Functional sodium magnetic resonance imaging of the intact rat kidney

Maril, Nimrod; Margalit, Raanan; Mispelter, Joël; Degani, Hadassa

doi:10.1111/j.1523-1755.2004.00475.x

Cited by 51 publications

(87 citation statements)

References 53 publications

(72 reference statements)

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“…In addition, Wolff et al measured the sodium signal intensity gradient and the relaxation times in the exposed rabbit kidney at different hydration states (19). Recently we used sodium MRI to investigate the tissue sodium concentration in the intact rat kidney (22). In that study we showed that the renal TSC increases in a linear manner from 60 mM in the cortex to 360 mM in the papilla tip at a rate of 31 mM/mm.…”

Section: Introductionmentioning

confidence: 89%

Sodium magnetic resonance imaging of diuresis: Spatial and kinetic response

Maril

Margalit

Mispelter

et al. 2005

Magnetic Resonance in Med

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Renal function is highly correlated with the sodium concentration gradient along the corticomedullary axis. The application of 3D high-resolution sodium magnetic resonance imaging (MRI) provided a means to quantify in vivo the spatial and temporal changes in renal tissue sodium concentration under normal and diuretic conditions. A detailed, pixel-by-pixel analysis of the intact rat kidney sodium MR images yielded a quantitative measure of the corticomedullary sodium gradient before and at early and later times after the administration of two distinct diuretic agents, furosemide and mannitol. Furosemide, a loop diuretic, induced a fivefold reduction in the cortical-outer medullary sodium gradient, whereas mannitol, an osmotic diuretic, did not affect this gradient. Both diuretics induced a 50% decrease in the sodium concentration of the inner medulla; however, mannitol exerted its effect twice as fast as furosemide with a 2.5-min exponential decay constant. These specific changes were attributed to the different mechanism of action and site of activity of each diuretic agent. Thus, high-resolution 23 Na MRI offers a unique, noninvasive tool for functional imaging of the kidney physiology. Magn Reson Med 53:545-552, 2005.

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Section: Introductionmentioning

confidence: 89%

Sodium magnetic resonance imaging of diuresis: Spatial and kinetic response

Maril

Margalit

Mispelter

et al. 2005

Magnetic Resonance in Med

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“…However, there are several other techniques that have been demonstrated as potential fMRI methods with specific applications to the kidney. These include diffusion measurements in the kidney (79,94,122,135), pH measurements (119), and, more recently, sodium MRI (84). While diffusion measurements certainly provide opportunities for tissue characterization, it is not quite clear what the measured values represent in terms of the functional status of the kidney.…”

Section: Other Fmri Techniques and Recent Developmentsmentioning

confidence: 99%

“…While diffusion measurements certainly provide opportunities for tissue characterization, it is not quite clear what the measured values represent in terms of the functional status of the kidney. A more recent development is the feasibility of performing sodium (Na) MRI (84) to follow the urinary concentrating process directly. MRI has the ability to directly measure the tissue sodium concentration noninvasively.…”

Section: Other Fmri Techniques and Recent Developmentsmentioning

confidence: 99%

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Prasad

2006

American Journal of Physiology-Renal Physiology

106

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“…With increasing static magnetic field strengths and stronger, faster and more accurately controllable gradient and acquisition hardware, 23 Na Magnetic Resonance Imaging ( 23 Na-MRI) has become a promising technique to investigate diseased tissue states non-invasively in pre-clinical models of disease [1][2][3][4]. The potential diagnostic benefits of 23 Na-MR imaging have recently been demonstrated for common pathological conditions such as tumor [5,6], stroke [7][8][9], Alzheimer disease [10], paramyotonia [11], arthritis [12], multiple sclerosis [13] and functional renal imaging [14] in humans.…”

Section: Introductionmentioning

confidence: 99%

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

Wetterling

Högler

Molkenthin

et al. 2012

Journal of Magnetic Resonance

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The design and construction of a two-port surface transceiver resonator for both 1 H-and 23 Na-MRI in the rodent brain at 7T is described. Double-tuned resonators are required for accurately co-registering multi-nuclei data sets, especially when the time courses of 1 H and 23 Na signals are of interest as, for instance, when investigating the pathological progression of ischaemic stroke tissue in vivo. In the current study, a single-element two-port surface resonator was developed wherein both frequency components were measured with the same detector element but with each frequency signal routed along different output channels.This was achieved by using the null spot technique, allowing for optimal variable tuning and matching of each channel in situ within the MRI scanner. The 23 Na signal to noise ratio, measured in the ventricles of the rat brain, was increased by a factor of four compared to recent state-of-the-art rat brain studies reported in the literature. The resonator's performance was demonstrated in an in vivo rodent stroke model, where regional variations in 1 H apparent diffusion coefficient maps and the 23 Na signal were recorded in an interleaved fashion as a function of time in the acute phase of the stroke without having to exchange, re-adjust, or re-connect resonators between scans. Using the practical construction steps described in this paper, this coil design.

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Functional sodium magnetic resonance imaging of the intact rat kidney

Abstract: Quantitative assessment of the renal corticomedullary sodium gradient by high resolution sodium MRI may help verify new aspects of the kidney concentrating mechanism and serve as a non-invasive diagnostic method of renal function.

Cited by 51 publications

References 53 publications

Sodium magnetic resonance imaging of diuresis: Spatial and kinetic response

Sodium magnetic resonance imaging of diuresis: Spatial and kinetic response

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI

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