Functional specification in the <i>Drosophila</i> endoderm

Nakagoshi, Hideki

doi:10.1111/j.1440-169x.2005.00811.x

Cited by 44 publications

(45 citation statements)

References 63 publications

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“…In this regard, the metabolic state and gene expression in these cells directed or regulated by nutrients are coordinated toward this fate for cells, which imprints onto the subsequent organogenesis. During organogenesis, the endodermal cells in gastrula indeed differentiate and give rise to the epithelial lining of the digestive tract, associated glands and respiratory system in vertebrates [14], as well as in Drosophila [15]. In this respect, the regulation of both cell state and gene classes in endoderm with proposed nutrient gradient during gastrulation fits well with the phenotypic outcome of development, supporting the rationality of the theory.…”

Section: Phenotypic Fates Of Three Germ Layers In Gastrulasupporting

confidence: 58%

“…The endoderm is destined to differentiate into the epithelial lining of digestive tract, associated glands and respiratory system in both vertebrates [14] and Drosophila [15]. The ectoderm is destined to differentiate into the neural progenitors and epidermal progenitors in vertebrates [16], and to neural cells [17] and epidermal cuticle in Drosophila [18].…”

Section: Nutrient Preserving the Trilaminar Fates In Gastrula Versus mentioning

confidence: 99%

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Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

Cai¹

2016

OALib

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In this article, it is newly suggested the regulation from nutrient gradient on both cell metabolic state and expressional gene classes as the conserved mechanism differentiating the cell fates for formation of the three germ layers of gastrula in animals. As a new theory, it is supported by the totipotency and pluripotency of early embryonic cells and cultured stem cells to be regulated by nutrients, as well as by the universal formation of nutrient gradient during gastrulation in various animals. Besides, it is also supported by the subsequent phenotypic fates of three germ layers of gastrula, with the endoderm manifesting expression of gene classes in nutritious condition and giving rise to the epithelium of digestive and respiratory system; the ectoderm manifesting expression of gene classes with nutrient dependence and environmental effect, and giving rise to the nervous and epithelial tissues; the mesoderm lying between them and giving rise to the muscle and adipose. Likewise, it is directly supported by the different nutrient effects onto such trilaminar differentiation in various cultured stem cells. Finally, it is in further supported by the evolutionary effects of nutrients in preserving the trilaminar fates in gastrula versus relative permitting the variations in anteroposterior determination. Conclusively, it is identified the nutrient gradient as an important mechanism to partially differentiate the cell fates for embryonic gastrulation.

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Section: Phenotypic Fates Of Three Germ Layers In Gastrulasupporting

confidence: 58%

Section: Nutrient Preserving the Trilaminar Fates In Gastrula Versus mentioning

confidence: 99%

Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

Cai¹

2016

OALib

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“…The role of the D. melanogaster midgut in food digestion is well accepted (50) and contains at least 13 different distinct regions of gene expression, likely to be composed of multiple cell types (51). The anterior portion of the midgut (m1-4) is suggested to play some role in immunity (52,53), although the functions of many midgut regions are not well established (54,55). Using in situ hybridization, we detected expression of different P450s in a number of specific but different midgut regions in third instar larvae (Fig.…”

mentioning

confidence: 96%

Characterization of Drosophila melanogaster cytochrome P450 genes

Chung

Sztal

Pasricha

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

256

235

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Cytochrome P450s form a large and diverse family of hemecontaining proteins capable of carrying out many different enzymatic reactions. In both mammals and plants, some P450s are known to carry out reactions essential for processes such as hormone synthesis, while other P450s are involved in the detoxification of environmental compounds. In general, functions of insect P450s are less well understood. We characterized Drosophila melanogaster P450 expression patterns in embryos and 2 stages of third instar larvae. We identified numerous P450s expressed in the fat body, Malpighian (renal) tubules, and in distinct regions of the midgut, consistent with hypothesized roles in detoxification processes, and other P450s expressed in organs such as the gonads, corpora allata, oenocytes, hindgut, and brain. Combining expression pattern data with an RNA interference lethality screen of individual P450s, we identify candidate P450s essential for developmental processes and distinguish them from P450s with potential functions in detoxification.detoxification genes ͉ in situ hybridization ͉ insecticide resistance ͉ multigene family ͉ RNAi

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“…In fact, three distinct gastrointestinal tissues supersede one another during development: the larval gut (arising from the embryonic gut), the transient pupal gut, and the adult gut (see References 109,124,176,178 for details). After metamorphosis, both the larval and pupal midgut degenerate to form meconium, which is expelled soon after eclosion.…”

Section: The Drosophila Gut: a Plastic Organmentioning

confidence: 99%

The Digestive Tract of Drosophila melanogaster

2013

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The digestive tract plays a central role in the digestion and absorption of nutrients. Far from being a passive tube, it provides the first line of defense against pathogens and maintains energy homeostasis by exchanging neuronal and endocrine signals with other organs. Historically neglected, the gut of the fruit fly Drosophila melanogaster has recently come to the forefront of Drosophila research. Areas as diverse as stem cell biology, neurobiology, metabolism, and immunity are benefitting from the ability to study the genetics of development, growth regulation, and physiology in the same organ. In this review, we summarize our knowledge of the Drosophila digestive tract, with an emphasis on the adult midgut and its functional underpinnings. 377

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Functional specification in the Drosophila endoderm

Cited by 44 publications

References 63 publications

Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory

Characterization of Drosophila melanogaster cytochrome P450 genes

The Digestive Tract of Drosophila melanogaster

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