Distal-C–H Functionalization of Biphenyl Scaffolds Assisted by Easily Removable/Recyclable Aliphatic Nitrile Templates

Abstract

We present here the distal-C−H activation/functionalization of biphenyl scaffolds using aliphatic nitrile templates. The approach has demonstrated good to exclusive meta selectivities over a wide range of olefination and acetoxylation substrates. In addition, bis-olefination has been accomplished in a one-pot, sequential manner. Notably, this technique highlights the diversification of pharmaceuticals and natural products. Consequently, the temporary directing aliphatic template has been recovered quantitively from the coupled product.