Functionalized anti-osteoporosis drug delivery system enhances osseointegration of an inorganic–organic bioactive interface in osteoporotic microenvironment

Cui, Yutao; Wang, Zhonghan; Li, Zuhao; Xuan, Jianhua; Yuan, Baoming; Sun, Yu; Peng, Chuangang; Leng, Yangming; Dou, Minghan; Wang, Jincheng; Li, He; Wu, Dankai

doi:10.1016/j.matdes.2021.109753

Cited by 17 publications

(23 citation statements)

References 52 publications

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“…By effectively improving the local bone microenvironment, this implant contains high concentrations of strontium ranelate and simvastatin to enhance osteoporosis patients’ osseointegration [ 87 ]. Recently, an inorganic–organic bioactive interface loaded by a newly-developed anti-osteoporosis drug (technetium methylenediphosphonate, 99Tc-MDP) with an anti-osteoporosis property was constructed [ 88 ]. The substrate was porous Ti alloy that printed in three dimensions (3D) and loaded with organic temperature-sensitive poloxamer 407 hydrogel, as seen in Figure 5 [ 88 ].…”

Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

“…Recently, an inorganic–organic bioactive interface loaded by a newly-developed anti-osteoporosis drug (technetium methylenediphosphonate, 99Tc-MDP) with an anti-osteoporosis property was constructed [ 88 ]. The substrate was porous Ti alloy that printed in three dimensions (3D) and loaded with organic temperature-sensitive poloxamer 407 hydrogel, as seen in Figure 5 [ 88 ]. Since 3D printing was introduced in the field of biotechnology, it has shown excellent ability in the biomedical engineering and pharmaceutical field because of its high adaptability in utilizing various materials, its ability to develop intricate engineering parts, as well as its high efficiency in terms of time and cost [ 89 , 90 ].…”

Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

“… External appearance and representative SEM image of the coated Ti implant, and fabrication of the 99Tc-MDP-loaded hydrogel incorporated bioactive interface (TH/PTI) and its effects of promoting osteogenic differentiation and inhibiting osteoclastogenesis, which results in enhanced osteoporotic bone integration. Reproduce and adapted from [ 88 ] under Creative Commons Attribution 4.0 International License (CC BY 4.0). …”

Section: Figurementioning

confidence: 99%

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Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

Section: Conventional Drug-eluting Implantsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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“…It could be clearly seen in the lower part of Figure 3 C that there was an apparent gap between the bone and the Ti6Al4V scaffold, while the bone combined with the composite scaffold and grew together. Briefly, this composite scaffold could promote osseointegration in ovariectomized rabbits [ 128 ].…”

Section: Local Drug Delivery Systems With Ti-based Implantsmentioning

confidence: 99%

“…Adapted with permission from Ref. [ 128 ]. Copyright 2021, Elsevier; ( D ) the preparation process diagram of SLA/CaCO 3 /AIgR@DA and its potential mechanism of enhancing osteogenesis and anti-bone resorption.…”

Section: Local Drug Delivery Systems With Ti-based Implantsmentioning

confidence: 99%

Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

et al. 2022

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Titanium and its alloys are the most widely applied orthopedic and dental implant materials due to their high biocompatibility, superior corrosion resistance, and outstanding mechanical properties. However, the lack of superior osseointegration remains the main obstacle to successful implantation. Previous traditional surface modification methods of titanium-based implants cannot fully meet the clinical needs of osseointegration. The construction of local drug delivery systems (e.g., antimicrobial drug delivery systems, anti-bone resorption drug delivery systems, etc.) on titanium-based implants has been proved to be an effective strategy to improve osseointegration. Meanwhile, these drug delivery systems can also be combined with traditional surface modification methods, such as anodic oxidation, acid etching, surface coating technology, etc., to achieve desirable and enhanced osseointegration. In this paper, we review the research progress of different local drug delivery systems using titanium-based implants and provide a theoretical basis for further research on drug delivery systems to promote bone–implant integration in the future.

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