Functionalized carbon nanotubes: biomedical applications

Vardharajula, Sandhya; Ali, Sk Z; Tiwari, Pooja; Eroğlu, Erdal; Vig, Komal; Dennis, Vida A.; Singh, Shree R.

doi:10.2147/ijn.s35832

Cited by 182 publications

(69 citation statements)

References 155 publications

(215 reference statements)

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“…11 Among nanotechnology-derived materials, carbon nanotubes (CNTs) have stimulated a great interest for biomedical applications because of their unique mechanical, electrical, thermal, and spectroscopic properties. [12][13][14] It is important to note that recent studies showed that the functionalization of CNTs with different approaches increase the biocompatibility and decrease toxicity. [15][16][17][18] Among these studies, Guo et al studied the in vivo toxicity of functionalized multi-walled carbon nanotubes (f-MWCNTs) in mice.…”

Section: Introductionmentioning

confidence: 99%

Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

Assali¹,

Zaid²,

Abdallah³

et al. 2017

IJN

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As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis. The characterization of the nanoantibiotics confirmed the successful covalent functionalization of the SWCNTs with 55% of functionalization as has been observed by thermogravimetric analysis. The release profile revealed that 90% of the loaded ciprofloxacin was released within 2.5 h at pH 7.4 showing a first-order release profile with R 2 >0.99. Interestingly, the results of the antibacterial activity indicated that the functionalized SWCNTs have significant increase in the antibacterial activity against the three strains of bacteria – by 16-fold for Staphylococcus aureus and Pseudomonas aeruginosa and by 8-fold for Escherichia coli – in comparison to the ciprofloxacin free drug. Moreover, the synthesized nanoantibiotic showed high hemocompatibility and cytocompatibility over a wide concentration range.

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Section: Introductionmentioning

confidence: 99%

Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

Assali¹,

Zaid²,

Abdallah³

et al. 2017

IJN

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“…Functionalization of the MWCNTs is of importance for providing dispersion of CNTs in an aqueous solution [7]. The MWCNTs used in the present study were produced using the chemical vapor deposition method, implying that these synthesized CNTs should have open ends and be highly susceptible to chemical reaction [16].…”

Section: Discussionmentioning

confidence: 99%

“…Since their discovery CNTs have been used in many fields, such as in electrical and mechanical applications and for biological and medical purposes [6]. The lack of solubility in aqueous media has been a major technical barrier in biological and biomedical applications, but the recent development of methods to chemically modify and functionalize CNTs has made it possible to dissolve and disperse CNTs in water, making them more suitable materials for biological applications [7]. …”

Section: Introductionmentioning

confidence: 99%

An In Vitro Evaluation of the Biological Effects of Carbon Nanotube-Coated Dental Zirconia

et al. 2013

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The purpose of this study is to evaluate functionalized multiwalled carbon nanotubes (fMWCNTs) as a potential coating material for dental zirconia from a biological perspective: its effect on cell proliferation, viability, morphology, and the attachment of an osteoblast-like cell. Osteoblast-like (Saos-2) cells were seeded on uncoated and fMWCNT-coated zirconia discs and in culture dishes that served as controls. The seeding density was 104 cells/cm2, and the cells were cultured for 6 days. Cell viability, proliferation and attachment of the Saos-2 cells were studied. The results showed that Saos-2 cells were well attached to both the uncoated and the fMWCNT-coated zirconia discs. Cell viability and proliferation on the fMWCNT-coated zirconia discs were almost the same as for the control discs. Better cell attachment was seen on the fMWCNT-coated than on the uncoated zirconia discs. In conclusion, fMWCNTs seem to be a promising coating material for zirconia-based ceramic surfaces to increase the roughness and thereby enhance the osseointegration of zirconia implants.

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“…Alternatively, drugs can adsorb through molecular interactions such as π–π stacking. [57–60] These modifications can improve the solubility, biocompatibility for these hollow materials for biomedical applications.…”

Section: Nanocarriersmentioning

confidence: 99%

Advanced Functional Nanomaterials for Theranostics

Huang

Lovell

2016

Adv Funct Materials

205

135

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Nanoscale materials have been explored extensively as agents for therapeutic and diagnostic (i.e. theranostic) applications. Research efforts have shifted from exploring new materials in vitro to designing materials that function in more relevant animal disease models, thereby increasing potential for clinical translation. Current interests include non-invasive imaging of diseases, biomarkers and targeted delivery of therapeutic drugs. Here, we discuss some general design considerations of advanced theranostic materials and challenges of their use, from both diagnostic and therapeutic perspectives. Common classes of nanoscale biomaterials, including magnetic nanoparticles, quantum dots, upconversion nanoparticles, mesoporous silica nanoparticles, carbon-based nanoparticles and organic dye-based nanoparticles, have demonstrated potential for both diagnosis and therapy. Variations such as size control and surface modifications can modulate biocompatibility and interactions with target tissues. The needs for improved disease detection and enhanced chemotherapeutic treatments, together with realistic considerations for clinically translatable nanomaterials will be key driving factors for theranostic agent research in the near future.

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Functionalized carbon nanotubes: biomedical applications

Cited by 182 publications

References 155 publications

Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

An In Vitro Evaluation of the Biological Effects of Carbon Nanotube-Coated Dental Zirconia

Advanced Functional Nanomaterials for Theranostics

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