Functional relationships among intrafollicular insulin-like growth factor 1, circulatory gonadotropins, and development of the dominant follicle in mares

Reversible downregulation of the hypothalamic-pituitary-gonadal axis in stallions with a novel GnRH antagonist

“…Although there are no reports of acyline administration to stallions, acyline administered (w10 mg/kg) to cyclic pony mares resulted in decreased peripheral FSH concentrations and retarded growth of the dominant follicle [27,28]. We hypothesized that acyline administration would result in downregulation of the HPG axis in stallions and that the effects of such blockade would be reversed after the end of treatment.…”