Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Abstract

Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fluid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe 3 O 4 ) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe 3 O 4 @Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic field, the results indicate that Fe 3 O 4 @Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.

Biocompatible Magnetic Colloidal Suspension Used as a Tool for Localized Hyperthermia in Human Breast Adenocarcinoma Cells: Physicochemical Analysis and Complex In Vitro Biological Profile

“…There are three types of hyperthermia reported by the National Cancer Institute ( , accessed on 24 November 2020): local hyperthermia (in which a small area of the tumor tissue is heated), regional hyperthermia (in which large areas of tissue and the whole body are heated), and whole-body hyperthermia. For these hyperthermia treatments, the MIONPs are spread throughout the target tissue via direct injection and then the tissue is exposed to an alternate magnetic field (AMF) that has the property of heat generation by one of the two magnetic relaxation mechanisms [ 30 ]. Salimi and collaborators [ 31 ] applied magnetic hyperthermia as a treatment method in breast cancer using dendrimers formed from a functionalized iron oxide nanoparticle with poly amidoamine.…”

Synthesis and Characterization of Magnetite-Alginate Nanoparticles for Enhancement of Nickel and Cobalt Ion Adsorption from Wastewater

“…Characterization of M-AlgNPs. Figure 1 shows the FTIR spectra of M-AlgNPs, which exhibit three peaks at 635, 589, and 441 cm -1 caused by the vibration of FeO bond in both octahedral and tetrahedral sites of the inverse spinel cubic of Fe 3 O 4 , respectively [14,15]. The peaks at 1623 and 1352 cm -1 were attributed to the stretching of the C=O group in the alginate.…”

Mechanism of N-acetyl-cysteine inhibition on the cytotoxicity induced by titanium dioxide nanoparticles in JB6 cells transfected with activator protein-1

“…Various types of NPs are under development for diagnostic and therapeutic applications in the biomedical field ( 18 , 19 ), yet knowledge about their possible toxicity in living cells remains limited ( 20 ). Furthermore, understanding on the prevention of NP toxicity in living cells is lacking.…”