Functionalized layered double hydroxide nanoparticles as an intelligent nanoplatform for synergistic photothermal therapy and chemotherapy of tumors

Ye, Yuhan; Bremner, David H.; Zhang, Hongmei; Chen, Xia; Lou, Jiadong; Zhu, Li‐Min

doi:10.1016/j.colsurfb.2021.112261

Cited by 15 publications

(9 citation statements)

References 56 publications

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“…Compared with the CS nanoparticles, CS@P could effectively accumulate in the tumor regions, and the fluorescence intensity peaked at 24 h postinjection (Additional file 1 : Fig. S17), which may be attributed to the long blood circulation time of the nanoparticles and enhanced permeability and retention (EPR) effect [ 46 ]. Organs and tumors were harvested at 48 h postinjection for ex vivo fluorescence imaging (Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

Zhou

et al. 2022

J Nanobiotechnol

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Background The efficacy of immune checkpoint blockade (ICB), in the treatment of hepatocellular carcinoma (HCC), is limited due to low levels of tumor-infiltrating T lymphocytes and deficient checkpoint blockade in this immunologically "cool" tumor. Thus, combination approaches are needed to increase the response rates of ICB and induce synergistic antitumor immunity. Methods Herein, we designed a pH-sensitive multifunctional nanoplatform based on layered double hydroxides (LDHs) loaded with siRNA to block the intracellular immune checkpoint NR2F6, together with the asynchronous blockade surface receptor PD-L1 to induce strong synergistic antitumor immunity. Moreover, photothermal therapy (PTT) generated by LDHs after laser irradiation modified an immunologically “cold” microenvironment to potentiate Nr2f6-siRNA and anti-PD-L1 immunotherapy. Flow cytometry was performed to assess the immune responses initiated by the multifunctional nanoplatform. Results Under the slightly acidic tumor extracellular environment, PEG detached and the re-exposed positively charged LDHs enhanced tumor accumulation and cell uptake. The accumulated siRNA suppressed the signal of dual protumor activity in both immune and H22 tumor cells by silencing the NR2F6 gene, which further reduced the tumor burden and enhanced systemic antitumor immunity. The responses include enhanced tumor infiltration by CD4+ helper T cells, CD8+ cytotoxic T cells, and mature dendritic cells; the significantly decreased level of immune suppressed regulator T cells. The therapeutic responses were also attributed to the production of IL-2, IFN-γ, and TNF-α. The prepared nanoparticles also exhibited potential magnetic resonance imaging (MRI) ability, which could serve to guide synergistic immunotherapy treatment. Conclusions In summary, the three combinations of PTT, NR2F6 gene ablation and anti-PD-L1 can promote a synergistic immune response to inhibit the progression of primary HCC tumors and prevent metastasis. This study can be considered a proof-of-concept for the targeting of surface and intracellular immune checkpoints to supplement the existing HCC immunotherapy treatments.

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Section: Resultsmentioning

confidence: 99%

Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

Zhou

et al. 2022

J Nanobiotechnol

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“…Figure 6 a shows the results of a similar study by Zhu’s group, which describes a novel LDH-based multifunctional nanoplatform for co-delivery of anticancer medication, DOX and ICG as a synergistic chemotherapy, in addition to PTT [ 72 ]. Notably, arginine-tryptophan-(D-arginine)-asparagine-arginine (B3int) can target cancer cells and enhance the entry of nanomaterials and B3int into the tumor zone.…”

Section: Design Of Functional Ldh Nanohybrids For Drug Deliverymentioning

confidence: 99%

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

Choi

2023

Nanomaterials

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Two-dimensional nanomaterials, particularly layered double hydroxides (LDHs), have been widely applied in the biomedical field owing to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. Since the first study analyzing intercalative LDHs in 1999, numerous studies have investigated their biomedical applications, including drug delivery and imaging; recent research has focused on the design and development of multifunctional LDHs. This review summarizes the synthetic strategies and in-vivo and in-vitro therapeutic actions and targeting properties of single-function LDH-based nanohybrids and recently reported (from 2019 to 2023) multifunctional systems developed for drug delivery and/or bio-imaging.

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“…For example, the arginine-tryptophan-(D-arginine)asparagine-arginine (B3int) moiety in LDH NPs modified by PEG and B3int interacts selectively with a peptide ligand that is found on the surface of various cancerous tumor cells but not on normal cells. This provided an efficient tumor treatment without targeting normal cells [35]. In another study, surface modification was performed using polyvinyl pyrrolidone (PVP) and L-arginine (L-Arg).…”

Section: Modification Of Layered Double Hydroxidesmentioning

confidence: 99%

“…Furthermore, to enhance dispersion stability and biocompatibility, these nanosheets (NSs) have been modified with PVP or polydopamine [36][37][38]. These surface modifications of LDH are summarized in Table 1 [33,[35][36][37][38][39][40][41][42].…”

Section: Modification Of Layered Double Hydroxidesmentioning

confidence: 99%

Recent advances of layered double hydroxide nanohybrids for photothermal therapy

Park

Choi

2023

Medical Lasers

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Cancer is a leading cause of death worldwide. Therefore, the development of safe and effective cancer therapeutics is highly critical. Photothermal therapy (PTT) has recently emerged as a potential cancer treatment strategy, with layered double hydroxides (LDHs) showing high potential for PTT-based synergistic therapies. This review summarizes the photothermal cancer treatment applications of LDHs reported in the last three years; additionally, we introduce a nanoplatform for cancer diagnosis and treatment. We believe that PTT with/without other therapies, such as gas therapy, could open new frontiers in safe chemotherapy.

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Functionalized layered double hydroxide nanoparticles as an intelligent nanoplatform for synergistic photothermal therapy and chemotherapy of tumors

Cited by 15 publications

References 56 publications

Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

Recent advances of layered double hydroxide nanohybrids for photothermal therapy

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