Developmental Toxicity of Nitrophenolic Herbicide Dinoseb, 2-Sec-Butyl-4,6-Dinitrophenol

Matsumoto, Mariko; Hirose, Akihiko; Ema, Makoto

doi:10.5772/13302

Cited by 2 publications

(1 citation statement)

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“…The high-degree biological components in both exposome-proteome and exposome-metabolome analyses were mainly fungi, yet few had known human health effects. However, we identified major high-degree annotated chemicals that are known human stressors; for instance, the herbicide dinoseb exposure causes various developmental toxicities and loss of thyroid and body weight 40 , and brominated flame retardants like tetrabromobisphenol A diallyl ether are known neurotoxicants 41 . In addition to the endogenous metabolites, we were able to annotate 60 toxins and carcinogens in the individual’s blood based on the exposome related databases ( Figure 1c ).…”

Section: Discussionmentioning

confidence: 99%

Precision environmental health monitoring by longitudinal exposome and multi-omics profiling

Gao

Shen

Zhang

et al. 2021

Preprint

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Conventional environmental health studies primarily focus on limited environmental stressors at the population level, which lacks the power of dissecting the complexity and heterogeneity of individualized environmental exposures. Here we integrated deep-profiled longitudinal personal exposome and internal multi-omics to systematically investigate how the exposome shapes an individual's phenome. We annotated thousands of chemical and biological components in the personal exposome cloud and found thousands of internal biomolecules were significantly correlated with the external exposome, which was further cross validated using corresponding clinical data. In particular, our results showed that agrochemicals and fungi predominated in the highly diverse and dynamic personal exposome, and the biomolecules and pathways related to the individual's immune system, kidneys, and liver were highly correlated with the personal external exposome. Overall, our findings demonstrate dynamic interactions between the personal exposome and internal multi-omics and provide insights into the impact of the environmental exposome on precision health.

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Section: Discussionmentioning

confidence: 99%