A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys

Galashan, F. Orlando; Rempel, Hanna C.; Meyer, Anneke; Gruber-Dujardin, Eva; Kreiter, Andreas K.; Wegener, Detlef

doi:10.1152/jn.00508.2010

Cited by 28 publications

(32 citation statements)

References 86 publications

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“…The dura mater consists of collagen fibres that are interdispersed with fibroblasts and elastin and is traversed by a network of blood vessels. In humans, its thickness varies from 0.3 to 0.8 mm, depending on the age of the individual 18,19 . Both cranial and spinal dura maters exhibit hyperelastic and viscoelastic stress-strain behaviour, typical of collagenous tissues, with an elastic modulus of 0.5-1.2 MPa (REF.…”

Section: Understanding Neural Materials Macroscopic and Morphologicalmentioning

confidence: 99%

Materials and technologies for soft implantable neuroprostheses

2016

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| Implantable neuroprostheses are engineered systems designed to restore or substitute function for individuals with neurological deficits or disabilities. These systems involve at least one uni-or bidirectional interface between a living neural tissue and a synthetic structure, through which information in the form of electrons, ions or photons flows. Despite a few notable exceptions, the clinical dissemination of implantable neuroprostheses remains limited, because many implants display inconsistent long-term stability and performance, and are ultimately rejected by the body. Intensive research is currently being conducted to untangle the complex interplay of failure mechanisms. In this Review, we emphasize the importance of minimizing the physical and mechanical mismatch between neural tissues and implantable interfaces. We explore possible materials solutions to design and manufacture neurointegrated prostheses, and outline their immense therapeutic potential. NATURE REVIEWS | MATERIALSADVANCE ONLINE PUBLICATION | 1 REVIEWS© 2 0 1 6 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .

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Section: Understanding Neural Materials Macroscopic and Morphologicalmentioning

confidence: 99%

Materials and technologies for soft implantable neuroprostheses

2016

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“…The dura mater in mammals is permeable to water, oxygen and carbon dioxide (Bernards, 1994; Maikos et al, 2008; Reina et al, 1994), and its thickness varies from tens of microns in mice to hundreds of microns in primates (Galashan et al, 2011). The relatively permeability of the dura mater allow the use of oxygen-sensitive materials on the outer surface of the dura mater, to monitor O2 dynamics in the brain tissue adjacent to it.…”

Section: Discussionmentioning

confidence: 99%

Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue

Tsytsarev

Akkentli

Pumbo

et al. 2017

Journal of Neuroscience Methods

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Background Brain imaging methods are continually improving. Imaging of the cerebral cortex is widely used in both animal experiments and charting human brain function in health and disease. Among the animal models, the rodent cerebral cortex has been widely used because of patterned neural representation of the whiskers on the snout and relative ease of activating cortical tissue with whisker stimulation. New Method We tested a new planar solid-state oxygen sensor comprising a polymeric film with a phosphorescent oxygen-sensitive coating on the working side, to monitor dynamics of oxygen metabolism in the cerebral cortex following sensory stimulation. Results Sensory stimulation led to changes in oxygenation and deoxygenation processes of activated areas in the barrel cortex. We demonstrate the possibility of dynamic mapping of relative changes in oxygenation in live mouse brain tissue with such a sensor. Comparison with Existing Method Oxygenation-based functional magnetic resonance imaging (fMRI) is very effective method for functional brain mapping but have high costs and limited spatial resolution. Optical imaging of intrinsic signal (IOS) does not provide the required sensitivity, and voltage-sensitive dye optical imaging (VSDi) has limited applicability due to significant toxicity of the voltage-sensitive dye. Our planar solid-state oxygen sensor imaging approach circumvents these limitations, providing a simple optical contrast agent with low toxicity and rapid application. Conclusions The planar solid-state oxygen sensor described here can be used as a tool in visualization and real-time analysis of sensory-evoked neural activity in vivo. Further, this approach allows visualization of local neural activity with high temporal and spatial resolution.

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“…Also, a design with eccentric electrode position which changed the penetration track many times in the same animal by placing the microdrive in the base at different orientations was used (Korshunov 1995). Recently, an implantable recording chamber for exchangeable electrode arrays has been designed (Galashan et al 2011). This overcomes the problem that the probability to record single units or even small multiunit clusters decreases in chronic recordings.…”

Section: Discussionmentioning

confidence: 99%

“…Investigators have developed techniques to record activity within the brain of behaving animals (Korshunov 1995;Kralik et al 2001;Battaglia et al 2009;Galashan et al 2011). These techniques usually involve electrodes attached to a device, in a manner that allows for their gradual advancement into the brain structure of interest.…”

Section: Introductionmentioning

confidence: 99%

A miniature microdrive for recording auditory evoked potentials from awake anurans

Mohammed

Radwan²,

Walkowiak³

et al. 2014

gpb

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Abstract. Electrical activity recording from the brains of awake animals is a corner stone in the study of the neurophysiological basis of behavior. To meet this need, a microelectrode driver suitable for the animal of interest has to be developed. In the present study a miniature microdrive was developed specifically for the leopard toad, Bufo regularis, however, it can be used for other small animals. The microdrive was designed to meet the following requirements: small size, light weight, simple and easy way of attaching and removing, advancing and withdrawing of microelectrode in the animal brain without rotation, can be reused and made from inexpensive materials. To assess the performance of the developed microdrive, we recorded auditory evoked potentials from different auditory centers in the toad's brain. The potentials were obtained from mesencephalic, diencephalic and telencephalic auditory sensitive areas in response to simple and complex acoustic stimuli. The synthetic acoustical tones introduced to the toad were carrying the dominant frequencies of their mating calls.

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A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys

Abstract: Galashan FO, Rempel HC, Meyer A, Gruber-Dujardin E, Kreiter AK, Wegener D. A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys.

Cited by 28 publications

References 86 publications

Materials and technologies for soft implantable neuroprostheses

Materials and technologies for soft implantable neuroprostheses

Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue

A miniature microdrive for recording auditory evoked potentials from awake anurans

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A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys

Abstract: Galashan FO, Rempel HC, Meyer A, Gruber-Dujardin E, Kreiter AK, Wegener D. A new type of recording chamber with an easy-to-exchange microdrive array for chronic recordings in macaque monkeys.

Cited by 28 publications

References 86 publications

Materials and technologies for soft implantable neuroprostheses

Materials and technologies for soft implantable neuroprostheses

Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue

A miniature microdrive for recording auditory evoked potentials from awake anurans

Contact Info

Product

Resources

About

A miniature microdrive for recording auditory evoked potentials from awake anurans