Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications

Muñoz-Noval, Á.; Sánchez-Vaquero, Vanessa; Torres-Costa, V.; Gallach, D.; Ferro-Llanos, Vicente; Olmedo, José Javier Serrano; Manso‐Silván, Miguel; García–Ruiz, Josefa P.; Pozo, Francisco del; Martín-Palma, Raúl J.

doi:10.1117/1.3533321

Cited by 25 publications

(12 citation statements)

References 45 publications

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“…Also a non-superparamagnetic behavior has been observed for Co deposited within porous silicon particles, but all samples show a low coercivity [62] which indicates a low dispersion of Co within the porous structure offering only weak magnetic crosstalk.…”

Section: Magnetic Response Of Metal Filled Microporous Siliconmentioning

confidence: 82%

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Metal Filled Nanostructured Silicon With Respect to Magnetic and Optical Properties

Granitzer

Rumpf

2020

Front. Phys.

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Within this work the utilization of nanostructured silicon as host material for filling with various magnetic nanostructures is reviewed whereas the magnetic and optical properties of the gained composite systems are elucidated. The metal filling of the pores is mainly performed by electroless deposition or by electrodeposition which is discussed by means of some examples. Furthermore, two different types of porous silicon (PSi) morphology are used for the deposition procedure. On the one hand microporous silicon offering luminescence in the visible range is utilized as template material. It offers a branched morphology with a structure size between 2 and 5 nm. In this case not only the magnetic response is investigated but also the influence of the metal filling on the optical properties. On the other hand mesoporous and macroporous silicon in it's low pore regime is employed which offers straight pores with diameters up to 90 nm. In this case the magnetic response strongly depends on the size, the geometry and the spatial distribution of the metal deposits within the pores. A crucial role plays also the morphology of the porous silicon, especially the distance between adjacent pores which is an important parameter regarding magnetic interactions.

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Section: Magnetic Response Of Metal Filled Microporous Siliconmentioning

confidence: 82%

“…In contrast to the findings above, quenching of the photoluminescence has been reported after Co electrodeposition within porous silicon due to oxidation of the emitting centers. An additional blue emission band around 490 nm occurs due to silanol formation at the surface [62].…”

Section: Optical Properties Of Microporous Siliconmentioning

confidence: 99%

Metal Filled Nanostructured Silicon With Respect to Magnetic and Optical Properties

Granitzer

Rumpf

2020

Front. Phys.

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“…Moreover, cytotoxicity assays in human mesenchymal stem cells confirmed that porous silicon-based microand nanoparticles do not induce apoptosis. 24 Accordingly, the definition of Si/nanoPS surface patterns at microscale level leads to simultaneous chemical and nanotopographic contrasts, which will be subsequently used for the control of cell adhesion and migration.…”

Section: Resultsmentioning

confidence: 99%

Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control

Torres-Costa¹,

Martínez-Muñoz²,

Sánchez-Vaquero³

et al. 2012

IJN

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Abstract:The engineering of surface patterns is a powerful tool for analyzing cellular communication factors involved in the processes of adhesion, migration, and expansion, which can have a notable impact on therapeutic applications including tissue engineering. In this regard, the main objective of this research was to fabricate patterned and textured surfaces at micron-and nanoscale levels, respectively, with very different chemical and topographic characteristics to control cell-substrate interactions. For this task, one-dimensional (1-D) and two-dimensional (2-D) patterns combining silicon and nanostructured porous silicon were engineered by ion beam irradiation and subsequent electrochemical etch. The experimental results show that under the influence of chemical and morphological stimuli, human mesenchymal stem cells polarize and move directionally toward or away from the particular stimulus. Furthermore, a computational model was developed aiming at understanding cell behavior by reproducing the surface distribution and migration of human mesenchymal stem cells observed experimentally.

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“…From the point of view of the development of drug-delivery applications, nanoPS is a material able to carry biomolecules conjugated to drugs for achieving site-specific delivery, thus making nanoPS microparticles suitable candidates for the development of novel drug delivery systems [9][10][11]. However, in most cases the drug does not enter the pores, being then necessary to functionalize the surface of nanoPS.…”

Section: Introductionmentioning

confidence: 99%

Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles

et al. 2012

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A study of the fluorescence and Raman spectra of a new and complex drug delivery system formed by emodin adsorbed on silver nanoparticles embedded into a matrix of porous silicon is here reported. Several experimental methods of inclusion of the drug-silver set inside the pores, without previous functionalization of porous silicon, have been tested in order to optimize the conditions for the fluorescence detection of emodin. In this sense, we have also added bovine serum albumin to the system, finding that the presence of the protein enhances the fluores-cence signal from emodin.

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Hybrid luminescent/magnetic nanostructured porous silicon particles for biomedical applications

Cited by 25 publications

References 45 publications

Metal Filled Nanostructured Silicon With Respect to Magnetic and Optical Properties

Metal Filled Nanostructured Silicon With Respect to Magnetic and Optical Properties

Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control

Development of drug delivery systems based on nanostructured porous silicon loaded with the anti-tumoral drug emodin adsorbed on silver nanoparticles

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