Functionalized core/shell Nanofibers for the Differentiation of Mesenchymal Stem Cells for Vascular Tissue Engineering

Ezhilarasu, Hariharan; Sadiq, Asif; Ratheesh, Greeshma; Sridhar, Sreepathy; Ramakrishna, Seeram; Hasbi, Ab. Rahim Mohd; Yusoff, Mashitah M.; Jose, Rajan; Venugopal, Jayarama Reddy

doi:10.2217/nnm-2018-0271

Cited by 17 publications

(7 citation statements)

References 47 publications

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“…Hollow nanofibers with adjustable wall thickness can be fabricated by selectively removing the core from as-spun core-shell nanofibers. The core-shell morphology of coaxial electrospun fibers offers the possibility of multifunctional materials, with various functional components put into the two compartments of the concentric structure [24,34,[42][43][44][45][46][47][48][49][50][51][52][53][54].…”

Section: Coaxial Electrospinningmentioning

confidence: 99%

“…In tissue engineering, electrospun nanofiber scaffolds are used to replicate the function of the native extracellular matrix (ECM). Core-shell is a flexible approach with intriguing features for encapsulation of the active component, such as growth factors and drugs in the core of the fiber, which is advantageous in drug delivery and tissue regeneration [42,48,49,53,73,81,[104][105][106][107][108][109].…”

Section: Tissue Engineeringmentioning

confidence: 99%

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Electrospinning: The Technique and Applications

Sharma¹,

James²

2023

Recent Developments in Nanofibers Research

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Electrospinning is a useful and convenient method for producing ultrathin fibers. It has grabbed the scientific community’s interest due to its potential to produce fibers with various morphologies. Numerous efforts have been made by researchers and industrialists to improve the electrospinning setup and the associated techniques in order to regulate the morphology of the electrospun fibers for practical applications. Porous, hollow, helical, aligned, multilayer, core-shell, and multichannel fibers have been fabricated for different applications. This chapter aims to provide readers with a clear understanding of the electrospinning process: its principle, methodology, materials, and applications. The chapter begins with a brief introduction to the history of electrospinning, followed by a discussion of its principle and the basic components of electrospinning setup. The parameters that affect the electrospinning process such as operating parameters and the properties of the material being electrospun are discussed briefly. An overview of the different types of electrospinning technique, capable of producing nanofibers with different morphologies, is also presented. Afterward, the applications of electrospun nanofibers, including their use in biomedical applications, filtration, energy sectors, and sensors applications are discussed succinctly. The perspectives on the challenges, opportunities, and new directions for future development of electrospinning technology are also offered.

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Section: Coaxial Electrospinningmentioning

confidence: 99%

Section: Tissue Engineeringmentioning

confidence: 99%

Electrospinning: The Technique and Applications

Sharma¹,

James²

2023

Recent Developments in Nanofibers Research

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“…Nanofibers have received much attention because of their structural similarity, which closely mimics the native ECM environment [ 51 , 52 ]. Nanofibers promote wound healing by providing characteristics of high surface area to volume ratio, tunable mechanical properties, increased porosity, and ability to encapsulate nanoparticles and bioactive compounds for controlled release, which can support the cells to actively interact with the matrix during functionalization and remodeling [ 53 , 54 ]. Hydrogels are hydrophilic 3D polymer networks with established applications in tissue engineering and drug delivery.…”

Section: Nanoparticle Delivery Of Therapeutic Drugs For Diabetic Wmentioning

confidence: 99%

Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

et al. 2020

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Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing.

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“…Fibrous scaffolds prepared by electrospinning are capable of mimicking the complex structure of a natural extracellular matrix ( Hasan et al, 2014 ; Ingavle and Kent, 2014 ; Kishan and Hernandez, 2017 ; Zong et al, 2018 ; Eilenberg et al, 2020 ), and they have large specific surface areas and a high-porosity microstructures that facilitate cell and nutrient infiltration ( Yin et al, 2020a ; Guo et al, 2022 ). The method of coaxial electrospinning can prepare functional fiber membranes ( Ezhilarasu et al, 2019 ; Johnson et al, 2021 ; Zhang et al, 2021 ). Materials can be loaded inside the fiber to enhance the mechanical properties or regulate material degradation.…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

Jin²,

Fan³

et al. 2023

Front. Bioeng. Biotechnol.

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The cells and tissue in the human body are orderly and directionally arranged, and constructing an ideal biomimetic extracellular matrix is still a major problem to be solved in tissue engineering. In the field of the bioresorbable vascular grafts, the long-term functional prognosis requires that cells first migrate and grow along the physiological arrangement direction of the vessel itself. Moreover, the graft is required to promote the formation of neointima and the development of the vessel walls while ensuring that the whole repair process does not form a thrombus. In this study, poly (l-lactide-co-ε-caprolactone) (PLCL) shell layers and polyethylene oxide (PEO) core layers with different microstructures and loaded with sodium tanshinone IIA sulfonate (STS) were prepared by coaxial electrospinning. The mechanical properties proved that the fiber membranes had good mechanical support, higher than that of the human aorta, as well as great suture retention strengths. The hydrophilicity of the oriented-fiber membranes was greatly improved compared with that of the random-fiber membranes. Furthermore, we investigated the biocompatibility and hemocompatibility of different functional fiber membranes, and the results showed that the oriented-fiber membranes containing sodium tanshinone IIA sulfonate had an excellent antiplatelet adhesion effect compared to other fiber membranes. Cytological analysis confirmed that the functional fiber membranes were non-cytotoxic and had significant cell proliferation capacities. The oriented-fiber membranes induced cell growth along the orientation direction. Degradation tests showed that the pH variation range had little change, the material mass was gradually reduced, and the fiber morphology was slowly destroyed. Thus, results indicated the degradation rate of the oriented-fiber graft likely is suitable for the process of new tissue regeneration, while the random-fiber graft with a low degradation rate may cause the material to reside in the tissue for too long, which would impede new tissue reconstitution. In summary, the oriented-functional-fiber membranes possessing core–shell structures with sodium tanshinone IIA sulfonate/polyethylene oxide loading could be used as tissue engineering materials for applications such as vascular grafts with good prospects, and their clinical application potential will be further explored in future research.

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Functionalized core/shell Nanofibers for the Differentiation of Mesenchymal Stem Cells for Vascular Tissue Engineering

Cited by 17 publications

References 47 publications

Electrospinning: The Technique and Applications

Electrospinning: The Technique and Applications

Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

Preparation and performance of random- and oriented-fiber membranes with core–shell structures via coaxial electrospinning

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