Functionalization of arylacetic acids via directing-group-assisted remote meta-C–H activation

Abstract

Herein, we report the first microwave-assisted remote-CH functionalization aided by a simple nitrile directing template. Notably, the present protocol showed broad substrate scope via enabling the meta-CH arylation, acetoxylation, and...

Palladium catalyzed remote-meta-C–H functionalization of aniline scaffolds

“…7–32 Our group is also active in investigating the C–H functionalization at meta -positions of an aromatic molecule with the help of different nitrile-containing templates. 33–37…”

Distal-C–H Functionalization of Biphenyl Scaffolds Assisted by Easily Removable/Recyclable Aliphatic Nitrile Templates

“…In this regard, a seminal study of the application of an end-on nitrile directing group for meta -selective C–H functionalization was reported by Yu et al in 2012 . As a result, numerous research teams have investigated a range of approaches using diverse “directing groups”. − Our lab has also been actively working on creating distal- m -C–H activation techniques recently, employing distinct directing groups; this could allow the m -C–H functionalization of aromatic scaffolds through the use of essentially straightforward and detachable aliphatic/aromatic nitrile templates. − These findings encouraged us to believe that the biphenyl scaffolds would enable remote meta -selective C–H olefination.…”

Access to distal meta-C–H functionalization of arylmethanesulfonic acid derivatives

“…32–34 Recently, our group also invented versatile nitrile directing groups (aliphatic and aromatic), which are reversible/reusable upon C–H activation, followed by subsequent functionalization. 35–38…”

“…[32][33][34] Recently, our group also invented versatile nitrile directing groups (aliphatic and aromatic), which are reversible/reusable upon C-H activation, followed by subsequent functionalization. [35][36][37][38] On the other hand, sulfonic acids are privileged precursors in chemical biology and molecular pharmacology for synthesizing biological probes and protein inhibitors. 39,40 In addition, being a strong acid, sulfonic acid is widely used as a catalyst in many transformations.…”