Functional Role of the Corticoreticular Pathway in Chronic Stroke Patients

Jang, Sung Ho; Chang, Chul Hoon; Lee, Jun; Kim, Chung Sun; Seo, Jeong Hyun; Yeo, Sang Seok

doi:10.1161/strokeaha.111.000269

Cited by 157 publications

(165 citation statements)

References 33 publications

(51 reference statements)

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“…22,23 By contrast, the tract number indicates the number of voxels contained within a neural tract. 24 As a result, the decrement of the tract number without a significant change of FA and apparent diffusion coefficient values of the lower ARAS suggests injury of the lower ARAS, and correlation between the tract number of the lower ARAS and GCS indicates a close relationship between the degree of injury of the lower ARAS and the consciousness level in patients with SAH. Previous studies have reported that nearly two-thirds of deaths following SAH were due to the initial hemorrhage, and most of these deaths happened during the first 2 days.…”

Section: Discussionmentioning

confidence: 88%

Aneurysmal Subarachnoid Hemorrhage Causes Injury of the Ascending Reticular Activating System: Relation to Consciousness

Jang

Kim

2015

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Little is known about the pathogenetic mechanism of impaired consciousness following subarachnoid hemorrhage. Using diffusion tensor imaging, we attempted to investigate the presence of injury of the lower portion of the ascending reticular activating system between the pontine reticular formation and the intralaminar thalamic nuclei, and the relation between this injury and consciousness level in patients with SAH.

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Section: Discussionmentioning

confidence: 88%

Aneurysmal Subarachnoid Hemorrhage Causes Injury of the Ascending Reticular Activating System: Relation to Consciousness

Jang

Kim

2015

AJNR Am J Neuroradiol

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“…Clarification of the cause of motor weakness is essential for prognosis and for adoption of scientific strategies for successful rehabilitation [22][23][24][25][26]. Recovery following a stroke is typically classified into neurological recovery and functional recovery; functional recovery is influenced by the external environment, continuity of rehabilitation, and motivation, whereas neurological recovery varies according to stroke pathogenesis and lesion site [27].…”

Section: Correlation Between Brain Lesion and Motor Recoverymentioning

confidence: 99%

“…The main function of the CST is control of movements of the distal extremities, particularly fine-motor movements of the hands [37,38], whereas the corticoreticulospinal tract, consisting of the corticoreticular pathway (CRP) and the reticulospinal tract, innervates the proximal extremities and axial muscles. Thus, it is involved in postural control and locomotor function [24,[39][40][41][42][43]. Therefore, determining the state of the CST and CRP is important for determining the cause of motor weakness in stroke patients.…”

Section: Correlation Between Brain Lesion and Motor Recoverymentioning

confidence: 99%

Prognosis and Recovery of Motor Function with Lesion–Symptom Mapping in Patients with Stroke

Lee

Lim

2017

Brain Neurorehabil

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Although studies have demonstrated that several specific brain lesions are related to the recovery and functional prognosis in patients with stroke, it still remained to be illusive. Modern imaging techniques make us possible to identify regions that are commonly related to specific deficit. Superimposing individual lesions to identify an area related to a particular function is based on the assumption that these functional modules are in the same location in different individuals. It is traditional to overlay plots using 'lesion subtraction.' Additionally, voxel-based lesion-symptom mapping (VLSM) can be used to determine relationships between behavioral measures and its neural correlates in the brain. VLSM estimates statistical parameters on a voxel-by-voxel basis by calculating the correlations between t-scores for tasks and treating voxels as subjects, allowing fairly high spatial precision. Understanding their relative merits with regard to specific brain lesions should be useful in planning rehabilitation strategies and will become an important part of neurorehabilitation.

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“…In patients with chronic stroke walking ability was correlated with corticoreticular pathway volume in the nonaffected hemisphere and this volume was higher in patients who recovered walking ability than in those who did not and even higher than in normal controls, thus supporting the view that these changes in the nonaffected hemisphere might indeed be compensatory. 23 …”

Section: Role Of Alternative Pathwaysmentioning

confidence: 99%