quantitative structure−activity relationship) for assessing the risk and potency of nanomaterials in agricultural settings. The paper begins with an introduction to Nano-QSAR, providing background and rationale, and explicitly states the hypotheses guiding the review. The study navigates through various dimensions of nanomaterial applications in agriculture, encompassing their diverse properties, types, and associated challenges. Delving into the principles of QSAR in nanotoxicology, this article elucidates its application in evaluating the safety of nanomaterials, while addressing the unique limitations posed by these materials. The narrative then transitions to the progression of Nano-QSAR in the context of agricultural nanomaterials, exemplified by insightful case studies that highlight both the strengths and the limitations inherent in this methodology. Emerging prospects and hurdles tied to Nano-QSAR in agriculture are rigorously examined, casting light on important pathways forward, existing constraints, and avenues for research enhancement. Culminating in a synthesis of key insights, the review underscores the significance of Nano-QSAR in shaping the future of nanoenabled agriculture. It provides strategic guidance to steer forthcoming research endeavors in this dynamic field.

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“…These nanocarriers are capable to provide regulated and gradual release of agrochemicals, allowing for slow absorption of active components. 97,98 Besides, the nanocarriers can be further functionalized with DNA, enzymes, antibodies etc. to enable targeted delivery of active ingredients in agriculture.…”

Section: Functionalization Of Monps and Agricultural Waste Managementmentioning

confidence: 99%