Functional status of patients after stroke

Tomasevic-Todorovic, Snezana; Kopčanski, Sanja; Mikov, Aleksandra; Boskovic, Ksenija; Popovic-Petrovic, Svetlana; Savić, Mirjana

doi:10.2298/mpns1506181t

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Concerning motor disabilities, contralateral upper limb paresis is also a consequence of ischemic stroke in humans 7 . This outcome is well characterized by asymmetry of front paws in ischemic animals 40, 59 .…”

Section: Discussionmentioning

confidence: 99%

“…Ischemic stroke most common symptoms are motor and cognitive impairment 3–5 . Currently it is known that ischemic stroke represents ~85% of stroke cases 6 , in which approximately 80% cause contralateral upper limb paresis 7 and sensory function impairment 8 . In addition, clinical observations show that 20–50% of patients experience memory disorders 9, 10 .…”

Section: Introductionmentioning

confidence: 99%

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Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Rohden

et al. 2020

Preprint

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Ischemic stroke is a prominent cause of death and disability, demanding innovative therapeutic strategies. Accordingly, extracellular vesicles (EVs) released from mesenchymal stem cells are promising tools for stroke treatment. In this study, we evaluated the potential neuroprotective properties of EVs released from human adipose tissue stem cells (hAT-MSC), which were obtained from a healthy individual submitted to liposuction. A single intranasal EVs administration was performed 24 h after the ischemic stroke in rats. The EVs brain penetration and the tropism to brain zone of ischemia was observed 18 h after administration. Thus, we measured EVs neuroprotection against the ischemic stroke-induced impairment on long-term motor and behavioral performance. Indeed, one single intranasal EVs administration reversed the stroke damages on: i) front paws symmetry; ii) working memory, short- and long-term memory; iii) anxiety-like behavior. These findings highlight hAT-MSC-derived EVs as a promising therapeutic strategy in stroke.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Rohden

et al. 2020

Preprint

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“…Hampir seluruh klien stroke yang menjadi responden memiliki salah satu dari ketiga masalah tersebut. 8 Hasil metanalisis dari Wist, S., Clivaz, J., & Sattelmayer, M. (2016) menemukan bahwa kelemahan ekstremitas merupakan komplikasi yang paling umum terjadi setelah serangan stroke. Sekitar 70% penderita stroke mengalami kelemahan baik pada ekstremitas atas maupun bawah.…”

Section: Pendahuluanunclassified

Penerapan Program Pemberdayaan Keluarga Sebagai Upaya Meningkatkan Status Fungsional Klien dan Kesiapan Keluarga Merawat Klien Stroke

Arista¹,

Nurachmah²,

Herawati³

2020

JIIKI

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Pendahuluan: Stroke merupakan kondisi hilangnya fungsi otak karena gangguan aliran darah otak terjadi lebih dari 24 jam. Stroke berdampak fisik maupun mental sehingga klien stroke bergantung kepada keluarga serta membutuhkan perawatan dan pemulihan jangka panjang. Tujuan: Tujuan penelitian untuk mengetahui pengaruh program pemberdayaan keluarga terhadap status fungsional klien dan kesiapan keluarga merawat klien stroke. Metode: Desain penelitian quasi experiment dengan pendekatan control group pretest posttest design pada 25 responden meliputi 12 orang kelompok kontrol dan 13 orang kelompok intervensi. Hasil: Hasil penelitian menunjukkan tidak terdapat perbedaan yang bermakna status fungsional klien antara kelompok kontol dan intervensi setelah program pemberdayaan. Namun, terdapat perbedaan yang bermakna kesiapan keluarga merawat klien stroke antara kelompok kontrol dan intervensi (p = 0,004 pada α = 0,05). Kesimpulan: Oleh karena itu, pemberian program pemberdayaan keluarga direkomendasikan sebagai intervensi keperawatan untuk mempersiapkan keluarga melaksanakan perawatan terutama ketika klien stroke pulang ke rumah.

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“…Stroke is a major cause of death and permanent disability worldwide, affecting health and nancial capabilities [1,2]. Ischemic stroke represents ~ 85% of stroke cases [3][4][5][6], in which approximately 80% cause contralateral upper limb paresis [7] and sensory function impairment [8]. In addition, clinical observations have shown that 20-50% of patients experience memory disorders [9,10].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotection from Stem Cell-Derived Human Adipose Extracellular Vesicles Intranasally Administered 24 Hours After Stroke in Rats. 

Rohden¹,

Teixeira²,

Bernardi³

et al. 2021

Preprint

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Ischemic stroke is a major cause of death and disability, demanding innovative and accessible therapeutic strategies. Approaches presenting an optimal period for therapeutic intervention and new treatment administration routes are promising tools for stroke treatment. We evaluated the potential neuroprotective properties of nasally administered human adipose tissue stem cells (hAT-MSCs)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. A single intranasal EV (200 µg/kg) was administered 24 h after a focal permanent ischemic stroke in rats. A higher tropism of EVs was observed in the peri-infarct zone surrounding the infarct core. In the same brain region, there was a significant decrease in the infarct volume, improvement of the blood-brain barrier, and re-stabilization of vascularization. In addition, EVs recovered the impairment of long-term motor and behavioral performance induced by an ischemic stroke. Surprisingly, one single intranasal EVs administration reestablished: i) front paws symmetry, ii) short- and long-term memory, and iii) anxiety-like behavior. In line with the findings, our work highlights hAT-MSC-derived EVs as a promising therapeutic strategy for stroke.

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Functional status of patients after stroke

Abstract: The obtained results showed that the rehabilitation treatment resulted in better functional and motor recovery in the patients who had had ischemic stroke.

Cited by 8 publications

References 10 publications

Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Penerapan Program Pemberdayaan Keluarga Sebagai Upaya Meningkatkan Status Fungsional Klien dan Kesiapan Keluarga Merawat Klien Stroke

Neuroprotection from Stem Cell-Derived Human Adipose Extracellular Vesicles Intranasally Administered 24 Hours After Stroke in Rats.

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Functional status of patients after stroke

Abstract: The obtained results showed that the rehabilitation treatment resulted in better functional and motor recovery in the patients who had had ischemic stroke.

Cited by 8 publications

References 10 publications

Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Penerapan Program Pemberdayaan Keluarga Sebagai Upaya Meningkatkan Status Fungsional Klien dan Kesiapan Keluarga Merawat Klien Stroke

Neuroprotection from Stem Cell-Derived Human Adipose Extracellular Vesicles Intranasally Administered 24 Hours After Stroke in Rats.&nbsp;

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Neuroprotection from Stem Cell-Derived Human Adipose Extracellular Vesicles Intranasally Administered 24 Hours After Stroke in Rats.