2006
DOI: 10.1615/critrevtherdrugcarriersyst.v23.i4.10
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Abstract: Nanotechnology is a multidisciplinary field and has achieved breakthroughs in bioengineering, molecular biology, diagnostics, and therapeutics. A recent advance in nanotechnology is the development of a functional nanosystem by incorporation, adsorption, or covalent coupling of polymers, carbohydrates, endogenous substances/ligands, peptides, proteins, nucleic acids, and polysaccharides to the surface of nanoparticles. Functionalization confers a wide array of interesting properties such as stealth characteris… Show more

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Cited by 135 publications
(72 citation statements)
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“…Measured values were then converted to particle sizes via the Stokes-Einstein relationship 36 . NIPAm particle size decreased with increasing temperature (Figure 2A), which is a distinctive characteristic of thermo responsive hydrogels [28][29][30][31][32][33] . The NIPAm/AAc particles showed a similar temperature dependence with respect to particle size, however they also demonstrated a pH dependent behavior ( Figure 2B).…”
Section: Hydrogel Particle Synthesis and Characterizationmentioning
confidence: 97%
“…Measured values were then converted to particle sizes via the Stokes-Einstein relationship 36 . NIPAm particle size decreased with increasing temperature (Figure 2A), which is a distinctive characteristic of thermo responsive hydrogels [28][29][30][31][32][33] . The NIPAm/AAc particles showed a similar temperature dependence with respect to particle size, however they also demonstrated a pH dependent behavior ( Figure 2B).…”
Section: Hydrogel Particle Synthesis and Characterizationmentioning
confidence: 97%
“…Compared with liposomes, polymeric NPs are more stable when in contact with the biological fluids. Also, their polymeric nature permits the attainment of desired properties such as controlled and sustained drug release, allowing drug release at the targeted site over a period of days or even weeks after injection (Garcia-Garcia et al 2005;Roney et al 2005;Nahar et al 2006). Drug release from NPs is mediated by drug desorption, diffusion through the NP matrix, polymer wall degradation of NPs or some combination of these mechanisms (Lockman et al 2002;Misra et al 2003).…”
Section: Polymeric Nanoparticlesmentioning
confidence: 99%
“…These advantages stem from two basic properties: 1) their small size favors penetration through small capillaries, allowing a greater accumulation of the drug /gene at the target site (Soppimath et al, 2001), this is particularly relevant in the CNS, in which the transport of some drugs is limited because of their inability to cross the BBB and 2) the application of nanoparticles as vehicles for transport of drugs / genes may help overcome this obstacle. In fact, it has recently been shown that polymeric nanoparticles are effective for the transport of peptides and other agents through the BBB (Kreuter et al, 2003;Nahar et al, 2006). The use of biodegradable polymers favors the sustained release of drugs / genes into the target site over a long period (Tang et al, 2009).…”
Section: Nanoparticles-based Vectors Crossing Blood Brain Barriermentioning
confidence: 99%