Functional supramolecular bioactivated electrospun mesh improves tissue ingrowth in experimental abdominal wall reconstruction in rats

Cunha, Marina Gabriela Monteiro Carvalho Mori da; Arts, Boris; Hympánová, Lucie; Rynkevic, Rita; Mackova, Katerina; Bosman, Anton W.; Dankers, Patricia Y. W.; Deprest, Jan

doi:10.1016/j.actbio.2020.01.041

Cited by 34 publications

(29 citation statements)

References 30 publications

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Section: Resultsmentioning

confidence: 99%

“…This enables both the introduction of functional motifs and bioactive components and allows for tunable mechanical and degradative properties. [ 38 ] The feasibility of these supramolecular graft materials is shown by several in vivo studies for various applications, ranging from meshes for abdominal wall reconstruction [ 39 ] to vascular grafts [ 40,41 ] and heart valves. [ 42–44 ] By immobilizing heparin using a supramolecular incorporated heparin‐binding peptide as described in this study, the protein binding properties of heparin can be modularly exploited to bind additional growth factors or cytokines.…”

Section: Discussionmentioning

confidence: 99%

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Distinct Effects of Heparin and Interleukin‐4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats

Bonito

Koch

Krebber

et al. 2021

Adv Healthcare Materials

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Two of the greatest challenges for successful application of small‐diameter in situ tissue‐engineered vascular grafts are 1) preventing thrombus formation and 2) harnessing the inflammatory response to the graft to guide functional tissue regeneration. This study evaluates the in vivo performance of electrospun resorbable elastomeric vascular grafts, dual‐functionalized with anti‐thrombogenic heparin (hep) and anti‐inflammatory interleukin 4 (IL‐4) using a supramolecular approach. The regenerative capacity of IL‐4/hep, hep‐only, and bare grafts is investigated as interposition graft in the rat abdominal aorta, with follow‐up at key timepoints in the healing cascade (1, 3, 7 days, and 3 months). Routine analyses are augmented with Raman microspectroscopy, in order to acquire the local molecular fingerprints of the resorbing scaffold and developing tissue. Thrombosis is found not to be a confounding factor in any of the groups. Hep‐only‐functionalized grafts resulted in adverse tissue remodeling, with cases of local intimal hyperplasia. This is negated with the addition of IL‐4, which promoted M2 macrophage polarization and more mature neotissue formation. This study shows that with bioactive functionalization, the early inflammatory response can be modulated and affect the composition of neotissue. Nevertheless, variability between graft outcomes is observed within each group, warranting further evaluation in light of clinical translation.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Distinct Effects of Heparin and Interleukin‐4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats

Bonito

Koch

Krebber

et al. 2021

Adv Healthcare Materials

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“…The fabrication of DEX/SS and Gold@DEX/SS nanomaterials due to its abundant availability, comfort interfacial properties, high heat conductivity, and hydrophobicity, it was favored over other types of cotton [44][45][46][47]. The cotton fabric was dehydrated at 55 °C after being soaked in DEX/ SS and Gold@DEX/SS solutions.…”

Section: Fabrication Of Dex/ss and Gold@dex/ssmentioning

confidence: 99%

Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing

Chen

Bian

2021

J Clust Sci

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Gold-loaded nanoparticles are versatile nanomaterials that may be used in wound healing properties. The current study describes a wound dressing formulation focused on Gold-loaded Dextran/Silk Sericin nanoparticles. The Gold-loaded Dextran/Silk Sericin membranes were fabricated using Gold solutions inside the Dextran/Silk Sericin medium. The influence of various experimental conditions on Dextran/Silk Sericin nanoparticle formations were examined. The sizes of Dextran/Silk Sericin and Gold@Dextran/Silk Sericin nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of Dextran/Silk Sericin and Gold-loaded Dextran/Silk Sericin nanoparticles was evaluated against the microorganisms gram-positive and negative. Furthermore, we observed the in vivo wound healing of wounds in skin using a mice model over a 16 days period. In this difference to the wounds of untreated mouse, quick healing was observed in the Gold-loaded Dextran/Silk Sericin nanoparticles-treated wounds with fewer injury. These results specify that Gold-loaded Dextran/Silk Sericin nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound damages, which was proven using an animal model.

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“…Postoperative adhesion (POA) is a comprehensive in ection of various abnormal tissue hyperplasias, characterized by proliferated brous tissues sticking to the nearby normal organs [9][10][11]. The adhesion bands can take diversi ed phenotypes ranging from a thin layer of brous lms between the adjacent tissues to a mixture of brous tissues, blood vessels, and nerves [12][13][14]. Depending on distinct positions and levels of the adhesion, POA may be accompanied with acute complications or be "silent" for several years.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

et al. 2021

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The developments of lidocaine chloride loaded nanoparticles are encouraging biomaterials, which could be used for wound healing applications for abdominal pain management. The current work presents the composition of wound dressings based on lidocaine chloride (LCH) (anesthetic drug)-loaded Polymyxin (PMN)/Glycol (GLY). The LCH nanocomposite (LCH@PMN/GLY) were fabricated by the LCH oxide solutions within the PMN/GLY matrix. The in uences of different experimental limitations on PMN/GLY nanoparticles formations were examined. The PMN/GLY and LCH@PMN/GLY nanoparticle sizes were evaluated by high resolution-scanning electron microscopy (HR-SEM). Additionally, the antibacterial e cacy of PMN/GLY and LCH@PMN/GLY was developed for gram-positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 20 days. In contrast to the untreated wounds, rapid healing was perceived in the LCH@PMN/GLY-treated wound with less damage. These ndings indicate that LCH@PMN/GLY-based bandaging materials could be a potential innovative biomaterial for tissue repair and implantation and nursing care for wound healing applications for abdominal pain incision in intensive care unit (ICU) management in an animal model.

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Functional supramolecular bioactivated electrospun mesh improves tissue ingrowth in experimental abdominal wall reconstruction in rats

Cited by 34 publications

References 30 publications

Distinct Effects of Heparin and Interleukin‐4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats

Distinct Effects of Heparin and Interleukin‐4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats

Synergic Fabrication of Gold Nanoparticles Embedded Dextran/ Silk Sericin Nanomaterials for the Treatment and Care of Wound Healing

In Vivo Observation of Lidocaine-Encapsulated Polymyxin/Glycol Nanoparticles Wound Dressing for the Treatment and Care of Abdominal Pain Incision in Intensive Care Unit

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