Regulation of Both Cell State and Gene Expression with Nutrient Gradient as Conserved Mechanism Differentiating the Cell Fates for Embryonic Gastrulation: A Theory
Abstract:In this article, it is newly suggested the regulation from nutrient gradient on both cell metabolic state and expressional gene classes as the conserved mechanism differentiating the cell fates for formation of the three germ layers of gastrula in animals. As a new theory, it is supported by the totipotency and pluripotency of early embryonic cells and cultured stem cells to be regulated by nutrients, as well as by the universal formation of nutrient gradient during gastrulation in various animals. Besides, it… Show more
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