Functional polymeric nanoparticle decorated microcantilever sensor for specific detection of erythromycin

Okan, Meltem; Duman, Memed

doi:10.1016/j.snb.2017.10.098

Cited by 24 publications

(9 citation statements)

References 55 publications

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“…Thus, using the Rayleigh-Ritz method and according to equations (1)(2)(3)(4)(5)(6)(7)(8), the resonance frequency of microbeam after absorbing the nanoparticle can be expressed as:…”

Section: Dynamic Modeling Of Microbeams As Mass Sensorsmentioning

confidence: 99%

“…Later, Dammers et al [5] measured specific antigen-antibody interactions by detecting adhesion force using microbeam bending. Today, microbeams are generally used to load the target on the surface and to determine the change in the resonance frequency after mass loading [6][7][8]. The resonance frequency of microbeams decreases with mass and is positively correlated with the specific binding of antigen and antibody [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Effect of microbeam geometry on the nano-mass sensor performance

Ardali

Ghaderi

Raeiszadeh

2019

Mechanics & Industry

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Microbeams have a wide range of applications as sensors and actuators in nanotechnology, biotechnology, microelectromechanical systems, and optics. Given their micrometer dimensions, these beams make precision mass sensors of sub-nanogram accuracy. An important challenge regarding mass sensors is to enhance their sensitivity and accuracy. Considering the fact that, this type of sensor operates based on the resonance frequency variations caused by nanoparticle absorption in the dynamic mode, the geometry of the microbeam is considered an important parameter affecting their sensitivity. This paper studies the rectangular microbeam, which is one of the most commonly used types of mass sensors. Three main models were selected by applying inner and outer cuts on the microbeam, and vibrating simulation was carried out using ABAQUS software for a total of 36 mass sensor configurations with different aspect ratios. Simulation results in two selected rectangular microbeam models with outer cuts show the sensitivity of the microsensor increases with increased microbeam rigidity. The triangular hollow microbeam was found to be the best design among the four models selected to be used as mass sensors.

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“…Thus, using the Rayleigh-Ritz method and according to equations (1)(2)(3)(4)(5)(6)(7)(8), the resonance frequency of microbeam after absorbing the nanoparticle can be expressed as:…”

Section: Dynamic Modeling Of Microbeams As Mass Sensorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of microbeam geometry on the nano-mass sensor performance

Ardali

Ghaderi

Raeiszadeh

2019

Mechanics & Industry

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“…A number of antibiotics have been studied thus far. A common attention was paid mostly on quinolones such as ciprofloxacin, , macrolides such as erythromycin, tetracyclines, nitroimidazoles such as metronidazole, and amoxicillin from the penicillin family . However, there exist more antibiotics from various other families that also need to be studied.…”

Section: Introductionmentioning

confidence: 99%

Study on Cost-Efficient Carbon Aerogel to Remove Antibiotics from Water Resources

et al. 2020

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Because of pharmaceutical-emerging contaminants in water resources, there has been a significant increase in the antibiotic resistance in bacteria. Therefore, the removal of antibiotics from water resources is essential. Various antibiotics have been greatly studied using many different carbon-based materials including graphene-based hydrogels and aerogels. In this study, carbon aerogels (CAs) were synthesized from waste paper sources and their adsorption behaviors toward three antibiotics (hygromycin B, gentamicin, and vancomycin) were investigated, for which there exist a limited number of reports in the literature. The prepared CAs were characterized with scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and micro-computerized tomography (μ-CT). According to the μ-CT results, total porosity and open porosity were calculated as 90.80 and 90.76%, respectively. The surface area and surface-to-volume ratio were found as 795.15 mm 2 and 16.79 mm –1 , respectively. The specific surface area of the CAs was found as 104.2 m 2 /g. A detailed adsorption study was carried out based on different pH values, times, and analyte concentrations. The adsorption capacities were found as 104.16, 81.30, and 107.52 mg/g for Hyg B, Gen, and Van, respectively. For all three antibiotics, the adsorption behavior fits the Langmuir model. The kinetic studies showed that the system fits the pseudo-second-order kinetic model. The production of CAs, within the scope of this study, is safe, facile, and cost-efficient, which makes these green adsorbents a good candidate for the removal of antibiotics from water resources. This study represents the first antibiotic adsorption study based on CAs obtained from waste paper.

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“…It also showed a high selectivity against another antibiotic with a similar structure, enrofloxacin (ENF). In a separate study, the particle size of MIP nanoparticles was found to have a positive effect on the sensitivity 71 . A similar system incorporated with erythromycin (ERY) imprinted polymeric nanoparticles of 22 nm were found to have a higher sensitivity of 1.58 Hz pg –1 in concentration range 0.68–67.94 μmol L –1 .…”

Section: Combined Mmip Techniques For Analysismentioning

confidence: 90%

Recent developments on magnetic molecular imprinted polymers (MMIPs) for sensing, capturing, and monitoring pharmaceutical and agricultural pollutants

Aylaz

Kuhn

Lau

et al. 2021

J of Chemical Tech & Biotech

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Among the many classes of pollutants, bioactive contaminants including pesticides, herbicides, and other pharmaceutical active compounds (PhACs) are causing significant concern. These chemicals have been linked directly to contamination of freshwater and food sources, threatening water and food security. Contamination from antibiotics, one class of PhACs, is also considered to link strongly to the global problem of antimicrobial resistance (AMR). Pollution from these contaminants has hit developing countries harder as a consequence of less stringent legislation on waste discharge from agricultural industries. Current sampling and monitoring methods [e.g. liquid chromatography mass spectrometry (LC–MS)] are expensive, time‐consuming, immobile and require skilled users. Recent development of devices fitted with molecular imprinted polymers (MIPs) have been found to be particularly attractive owing to their low cost, stability, high selectivity and mobility. MIPs also can be used to extract these organic pollutants at low concentrations. The latest development of magnetic MIPs (MMIPs) further facilitates the separation and recovery of these absorbents by using an external magnetic field after the target molecules have been bound, thus avoiding laborious centrifugation and filtration for separation and recovery. The purpose of this perspective is to summarize the recent development of MMIPs in the past ten years. We will focus on their applications in food industries and the agricultural sector. Several potential developments in combined analytical techniques using MMIPs also will be discussed. As pollution to our environment is now a focal point in human life, new analytical techniques based on MMIPs will be of great interest to the science communities. © 2021 Society of Chemical Industry

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Functional polymeric nanoparticle decorated microcantilever sensor for specific detection of erythromycin

Cited by 24 publications

References 55 publications

Effect of microbeam geometry on the nano-mass sensor performance

Effect of microbeam geometry on the nano-mass sensor performance

Study on Cost-Efficient Carbon Aerogel to Remove Antibiotics from Water Resources

Recent developments on magnetic molecular imprinted polymers (MMIPs) for sensing, capturing, and monitoring pharmaceutical and agricultural pollutants

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