Functionalized graphene nanosheets with improved dispersion stability and superior paclitaxel loading capacity

Kansara, Vrushti; Patil, Rahul; Tripathi, Rahul; Jha, Prafulla K.; Bahadur, Pratap; Tiwari, Sanjay

doi:10.1016/j.colsurfb.2018.10.016

Cited by 27 publications

(13 citation statements)

References 48 publications

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“…The surface charge of GO and ChrGO was measured by a Malvern Zeta Nano ZS-90 instrument, which is an important parameter of colloidal stability. The higher surface charge density on GO nanosheets creates a more stable colloidal dispersion [ 42 ]. As shown in Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

et al. 2021

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To achieve better antitumour efficacy, it is urgent to improve anticancer drug delivery efficiency in targeting cancer cells. In this work, chitosan-functionalized graphene oxide (ChrGO) nanosheets were fabricated via microwave-assisted reduction, which were employed to the intracellular delivery nanosystem for anticancer drug agent in breast cancer cells. Drug loading and release research indicated that adriamycin can be efficiently loaded on and released from the ChrGO nanosheets. Less drug release during delivery and better biocompatibility of ChrGO/adriamycin significantly improve its safety and therapeutic efficacy in HER2-overexpressing BT-474 cells. Furthermore, ChrGO/adriamycin in combination with trastuzumab exhibited synergistic antitumour activity in BT-474 cells, which demonstrated superior therapeutic efficacy compared with each drug alone. Cells treated with trastuzumab (5 μg/mL) or equivalent ChrGO/adriamycin (5 μg/mL) each elicited 54.5% and 59.5% cell death, respectively, while the combination treatment with trastuzumab and ChrGO/adriamycin resulted in a dramatic 88.5% cell death. The dual-targeted therapy displayed higher apoptosis, indicating superior therapeutic efficacy due to the presence of different mechanisms of action. The combined treatment of ChrGO/adriamycin and trastuzumab in BT-474 cells induced cell cycle arrest and apoptosis, which ultimately led to the death of augmented cancer cells. This work has provided a facile microwave-assisted fabrication of ChrGO as a controlled and targeted intracellular drug delivery nanosystem, which is expected to be a novel promising therapy for treating HER2-overexpressing breast cancer cells.

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Section: Resultsmentioning

confidence: 99%

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

et al. 2021

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“…Modification and functionalization of nanostructures is another strategy to improve the stability and significance of nanomaterials in desired applications. [9] For instance, dispersibility and biomedical applicability of reduced graphene nanosheets were improved by functionalization of carboxyl groups with ethylene diamine and folic acid. [9] Boron Nitride nanosheet (BNNS) with a thickness of one to several atomic layers is a two-dimensional crystalline form of hexagonal boron nitride (h-BN), similar to all-carbon graphene nanosheet.…”

Section: Introductionmentioning

confidence: 99%

Using Quantum Density Functional Theory Methods to Study the Adsorption of Fluorouracil Drug on Pristine and Al, Ga, P and As Doped Boron Nitride Nanosheets

2021

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Fluorouracil (5-FU) is one of the most essential drugs, and widely used to treat different types of cancers. However, direct injection of 5-FU causes many inevitable side effects, and therefore, the design of new and targeted drug delivery methods can reduce such undesirable effects. In the present work, density functional theory methods at B3LYP-D3(BJ)/6-31 g* level of theory were used to study the pristine and Al, Ga, P and As doped monolayer boron nitride (BN) nanosheets, as possible adsorption substrates for modern and targeted nanotechnology based drug delivery methods. Natural bond orbitals and quantum theory of atoms in molecules analyses were further used to reveal the physicochemical nature of the adsorption process. It was found that, adsorption process is endothermic in all studied cases, and the interactions energies are in the range of physisorption for pristine, P and As doped BN nanosheets, whereas, the chemical absorption of the 5-FU on Al and Ga doped nanosheets was obtained with adsorption energies of À 45.7 and À 46.3 kcal/mol, respectively. The calculated solvation energies also show that, the dissolution of the 5-FU/nanosheet complexes in water is more than the pristine nanosheets. The overall results confirm the great potential of the studied nanosheets and specially Al and Ga doped BNNSs as promising drug delivery substances in modern targeted drug delivery methods for 5-FU drug.

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“…21 Graphene is shown to be one of the most promising candidates for the next generation of polymer nanocomposites, a one-atom-thick carbon sheet with special electronic and structural properties. 22 –24 Small amounts of the graphene contribute to substantial improvements in polymer thermal stability: The onset of graphene/polystyrene degradation temperature ( T onset ) is increased by about 60°C at 0.19 wt% graphene load 25 –27 ; using graphene sheets as small as 0.04 wt% leads to a polyethylene T onset rise of 54°C. 28 –30 Therefore, it is imperative to develop new approaches to give polymers with great thermal conductivity and adequate flame retardants.…”

Section: Introductionmentioning

confidence: 99%

Impact of graphene oxide on epoxy resin characteristics

Sabet

Soleimani

Hosseini

et al. 2020

High Performance Polymers

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The incorporation of a small part of graphene oxide (GO) offers an appropriate fire retardant for thermally conductive epoxy (EP) resin composites, which is verified by the upper limiting oxygen index of 24.5% and other standard flame-retardant tests. The smoke production rate, total smoke production (TSP), and the smoke density of EP composites were reduced with additional GO. The increased efficiency of fire resistance and smoke suppression is primarily due to the formation of physical barrier and compactness of the developed GO char layers, serving as an effective barrier layer that increases the fire resistance, and the thermal steadiness of the char layers derives from the effect of GO inclusion. The barrier impact of GO and the limited mobility of polymer chains are crucial factors in increasing thermal stability and reduction of generating dangerous carbon monoxide during burns. The thermal stability increased and the peak heat release rate, total heat release, TSP, and the largest smoke density value reduced to 52.5%, 43.6%, 33.9%, and 44.2%, correspondingly, compared with pure EP. The tensile strength and elongation at break of EP composites were enhanced by 23% and 8.4% compared with pure EP, respectively.

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Functionalized graphene nanosheets with improved dispersion stability and superior paclitaxel loading capacity

Cited by 27 publications

References 48 publications

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

Microwave-Assisted Chitosan-Functionalized Graphene Oxide as Controlled Intracellular Drug Delivery Nanosystem for Synergistic Antitumour Activity

Using Quantum Density Functional Theory Methods to Study the Adsorption of Fluorouracil Drug on Pristine and Al, Ga, P and As Doped Boron Nitride Nanosheets

Impact of graphene oxide on epoxy resin characteristics

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