Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery

Gao, Lin; Sun, Jihong; Li, Yuzhen

doi:10.1016/j.jssc.2011.05.052

Cited by 68 publications

(43 citation statements)

References 36 publications

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“…1C-b), the (100) peak intensity increased obviously, which is opposite with the observations of NN-MCM41. This would be attributed to the re-assemble process of mesopore structure during the superficial amino functionalization [28], and the same phenomenon was also observed in our previous work by using aspririn as drug model [7]. For drug loaded samples I/NN-BMMs (Fig.…”

Section: Characterization Of Mesoporous Silicassupporting

confidence: 78%

“…As the reverse process of adsorption, the ibuprofen release could be divided into two steps: desorption and diffusion. Firstly, as to the desorption of ibuprofen from the mesoporous surface, the main influence factors is the superficial functionalization of the mesopores [7]. While for the following diffusion process, the composition and the pH values of the release medium are key factors besides the mesoporous structure discussed above.…”

Section: The Influence Of Release Medium On Ibuprofen Releasementioning

confidence: 99%

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Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery

Gao

Sun

Zhang

et al. 2012

Materials Chemistry and Physics

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Section: Characterization Of Mesoporous Silicassupporting

confidence: 78%

Section: The Influence Of Release Medium On Ibuprofen Releasementioning

confidence: 99%

Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery

Gao

Sun

Zhang

et al. 2012

Materials Chemistry and Physics

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“…27 It is indicated that the bimodal mesopores are benecial for unrestricted drug molecules diffusion and therefore lead to a higher loading and a faster releasing than that of MCM-41. 27 It is indicated that the bimodal mesopores are benecial for unrestricted drug molecules diffusion and therefore lead to a higher loading and a faster releasing than that of MCM-41.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive sulphonated mesoporous silica: a comparative drug release study

et al. 2016

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Control of morphology and surface functionalization of mesoporous silica materials have enhanced the biocompatibility of these materials with high surface areas and total pore volumes. The functionalization of mesoporous silica materials with organic moieties exhibited controlled release and molecular recognition capabilities for drug delivery. Design of functional mesoporous silica with various mechanisms of controlled release and introduction of new characteristics is very interesting for the construction of highly selective drug carrier. Loading of procaine hydrochloride drug (PrHy) into functionalized KIT-6-SO 3 H and SBA-15-SO 3 H was investigated by a quartz crystal microbalance (QCM) technique and UV-visible spectroscopy. The release was carefully studied by systematically tuning the pH media at simulating gastric fluid without pepsin (SGF, pH 2) and simulating intestinal fluid without pancreatin (SIF, pH 7.4), as well.

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“…43,44 One example is that it can interact with tetraethoxysilane (TEOS), or can form hydrogen bonds with silica, [45][46][47] for the formation of silica microtubes (SMTs). 48,49 Demonstration of controlled release is provided as an approach to reduce the adverse effects of ASA when used in large doses and for prolonged time, including gastrointestinal system irritation, ulcer, or hemorrhage. CA is easy to dissolve in common solvents and easy to electrospin.…”

Section: Introductionmentioning

confidence: 99%

Controlled‐release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers

Jia

Song

Jin

et al. 2015

J of Applied Polymer Sci

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We report a facile method to synthesize hollow silica microtubes (SMTs) from electrospun cellulose acetate fiber precursors. Specific surface areas of up to 765 m 2 /g (Brunauer-Emmett-Teller) were measured for the SMTs, which had a typical wall thickness of 100 nm and submicron inner diameters. An average pore size of 4.6 nm and pore volume of 0.41 cm 3 /g were derived from Barrett-Joyner-Halenda fitting, whereas Horvath-Kawazoe pore size distribution analysis revealed microporous median pore size and maximum pore volume of 0.7 nm and 0.18 cm 3 /g, respectively. The as-prepared SMTs featuring micro-and mesoporous structures in the walls where amino-functionalized to facilitate a very high drug loading (15% by weight). Drug release profile revealed sustained release rates (79% of acetylsalicylic acid was released after 6 h). It is concluded that the high drug loading and sustained release resulted from the advantageous integration of SMTs' hollow structure and wall mesoporosity. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42562.

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Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery

Cited by 68 publications

References 36 publications

Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery

Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery

pH-Responsive sulphonated mesoporous silica: a comparative drug release study

Controlled‐release drug carriers based hierarchical silica microtubes templated from cellulose acetate nanofibers

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