Functionalized cell-free scaffolds for bone defect repair inspired by self-healing of bone fractures: A review and new perspectives

Li, Li; Lü, Hongwei; Zhao, Yulan; Luo, Jiangming; Yang, Li; Liu, Wanqian; He, Qi

doi:10.1016/j.msec.2019.01.075

Cited by 73 publications

(59 citation statements)

References 167 publications

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“…Bone defect caused by infection, trauma, tumor, bone joint disease, bone nonunion or delayed union has always been a difficulty in clinical treatment [ 97 , 98 ]. The essence of the treatment should be to strengthen the bone mineralization ability of the defect area and the capacity of osteoblasts to form new bone [ 99 , 100 ]. Although research on the treatment of bone defects has been continuing for more than a century, the treatment method is still limited and the effect is still unsatisfactory, especially for osteoporotic fractures or bone defects caused by aging [ 101 ].…”

Section: The Destination Of Bp Tissue Engineering Application-bone Thmentioning

confidence: 99%

Black phosphorus-based 2D materials for bone therapy

Cheng

Cai

Zhao

et al. 2020

Bioactive Materials

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Since their discovery, Black Phosphorus (BP)-based nanomaterials have received extensive attentions in the fields of electromechanics, optics and biomedicine, due to their remarkable properties and excellent biocompatibility. The most essential feature of BP is that it is composed of a single phosphorus element, which has a high degree of homology with the inorganic components of natural bone, therefore it has a full advantage in the treatment of bone defects. This review will first introduce the source, physicochemical properties, and degradation products of BP, then introduce the remodeling process of bone, and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels, polymer membranes, microspheres, and three-dimensional (3D) printed scaffolds. Finally, we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

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Section: The Destination Of Bp Tissue Engineering Application-bone Thmentioning

confidence: 99%

Black phosphorus-based 2D materials for bone therapy

Cheng

Cai

Zhao

et al. 2020

Bioactive Materials

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“…BTE is based on various combinations of three principal components: biomaterials as scaffolds, regulatory signals such as growth factors (GF), and cells. Recently, the design of functionalized cell-free scaffolds has emerged as a useful tool to overcome current drawbacks linked to cell-based approaches (limited autologous cells, time/cost-intensive cell expansion procedures, relative low cell survival rate, and high risk of immune-rejection) [26]. Strategies of scaffold functionalization involve GF, chemokines, and peptides that are able to activate bone resident cells and promote bone regeneration [26].…”

Section: Bone Tissue Repair: H2s As a Suitable Biological Cue For mentioning

confidence: 99%

“…Recently, the design of functionalized cell-free scaffolds has emerged as a useful tool to overcome current drawbacks linked to cell-based approaches (limited autologous cells, time/cost-intensive cell expansion procedures, relative low cell survival rate, and high risk of immune-rejection) [26]. Strategies of scaffold functionalization involve GF, chemokines, and peptides that are able to activate bone resident cells and promote bone regeneration [26]. These biological cues are usually incorporated into scaffolds via physical adsorption, chemical covalent coupling, and encapsulation [26], and their controlled and site specific release is crucial for the success of tissue engineering strategies.…”

Section: Bone Tissue Repair: H2s As a Suitable Biological Cue For mentioning

confidence: 99%

“…Strategies of scaffold functionalization involve GF, chemokines, and peptides that are able to activate bone resident cells and promote bone regeneration [26]. These biological cues are usually incorporated into scaffolds via physical adsorption, chemical covalent coupling, and encapsulation [26], and their controlled and site specific release is crucial for the success of tissue engineering strategies. Over the past 50 years, several studies aimed at understanding the biological processes which takes place in in vivo models of bone fractures during bone repair [27], particularly in in the presence of bone fractures [28,29], and allowed the identification of several biological cues.…”

Section: Bone Tissue Repair: H2s As a Suitable Biological Cue For mentioning

confidence: 99%

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Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

Gambari

Grigolo

Grassi

2019

IJMS

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The importance of hydrogen sulfide (H2S) in the regulation of multiple physiological functions has been clearly recognized in the over 20 years since it was first identified as a novel gasotransmitter. In bone tissue H2S exerts a cytoprotective effect and promotes bone formation. Just recently, the scientific community has begun to appreciate its role as a therapeutic agent in bone pathologies. Pharmacological administration of H2S achieved encouraging results in preclinical studies in the treatment of systemic bone diseases, such as osteoporosis; however, a local delivery of H2S at sites of bone damage may provide additional opportunities of treatment. Here, we highlight how H2S stimulates multiple signaling pathways involved in various stages of the processes of bone repair. Moreover, we discuss how material science and chemistry have recently developed biomaterials and H2S-donors with improved features, laying the ground for the development of H2S-releasing devices for bone regenerative medicine. This review is intended to give a state-of-the-art description of the pro-regenerative properties of H2S, with a focus on bone tissue, and to discuss the potential of H2S-releasing scaffolds as a support for bone repair.

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“…Chemical functionalization is pursued to modify composition, energy or surface charge to direct and influence cells interaction and adhesion. Finally, biological functionalization is performed with covalent or non-covalent immobilization or conjugation of biomolecules, drugs, growth factors and peptides, which can elicit a specific biological response directing cell behaviours or inhibiting adverse reactions [4,5].…”

Section: Introductionmentioning

confidence: 99%

Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review

et al. 2019

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Background: The success of reconstructive orthopaedic surgery strongly depends on the mechanical and biological integration between the prosthesis and the host bone tissue. Progressive population ageing with increased frequency of altered bone metabolism conditions requires new strategies for ensuring an early implant fixation and long-term stability. Ceramic materials and ceramic-based coatings, owing to the release of calcium phosphate and to the precipitation of a biological apatite at the bone-implant interface, are able to promote a strong bonding between the host bone and the implant. Methods: The aim of the present systematic review is the analysis of the existing literature on the functionalization strategies for improving the implant osteointegration in osteoporotic bone and their relative translation into the clinical practice. The review process, conducted on two electronic databases, identified 47 eligible preclinical studies and 5 clinical trials. Results: Preclinical data analysis showed that functionalization with both organic and inorganic molecules usually improves osseointegration in the osteoporotic condition, assessed mainly in rodent models. Clinical studies, mainly retrospective, have tested no functionalization strategies. Registered trademarks materials have been investigated and there is lack of information about the micro- or nano- topography of ceramics. Conclusions: Ceramic materials/coatings functionalization obtained promising results in improving implant osseointegration even in osteoporotic conditions but preclinical evidence has not been fully translated to clinical applications.

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Functionalized cell-free scaffolds for bone defect repair inspired by self-healing of bone fractures: A review and new perspectives

Cited by 73 publications

References 167 publications

Black phosphorus-based 2D materials for bone therapy

Black phosphorus-based 2D materials for bone therapy

Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

Functionalization of Ceramic Coatings for Enhancing Integration in Osteoporotic Bone: A Systematic Review

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