Functional significance of bioactive peptides derived from soybean

Singh, Brij Pal; Vij, Shilpa; Hati, Subrota

doi:10.1016/j.peptides.2014.01.022

Cited by 434 publications

(281 citation statements)

References 109 publications

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“…Proteins and peptides obtained from plant and animal sources (Table 1) have been found to improve lymphocyte proliferation, natural killer (NK), cell activity, antibody synthesis and cytokine regulation (Singh et al, 2014). Recently, milk bioactive peptides released by selected Lactobacillus helveticus strains (Elfahri et al, 2014) and the frog skin host-defense peptides (Mechkarska et al, 2014) were shown to induce stimulatory influence on the production of cytokines with pro-and antiinflammatory effects.…”

Section: Immunomodulatory Effectmentioning

confidence: 99%

“…Therefore, special attention has been given to ACE inhibitory effects of nutraceuticals from bio-resources. Bioactive peptides from natural resources have been found to have a high level of ACE-inhibitory and antihypertensive effects (Je et al, 2005a, b, c;Jung et al, 2006;Nii et al, 2008;Lee et al, 2010;Yamamoto, 2010;Adje et al, 2011;Norris and FitzGerald, 2013;Singh et al, 2014;Mohanty et al, 2015;Capriotti et al, 2015;Esteve et al, 2015;El Hatmi et al, 2016). These peptides are very valuable because they have variety of functions and they are easily absorbed in the body and therefore, they can potentially be considered a great alternative for the synthetic antihypertensive drugs (Lee et al, 2010).…”

Section: Ace Inhibitory and Antihypertensive Effectmentioning

confidence: 99%

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Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

120

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Production of peptides with various effects from proteins of different sources continues to receive academic attention. Researchers of different disciplines are putting increasing efforts to produce bioactive and functional peptides from different sources such as plants, animals, and food industry by-products. The aim of this review is to introduce production methods of hydrolysates and peptides and provide a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems. Moreover, functional and antioxidant properties of hydrolysates and isolated peptides are reviewed. Finally, industrial and commercial applications of bioactive peptides including their use in nutrition and production of pharmaceuticals and nutraceuticals are discussed.

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Section: Immunomodulatory Effectmentioning

confidence: 99%

Section: Ace Inhibitory and Antihypertensive Effectmentioning

confidence: 99%

Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

120

View full text Add to dashboard Cite

show abstract

“…As we know, the enzyme-treated proteins have much better utilization and rich in functional peptides which have antioxidant activity, immuneregulatory activity, and so on (Wang and Mejia 2005;Singh et al 2014). However, there is no study concerning effects of enzyme-treated plant protein on the protein saving in fish feeds.…”

Section: Introductionmentioning

confidence: 99%

Supplementation of enzyme-treated soy protein saves dietary protein and promotes digestive and absorptive ability referring to TOR signaling in juvenile fish

Xiao

Jiang

Feng

et al. 2017

Fish Physiol Biochem

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This study was conducted to evaluate the effect of enzyme-treated soy protein (ETSP) supplementation in the low-protein diet on growth performance, digestive and absorptive capacities, and related signaling molecules' gene expressions in juvenile Jian carp. The results showed that percent weight gain (PWG), specific growth rate (SGR), and feed intake (FI) were decreased by reducing dietary protein from 34 to 32% (P < 0.05). Supplying low-protein diet with optimal ETSP increased previously mentioned indices of juvenile Jian carp (P < 0.05), which also had no significant difference with the high-protein diet (34%CP) (P > 0.05). Compared with the low-protein diet, appropriate ETSP supplementation in the low-protein diet increased (P < 0.05) (1) the trypsin, lipase, and amylase activities in the hepatopancreas; (2) cholecystokinin concentration in the proximal intestine; (3) the γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (AKP), and Na + /K + -ATPase activities in all intestinal segments; and (4) the messenger RNA (mRNA) levels of trypsin, lipase, and amylase in hepatopancreas and γ-GT in the mid (MI) and distal (DI) intestine, alkaline phosphatase in MI, and Na + /K + -ATPase and target of rapamycin in all intestinal segments. At the same time, appropriate ETSP supplementation in the low-protein diet downregulated the mRNA levels of AKP in the DI and eIF4E-binding protein 2 in all intestinal segments (P < 0.05). In conclusion, adding 10 g ETSP/kg diet in the low-protein diet can restore the growth performance and digestive and absorptive abilities to the levels in group with 34% dietary protein. Supplementation of optimal ETSP in the low-protein diet enhanced the digestive and absorptive abilities and regulated the signaling molecules related to the TOR signaling pathway.

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“…Among the various peptides obtained by protein hydrolysis, soybean peptides offer the distinguishing advantages of being derived from an abundant and relatively inexpensive source of soybean proteins, and also exhibit various biological activities such as antihypertensive, anticholesterolemic, antioxidative, and anticancer activities 9 . Soy peptides obtained by hydrolysis also reportedly exhibit better emulsifying properties than that of native proteins 10 .…”

Section: Introductionmentioning

confidence: 99%