Biomaterials for the central nervous system

Zhong, Yinghui; Bellamkonda, Ravi V.

doi:10.1098/rsif.2008.0071

Cited by 202 publications

(157 citation statements)

References 212 publications

(394 reference statements)

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“…A challenging problem in chronic recordings is long-term stability of electrodes and recording sites, i.e., obtaining single-and multiunit activity even several months or years following implantation (Hatsopoulos and Donoghue 2009; Polikov et al 2005;Zhong and Bellamkonda 2008). Within cortical tissue, chronically implanted electrodes are likely to induce foreign body reactions like local inflammation processes (Biran et al 2005;McConnell et al 2009), encapsulation of the recording surface (Schmidt et al 1976;Szarowski et al 2003;Turner et al 1999), and formation of glial scars (Griffith and Humphrey 2006), thereby increasing electrode impedance (Grill and Mortimer 1994;Newbold et al 2004;Williams et al 2007) and the distance between electrode tips and nearby neurons (Liu et al 1999).…”

Section: Discussionmentioning

confidence: 99%

A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys

Galashan

Rempel

Meyer

et al. 2011

Journal of Neurophysiology

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“…In addition, there are various mechanical motions of adjacent muscles, which require deformations of the interfacing electrodes to preserve mechanically conformal contacts and prevent scar formation arisen from mechanical mismatch between biological tissues and MEA 33 . Furthermore, inflammations at interfaces between electrodes and nerves induced by reactive oxygen species (ROS) 34 must be suppressed, since massive inflammatory responses can cause death of nervous cells 35 and damage the peripheral nervous system. Corresponding electrophysiological responses recorded from the VPL of the thalamus in the right hemisphere (bottom).…”

Section: Nature Communications | Doimentioning

confidence: 99%

Stretchable silicon nanoribbon electronics for skin prosthesis

et al. 2014

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Sensory receptors in human skin transmit a wealth of tactile and thermal signals from external environments to the brain. Despite advances in our understanding of mechano-and thermosensation, replication of these unique sensory characteristics in artificial skin and prosthetics remains challenging. Recent efforts to develop smart prosthetics, which exploit rigid and/or semi-flexible pressure, strain and temperature sensors, provide promising routes for sensor-laden bionic systems, but with limited stretchability, detection range and spatiotemporal resolution. Here we demonstrate smart prosthetic skin instrumented with ultrathin, single crystalline silicon nanoribbon strain, pressure and temperature sensor arrays as well as associated humidity sensors, electroresistive heaters and stretchable multi-electrode arrays for nerve stimulation. This collection of stretchable sensors and actuators facilitate highly localized mechanical and thermal skin-like perception in response to external stimuli, thus providing unique opportunities for emerging classes of prostheses and peripheral nervous system interface technologies.

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“…Generally, poly(alkylcyanoacrylates) (PACAs), polyacetates, polysaccharides, and copolymers are used for NP synthesis (Garcia-Garcia et al 2005 ). For instance, drugs including dalargin, loperamide, tubocurarine, and doxorubicin have been delivered to the CNS by Polybutylcyanoacrylate (PBCA) NPs (Zhong and Bellamkonda 2008 ). NPs can also be coated with hydrophilic polymers, such as PEG, to increase their uptake (Brigger et al 2002 ).…”

Section: Materials Properties and Methods For Drug Deliverymentioning

confidence: 99%

“…Therefore, by combining the effect of PEG on extended circulation time and specifi city due to an antibody or a ligand conjugation, delivery can be obtained through the BBB. Liposomes have been used for the treatment of CNS diseases including brain tumors, infection, and ischemia (Zhong and Bellamkonda 2008 ).…”

Section: Materials Properties and Methods For Drug Deliverymentioning

confidence: 99%

Bioactive Nanomaterials for Neural Engineering

et al. 2016

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“…17,19,22,23 In order to enhance cell regeneration, scaffolds are often designed as platforms for the delivery of bioactive molecules such as growth factors, angiogenic factors, and differentiation factors. 1,2,24,25 For example, basal fibroblast growth factor (bFGF, also known as FGF-2) is a mitogenic polypeptide which induces cell divisions in a variety of cell types including skin, blood vessel, muscle, adipose, cartilage, and bone tissues. 26,27 It also promotes cell proliferation and differentiation in cultures of mouse and human olfactory epithelium.…”

Section: Introductionmentioning

confidence: 99%

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Ziv-Polat

Skaat²,

Shahar³

et al. 2012

IJN

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Novel tissue-engineered magnetic fibrin hydrogel scaffolds were prepared by the interaction of thrombin-conjugated iron oxide magnetic nanoparticles with fibrinogen. In addition, stabilization of basal fibroblast growth factor (bFGF) was achieved by the covalent and physical conjugation of the growth factor to the magnetic nanoparticles. Adult nasal olfactory mucosa (NOM) cells were seeded in the transparent fibrin scaffolds in the absence or presence of the free or conjugated bFGF-iron oxide nanoparticles. The conjugated bFGF enhanced significantly the growth and differentiation of the NOM cells in the fibrin scaffolds, compared to the same or even five times higher concentration of the free bFGF. In the presence of the bFGFconjugated magnetic nanoparticles, the cultured NOM cells proliferated and formed a threedimensional interconnected network composed mainly of tapered bipolar cells. The magnetic properties of these matrices are due to the integration of the thrombin-and bFGF-conjugated magnetic nanoparticles within the scaffolds. The magnetic properties of these scaffolds may be used in future work for various applications, such as magnetic resonance visualization of the scaffolds after implantation and reloading the scaffolds via magnetic forces with bioactive agents, eg, growth factors bound to the iron oxide magnetic nanoparticles.

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Biomaterials for the central nervous system

Cited by 202 publications

References 212 publications

A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys

Stretchable silicon nanoribbon electronics for skin prosthesis

Bioactive Nanomaterials for Neural Engineering

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

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