Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary

Yoshida, Koki; Onoe, Hiroaki

doi:10.1038/srep45987

Cited by 45 publications

(22 citation statements)

References 33 publications

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“… 223 Utilization of bevel-tip capillary and syringe pump, heterogeneous core–shell hydrogel microsprings with calcium alginate hydrogel as shell components and functional materials (e.g., magnetic particles, agarose, cell-suspended collagen) as core components were produced. 246 …”

Section: Magnetic Robots In the Making: Fabrication Approachesmentioning

confidence: 99%

Magnetically Driven Micro and Nanorobots

et al. 2021

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Manipulation and navigation of micro and nanoswimmers in different fluid environments can be achieved by chemicals, external fields, or even motile cells. Many researchers have selected magnetic fields as the active external actuation source based on the advantageous features of this actuation strategy such as remote and spatiotemporal control, fuel-free, high degree of reconfigurability, programmability, recyclability, and versatility. This review introduces fundamental concepts and advantages of magnetic micro/nanorobots (termed here as “MagRobots”) as well as basic knowledge of magnetic fields and magnetic materials, setups for magnetic manipulation, magnetic field configurations, and symmetry-breaking strategies for effective movement. These concepts are discussed to describe the interactions between micro/nanorobots and magnetic fields. Actuation mechanisms of flagella-inspired MagRobots (i.e., corkscrew-like motion and traveling-wave locomotion/ciliary stroke motion) and surface walkers (i.e., surface-assisted motion), applications of magnetic fields in other propulsion approaches, and magnetic stimulation of micro/nanorobots beyond motion are provided followed by fabrication techniques for (quasi-)spherical, helical, flexible, wire-like, and biohybrid MagRobots. Applications of MagRobots in targeted drug/gene delivery, cell manipulation, minimally invasive surgery, biopsy, biofilm disruption/eradication, imaging-guided delivery/therapy/surgery, pollution removal for environmental remediation, and (bio)sensing are also reviewed. Finally, current challenges and future perspectives for the development of magnetically powered miniaturized motors are discussed.

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Section: Magnetic Robots In the Making: Fabrication Approachesmentioning

confidence: 99%

Magnetically Driven Micro and Nanorobots

et al. 2021

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“…Magnetic responsive spiral‐shaped hydrogel swimmers (spiral swimmers) were fabricated by a buoyancy‐assisted anisotropic gelation method [ 22,24 ] (see the details in the Supporting Information). Magnetic nanoparticles (10.2% (w/w), particle diameter: ≈10 nm) encapsulated in sodium alginate solution (2% (w/w)) were extruded into calcium chloride (CaCl 2 ) solution (1 m ) at a constant flow rate of 200 μL min −1 via a bevel‐tip capillary (inner diameter: 300 μm and the tip angle: 20°).…”

Section: Figurementioning

confidence: 99%

“…The dimensionless velocity of the fabricated bilayered spiral swimmer was successfully changed by applying the thermal stimuli. Our bilayered spiral swimmers could be characterized using the ability to encapsulate various functional materials, [ 24 ] including other stimuli‐responsive hydrogels. Moreover, complex compartmentalization [ 31,32 ] of the spiral swimmer characterized by a laminar flow inside the capillary can also contribute to the optimization of their internal structure and functionality enhancement.…”

Section: Figurementioning

confidence: 99%

Soft Spiral‐Shaped Microswimmers for Autonomous Swimming Control by Detecting Surrounding Environments

Yoshida

Onoe

2020

Advanced Intelligent Systems

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In nature, most microorganisms have motility, which is essential for their survival or reproduction. To move, some microorganisms have evolved soft spiral‐shaped flagella, which rotate through specialized motors. Many of these microorganisms can change the morphology of their spiral‐shaped flagella to control their motility. Herein, by mimicking these flagella, spiral‐shaped microswimmers are developed for various applications, such as target drug delivery, micro‐object transport, and micro‐fluid manipulation. In previous studies, numerous fabrication methods of spiral‐shaped microswimmers are developed. However, the swimming direction and velocity are controlled only by external systems, such as magnetic fields, because the spiral body is not able to deform. Therefore, this soft spiral‐shaped microswimmer for autonomous swimming control by detecting surrounding stimuli is proposed. The velocity of microswimmer largely depends on the geometry of the microswimmer's body. Through usage of a stimuli‐responsive hydrogel in the microswimmer, the geometry autonomously changes in response to the surrounding stimuli. Using finite‐element simulation, it is revealed that the pattern angle is an important parameter for acceleration/deceleration of the microswimmer. The dimensionless velocity of the fabricated bilayered spiral swimmer changes by deforming the geometry in response to the surrounding thermal stimuli.

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“…(c) Alginate fibers composed of different-colored regions in the length direction. Reproduced from a literature with permission from Nature Publishing Group phologies and producing coiled alginate fibers have been developed by controlling the operation conditions such as the fluid viscosities and flow rates (Tottori and Takeuchi, 2015) or by using a nozzle with a diagonally cut edge (Yoshida and Onoe, 2017). These studies demonstrated the ability of microfluidic systems to dynamically tune the 3D morphology and physicochemical properties of the micrometer-sized hydrogel materials.…”

Section: Production Of Functional Bers With Complex 3dmentioning

confidence: 99%

Multiphase Microfluidic Processes to Produce Alginate-Based Microparticles and Fibers

Yamada

Seki

2018

Journal of Chemical Engineering of Japan

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With the recent developments in micro uidic instruments and devices, various types of micrometer-sized materials have been produced by employing multiphase ow patterns formed in the microchannel. In particular, microparticles and micro bers, which are compatible with biomolecule incorporation or living cell encapsulations, have been gaining signi cant attention as new tools for biochemical analysis, cellular physiological studies, tissue engineering, cell transplantation, and controlled drug delivery. Herein, we introduce recent developments in micro uidic systems to produce alginate-based hydrogel microparticles and micro bers. By utilizing droplet dispersions either in equilibrium or nonequilibrium states, or by employing parallel laminar ows, microengineered functional materials that are di cult to generate using conventional devices and operations can be obtained. New and interesting multiphase phenomena are reviewed, together with the pros and cons of these systems and their applications. Furthermore, the fundamentals of multiphase micro uidics and the materials used to prepare particles and bers are brie y introduced.

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Functionalized core-shell hydrogel microsprings by anisotropic gelation with bevel-tip capillary

Cited by 45 publications

References 33 publications

Magnetically Driven Micro and Nanorobots

Magnetically Driven Micro and Nanorobots

Soft Spiral‐Shaped Microswimmers for Autonomous Swimming Control by Detecting Surrounding Environments

Multiphase Microfluidic Processes to Produce Alginate-Based Microparticles and Fibers

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