Functionality of porous silicon particles: Surface modification for biomedical applications

Gallach, D.; Recio‐Sánchez, Gonzalo; Noval, Álvaro Muñoz; Manso‐Silván, Miguel; Ceccone, Giacomo; Martín-Palma, Raúl J.; Costa, Vicente Torres; Duart, José Manuel Martínez

doi:10.1016/j.mseb.2009.12.001

Cited by 27 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the different surface wettability of Si and nanoPS is of key importance since it will contribute to determining the cell adhesion and migration characteristics. In a previous work 23 the wettability of both surfaces was studied in biological buffer conditions; it was found that the water contact angle decreases drastically from a superhydrophobic behavior (water contact angle = 126°) in the case of Si, to a neat hydrophilic character (water contact angle = 10°) for nanoPS. Moreover, cytotoxicity assays in human mesenchymal stem cells confirmed that porous silicon-based microand nanoparticles do not induce apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control

Torres-Costa¹,

Martínez-Muñoz²,

Sánchez-Vaquero³

et al. 2012

IJN

View full text Add to dashboard Cite

Abstract:The engineering of surface patterns is a powerful tool for analyzing cellular communication factors involved in the processes of adhesion, migration, and expansion, which can have a notable impact on therapeutic applications including tissue engineering. In this regard, the main objective of this research was to fabricate patterned and textured surfaces at micron-and nanoscale levels, respectively, with very different chemical and topographic characteristics to control cell-substrate interactions. For this task, one-dimensional (1-D) and two-dimensional (2-D) patterns combining silicon and nanostructured porous silicon were engineered by ion beam irradiation and subsequent electrochemical etch. The experimental results show that under the influence of chemical and morphological stimuli, human mesenchymal stem cells polarize and move directionally toward or away from the particular stimulus. Furthermore, a computational model was developed aiming at understanding cell behavior by reproducing the surface distribution and migration of human mesenchymal stem cells observed experimentally.

show abstract

Section: Resultsmentioning

confidence: 99%

Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control

Torres-Costa¹,

Martínez-Muñoz²,

Sánchez-Vaquero³

et al. 2012

IJN

View full text Add to dashboard Cite

show abstract

“…1, step 4) as previously illustrated. 20 These particles were exposed to the atmosphere for over 1 h for stabilization of their physico-chemical properties before characterization.…”

Section: Experimental 21 Fabrication Of Hybrid Luminescent/magnetic mentioning

confidence: 99%

“…The efficiency of NPSi-PEG conjugation has been previously demonstrated by using x-ray photoelectron spectroscopy. 20 These show a characteristic spherical shape with typical sizes ranging from 0.5 to 3 microns. In previous works, 31 we determined that porous silicon is composed of rounded Si nanocrystals with characteristic sizes ranging from 20 to 80 Å, embedded into an amorphous matrix and with no preferential orientation.…”

Section: Morphology and Compositionmentioning

confidence: 99%

“…Furthermore, we determined that the size distribution of the nanocrystals can be fitted to a Gaussian distribution centered at about 46 Å. Additionally, it was verified that the spherical shape of the hlmNPs is unaffected by the PEG conjugation process. 20 The composition of pre-tore Co infiltrated NPSi layers was analyzed by EDX in cross sections in order to obtain an estimation of the Co infiltration homogeneity. Figure 2(b) reveals the presence of Si, O, and Co emerging from the NPSi host.…”

Section: Morphology and Compositionmentioning

confidence: 99%

“…15 This property enormously facilitates bioconjugation for targeting or directed delivery 16 and biosensing. 17 Nanostructured porous silicon (NPSi) formed by photoelectrochemical etching 18 has emerged among the functional porous semiconductors, whether as a gas sensor, 19 a photoluminescent probe, 20 or as a therapeutic agent through near infrared irradiation. 21 Furthermore, nanoparticles can be infiltrated into NPSi, thus imparting additional properties to the resulting hybrid system (magnetic metals in NPSi for designing storage devices, 22 or high conductivity transition metals for electronic contacts 23 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications

et al. 2011

View full text Add to dashboard Cite

Abstract. This work describes a novel process for the fabrication of hybrid nanostructured particles showing intense tunable photoluminescence and a simultaneous ferromagnetic behavior. The fabrication process involves the synthesis of nanostructured porous silicon (NPSi) by chemical anodization of crystalline silicon and subsequent in pore growth of Co nanoparticles by electrochemically-assisted infiltration. Final particles are obtained by subsequent sonication of the Co-infiltrated NPSi layers and conjugation with poly(ethylene glycol) aiming at enhancing their hydrophilic character. These particles respond to magnetic fields, emit light in the visible when excited in the UV range, and internalize into human mesenchymal stem cells with no apoptosis induction. Furthermore, cytotoxicity in in-vitro systems confirms their biocompatibility and the viability of the cells after incorporation of the particles. The hybrid nanostructured particles might represent powerful research tools as cellular trackers or in cellular therapy since they allow combining two or more properties into a single particle. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

show abstract

Soft PVC foams: Study of the gelation, fusion, and foaming processes. II. Adipate, citrate and other types of plasticizers

Zoller

Marcilla

2011

J of Applied Polymer Sci

View full text Add to dashboard Cite

Plasticized poly(vinyl chloride) (PVC) is one of the most useful polymeric materials on an industrial scale because of its processability, wide range of obtainable properties, and low cost. PVC plastisols are used in the production of flexible PVC foams. Phthalates are the most used plasticizers for PVC, and in a previous article (part I of this series), we discussed the influence of phthalate ester type plasticizers on the foaming process and on the quality of the foams obtained from the corresponding plastisols. Because the use of phthalate plasticizers has been questioned because of possible health implications, the objective of this work was to undertake a similar study with 11 commercial alternative plasticizers to phthalates. The evolution of the dynamic and extensional viscosity and the interactions and thermal transitions undergone by the plastisols during the heating process were studied. Foams were obtained by rotational molding and were characterized by the determination of their thermomechanical properties, density, and cell size distribution. Correlations were obtained between the molecular weight and structure of the plasticizer and the behavior of the corresponding plastisols. After the characterization of the final foamed product, we concluded that foams of relatively good quality could be prepared with alternative plasticizers for replacing phthalates. Several plasticizers {Mesamoll (alkylsulfonic phenyl ester), Eastman 168 [bis(2-ethylhexyl)-1,4-benzenedicarboxylate], Hexamoll [di(isononyl) cyclohexane-1,2-dicarboxylate], Citroflex A4 acetyl tributyl citrate (ATBC), and Plastomoll (dihexyl adipate)} were found to be interesting alternatives in the production of soft PVC foams because they provided very good quality foams with properties similar to, or even better than, those obtained with phthalate plasticizers.

show abstract

Functionality of porous silicon particles: Surface modification for biomedical applications

Cited by 27 publications

References 20 publications

Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control

Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control

Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications

Soft PVC foams: Study of the gelation, fusion, and foaming processes. II. Adipate, citrate and other types of plasticizers

Contact Info

Product

Resources

About