Functional teratogens of the rat kidney I. Colchicine, dinoseb, and methyl salicylate

Daston, George P.; Rehnberg, Blair F.; Carver, Brenda; Rogers, Ellen H.; Kavlock, Robert J.

doi:10.1016/0272-0590(88)90104-2

Cited by 30 publications

(23 citation statements)

References 27 publications

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“…administration of dinoseb on GDs 9-11; however, no grossly observable hydronephrosis was evident in pups at 1 or 2 weeks of age. Renal alteration observed in offspring of mice given dinoseb seems to be a transient dilatation of the renal pelvis, which is also suggested by studies in rats (Daston et al, 1988;McCormack et al, 1980), as described in 4.3. On the other hand, i.p.…”

Section: Intraperitoneal Studies In Micesupporting

confidence: 53%

“…Postnatal observation on PND 30 revealed that there was a body weight reduction and an increase in relative kidney weight at 10.5 mg/kg bw/day. On PND 6, there were a deficit in urinary concentrating ability in pups of dams given dinoseb on GDs 9-11 at 10.5 mg/kg bw/day (Daston et al, 1988). As described above, dinoseb produced suggestive renal damage in rat offspring following maternal administration.…”

Section: Intraperitoneal Studies In Ratsmentioning

confidence: 69%

“…Several studies including our previous study did not demonstrate the teratogenicity of dinoseb in rats (Daston et al, 1988;Matsumoto et al, 2008a;McCormack et al, 1980), but we considered that the teratogenic potential of dinoseb in rats was unclear because of the influence of variable factors. Because detailed test conditions were not described in the studies of Giavini et al (Giavini et al, 1989;Giavini et al, 1986), adequate experimental conditions for the production of fetal malformations by the administration of dinoseb to pregnant rats remained unknown.…”

Section: Further Clarification Of Teratogenicity In Ratsmentioning

confidence: 95%

“…Developmental toxicity of dinoseb administered in diet in rats a: only secondary literature or abstract is available b: the details are described in 4.4 GDs: gestation days McCormack et al (1980). In the study of Daston et al (1988) a deficit in urinary concentrating ability observed during postnatal development also disappeared after functional maturation (PND 30). Prenatal incidence of dilated renal pelvis was not dosedependent.…”

Section: Intraperitoneal Studies In Ratsmentioning

confidence: 99%

“…Dose Exposure time Developmental effect (Reference) _________________________________________________________________________________ SD rat 8.0 mg/kg GDs 9-11 ↓Fetal body weight, dilated renal pelvis and ureters in fetuses Pathological changes in liver and kidney in fetuses and neonates 9.0 mg/kg ↓Fetal crown-rump length, ↓ neonatal body weight (McCormack et al, 1980) SD rat 7.5 mg/kg GDs 9-11, 10-12 ↓Fetal body weight 10.5 mg/kg Functional defect of kidney (PND 6), ↓body weight in pups (PND 30), ↑relative weight of kidney (PND 30) (Daston et al, 1988) _________________________________________________________________________________ Table 3.3. Developmental toxicity of dinoseb administered by intraperitoneally in rats GDs: gestation days PND: postnatal day…”

Section: Speciesmentioning

confidence: 99%

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Developmental Toxicity of Nitrophenolic Herbicide Dinoseb, 2-Sec-Butyl-4,6-Dinitrophenol

Matsumoto¹,

Hirose²,

Ema³

2011

Herbicides and Environment

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Section: Intraperitoneal Studies In Micesupporting

confidence: 53%

Section: Intraperitoneal Studies In Ratsmentioning

confidence: 69%

Section: Further Clarification Of Teratogenicity In Ratsmentioning

confidence: 95%

Section: Intraperitoneal Studies In Ratsmentioning

confidence: 99%

Section: Speciesmentioning

confidence: 99%

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Developmental Toxicity of Nitrophenolic Herbicide Dinoseb, 2-Sec-Butyl-4,6-Dinitrophenol

Matsumoto¹,

Hirose²,

Ema³

2011

Herbicides and Environment

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Esters of Monocarboxylic Acids

Ziegler‐Skylakakis

2023

Patty's Toxicology

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This chapter deals with esters of monocarboxylic acids as well as with monoalcohols, di‐, tri‐, or polyalcohols, such as glycerol esters, resorcinol esters, and gallates. The esters of aromatic monocarboxylic acids are benzoates, salicylates, parabens, cinnamates, p ‐aminobenzoates, and o ‐aminobenzoates. The chemical structures and the physicochemical properties of these chemicals vary considerably. Accordingly, they are widely used in different industrial settings and consumer products. Some of these compounds occur naturally. They exhibit in general a low toxicity.

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Reproductive and Developmental Toxicology

Kimmel¹,

Buelke-Sam²

2001

Patty's Toxicology

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This chapter provides a brief overview of normal reproduction and development, as well as examples of how toxic agents may impact these processes. It summarizes the types of studies conducted and data collected as part of routine toxicity testing. Assumptions that must be made in the risk assessment process and an evaluation of data from both animal and human studies used in this process are discussed. The integration of hazard data (both animal and human) and dose–response information is described, and exposure estimates in the final characterization of risk are summarized. Advances have been made in our understanding of reproductive and developmental toxicity, particularly as the integration of molecular biology and toxicology has grown. However, there are still many gaps in our knowledge of both normal and abnormal reproductive and developmental processes. Further research will continue to fill these gaps and enhance our ability to identify more specific susceptible events in these processes and ultimately reduce adverse reproductive and developmental outcomes due to chemical exposures. The views expressed in this chapter are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency. Mention of trade names of commercial products does not constitute endorsement or recommendation for use.

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Functional teratogens of the rat kidney I. Colchicine, dinoseb, and methyl salicylate

Cited by 30 publications

References 27 publications

Developmental Toxicity of Nitrophenolic Herbicide Dinoseb, 2-Sec-Butyl-4,6-Dinitrophenol

Developmental Toxicity of Nitrophenolic Herbicide Dinoseb, 2-Sec-Butyl-4,6-Dinitrophenol

Esters of Monocarboxylic Acids

Reproductive and Developmental Toxicology

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