Functional Visual Acuity of Early Presbyopia

Katada, Yusaku; Negishi, Kazuno; Watanabe, K.; Shigeno, Yuta; Saiki, Megumi; Torii, Hidemasa; Kaido, Minako

doi:10.1371/journal.pone.0151094

Cited by 23 publications

(34 citation statements)

References 39 publications

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“…Subsequent studies showed that the FVA measurement is also applicable for the analysis of visual function accompanying refractive surgery, 20,[56][57][58] contact lens wearing, 59,60 cataract and cataract-related disease, 61,62 retinal disease, 63,64 glaucoma, 65 amblyopia, 66 presbyopia, 67 and vehicle driving. 68,69 FVA reflects not only visual function related to tear dynamics, but also visual function related to quick recognition of the target, according to the measurement condition requiring a judgment time within the limited set time.…”

Section: Future Directionsmentioning

confidence: 99%

Functional Visual Acuity

Kaido

2018

Invest. Ophthalmol. Vis. Sci.

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Dry eye (DE) causes irregularity of the ocular surface and reduces the quality of vision. An intact, regular tear film is essential for high-quality retinal images; however, visual tasks requiring sustained gazing can disrupt the tear film, eventually degrading visual function. A functional visual acuity (FVA) measurement system has been uniquely developed in Japan to evaluate visual function related to tear stability in patients with DE. FVA has been shown to correlate with optical quality. The system measures the change in visual acuity (VA) over time automatically in aqueous-deficient DE and short tear breakup tear film DE characterized by decreased tear stability and minimal epithelial damage. It is also useful to detect minimal visual deterioration correlated with minimal ocular surface abnormality and vision-related quality of life otherwise undetectable by conventional VA testing, to assess and quantify vision-related symptomatology, and to determine the efficacy of treatments for DE disease. Recently, its use has been expanded, such as for the analysis of visual function accompanying refractive surgery, contact lens, cataract and cataract-related disease, retinal disease, glaucoma, amblyopia, presbyopia, and vehicle driving. Its use has revealed that FVA reflects not only visual function related to tear dynamics, but also visual function related to quick recognition of the target. This simple, noninvasive, and sensitive FVA measurement system may be expected to be used worldwide.

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Section: Future Directionsmentioning

confidence: 99%

Functional Visual Acuity

Kaido

2018

Invest. Ophthalmol. Vis. Sci.

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“…The FVA measurement has been reported to detect early presbyopia more sensitively than the usual VA measurement 17 . The AS-28 (Kowa Co. Ltd., Aichi, Japan) was used to measure the FVA.…”

Section: Methodsmentioning

confidence: 99%

Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy

Tsuneyoshi

Higuchi

Negishi

et al. 2017

Sci Rep

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Various methods can correct presbyopia, but all require devices or surgeries. Recently, supplements or warming devices to relieve presbyopic symptoms have been developed, but no eye drops have been developed. We screened certain compounds possibly related to lens degeneration and identified pirenoxine, which has been used for cataracts, as a possible new pharmacologic treatment for presbyopia. We first researched the anti-presbyopic activity of pirenoxine in rats. The lens elasticity significantly (p = 0.028) increased with exposure to tobacco smoke for 12 days, and pirenoxine eye drops significantly (p < 0.001) suppressed lens hardening, which causes presbyopia in humans. In a parallel randomized controlled clinical study of the subjects in their fifth decade of life, the objective accommodative amplitude (AA) decreased significantly (p < 0.01) by 0.16 diopter (D) in the control group, and there was no detectable change in the treatment group after a 6-month treatment period, suggesting that pirenoxine eye drops might prevent progression of presbyopia. Subjects in their sixth decade of life, in whom the AA was already nearly 0 D, did not show similar results. Pirenoxine eye drops might be a new and the first pharmacologic treatment for preventing progression of presbyopia.

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“…It is speculated that both KVA and FVA are important for major integrated visual function working with continuous fixation. FVA may deteriorate in cataract, posterior capsule opacification, DE and age-related macular degeneration 23–28. These are treatable eye diseases and adequate ophthalmological treatments are recommended for drivers suffering these diseases to achieve the best possible visual performance.…”

Section: Discussionmentioning

confidence: 99%

Kinetic visual acuity is correlated with functional visual acuity at higher speeds

et al. 2019

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ObjectiveTo measure the kinetic visual acuity (KVA) which is the ability to identify approaching objects and the functional visual acuity (FVA) which is continuous VA during 1 min under binocular and monocular condition (non-dominant eye shielding) for healthy subjects, and related ocular parameters to explore their correlation and implication in aspect of integrated visual function.MethodsThe mean age of the 28 participants was 38.6±8.9 years (range, 23–57 years; 6 women). A KVA metre (AS-4Fα) and FVA metre (AS-28) were used to measure KVA and FVA, respectively. Multiple regression analysis was conducted to explore correlations among the measured visual function and related parameters, including age, binocularity, best-corrected visual acuity, refraction and tear break-up time.ResultsThe results of binocular KVA were better than monocular KVA at all speeds. A strong correlation was found between monocular and binocular KVA. The results of binocular FVA were better than monocular FVA (p<0.001) and there was a correlation between monocular and binocular FVA (R=0.638, p<0.001), as well as the maintenance rate for FVA (R=0.228, p=0.003). A linear mixed-effects model revealed that binocularity for KVA prediction was significant at all speeds and FVA was also significant at 60 km/h (p<0.05).ConclusionThe current results suggest that both binocularity and FVA may contribute to KVA.Trial registration numberUMIN00032385

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Functional Visual Acuity of Early Presbyopia

Cited by 23 publications

References 39 publications

Functional Visual Acuity

Functional Visual Acuity

Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy

Kinetic visual acuity is correlated with functional visual acuity at higher speeds

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