Functionalized MoS₂ Nanosheet‐Based Field‐Effect Biosensor for Label‐Free Sensitive Detection of Cancer Marker Proteins in Solution

Abstract

Label-free MoS(2) nanosheet-based field-effect biosensor detects cancer marker protein Prostate Specific Antigen in real time with high sensitivity and selectivity, exhibiting great potential in point-of-care diagnostics application.

MoS2-coated vertical graphene nanosheet for high-performance rechargeable lithium-ion batteries and hydrogen production

“…MoS 2 , a newly discovered bandgap-adjustable semiconductor, has a typical layered structure composed of three S-Mo-S atomic layers stacked together through weak van der Waals interactions. 1,2 Owing to its structural, electronic and electrochemical features, MoS 2 has been explored as the active material for various devices, including fieldeffect transistors, 3 light-emitting diodes, 4 biosensors, 5 lithium-ion batteries (LIBs) and hydrogen production. [6][7][8][9][10] MoS 2 shows a number of advantageous features when used as the anode of LIBs.…”

Biofunctionalized Nanostructured Zirconia for Biomedical Application: A Smart Approach for Oral Cancer Detection

“…These methods are invasive, time‐consuming, expensive, and labor‐intensive. In this context, biosensors offer a reliable, user‐friendly, increased assay speed, high sensitivity and require low sample volumes 7, 8…”

Recent Trends in Field-Effect Transistors-Based Immunosensors

“…It is evident that a great diversity of disease biomarkers can be detected through immunoFET devices, opening new paths for early-stage diagnosis of serious diseases such as cancer. For instance, prostate specific antigen (PSA), a prostate cancer biomarker, was ultrasensitively detected by using immunoFET devices based on different nanomaterials such as silicon nanowires (SiNW) [47,48], graphene [49], molybdenum disulfide (MoS 2 ) [50,51], etc. The lowest detection limit of PSA was achieved by a FET device based on SiNW (1 fg·mL −1 ) [47].…”

“…The first demonstration of the biofunctionalization of MoS 2 nanosheets for designing a liquid-phase FET biosensor was reported by Wang et al [51]. The authors fabricated a FET device for real-time detection of PSA cancer biomarker.…”

“…The layers are held together by weak van der Waals forces and a pristine MoS2 monolayer presents only ~0.65 nm thick [116]. Unlike graphene, a gapless material, monolayer MoS2 exhibits a direct energy bandgap of ~1.9 eV which lowers leakage current and turns it an emerging material for designing highly sensitive FET biosensors [51,108,117]. Furthermore, the 2D MoS2 semiconductor offers high surface-to-volume ratio, facilitating surface functionalization and doping; high transparency, flexibility, and mechanical strength, making it an appealing material for flexible and transparent biodevices [116].…”