Functional role of ginseng-derived compounds in cancer

Abstract

Ginseng is a natural product best known for its curative properties in diverse physiological processes such as cancer, neurodegenerative disorders, hypertension, and maintenance of hemostasis in the immune system. In previous decades, there have been some promising studies into the pharmacology and chemistry of ginseng components and the relationship between their structure and function. The emerging use of modified ginseng and development of new compounds from ginseng for clinical studies have been topics of study for many researchers. The present review deals with the anticancer, anti-inflammatory, antioxidant, and chemopreventive effects, and recent advances in microRNA technology related to red ginseng. The review also summarizes the current knowledge on the effect of ginsenosides in the treatment of cancer.

Trichosanthes tricuspidata Lour. Methanol Extract Exhibits Anti-Inflammatory Activity by Targeting Syk, Src, and IRAK1 Kinase Activity

“…In Korea, medical expenditures related to gastritis and gastric ulcers range from $956.6 to $2553.10 per patient [59]. Moreover, traditional aromatic and herbal medicine has been used in Korea since ancient times to treat a variety of disorders including gastritis and ulcers [60]. We studied the effect of Tt-ME on HCl/EtOH-induced gastritis.…”

Regulation of 8-Hydroxydaidzein in IRF3-Mediated Gene Expression in LPS-Stimulated Murine Macrophages

“…Inflammatory processes are indeed a defense mechanism as part of an advanced ability of the body to maintain tissue homeostasis against harmful stimuli including pathogens as well as tissue injury, stress, and malfunction. In addition, inflammation, particularly chronic inflammation, is widely known to be a common pathogenesis of many chronic diseases such as chronic hepatitis, hepatocirrhosis, gastric ulcer, cardiovascular and bowel diseases, diabetes, arthritis, and cancer [1,8,9]. For instance, when acute inflammation fails to eliminate the source of an injury, the resolution of the inflammation cannot be achieved.…”

Analysis and Identification of Active Compounds from Salviae miltiorrhizae Radix Toxic to HCT-116 Human Colon Cancer Cells

“…Although surgery plays a key role in the diagnosis and treatment of colorectal cancer, there are still increasing attempts to stop the progression of this cancer via the application of new synthetic and naturally-occuring compounds [2,3]. Bioactive compounds from plants have been screened for anticancer activities [4,5]. Approximately 50-60% of cancer patients in the United States utilize complementary and alternative medicines with traditional therapeutic regimens, such as radiation therapy and chemotherapy [6].…”