Functional Polymer Nanocarriers for Photodynamic Therapy

Li, Tuanwei; Yan, Lifeng

doi:10.3390/ph11040133

Cited by 33 publications

(26 citation statements)

References 205 publications

(291 reference statements)

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“…PDT and PTT have gained much attention based on their effectiveness in cancer treatment [7,43,151,152]. Combination treatment with chemotherapy, PDT, and PTT using multifunctional PLGA NPs has been investigated.…”

Section: In Vivo Anticancer Activities Of Plga-based Npsmentioning

confidence: 99%

Recent Progress in the Development of Poly(lactic-co-glycolic acid)-Based Nanostructures for Cancer Imaging and Therapy

et al. 2019

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Diverse nanosystems for use in cancer imaging and therapy have been designed and their clinical applications have been assessed. Among a variety of materials available to fabricate nanosystems, poly(lactic-co-glycolic acid) (PLGA) has been widely used due to its biocompatibility and biodegradability. In order to provide tumor-targeting and diagnostic properties, PLGA or PLGA nanoparticles (NPs) can be modified with other functional materials. Hydrophobic or hydrophilic therapeutic cargos can be placed in the internal space or adsorbed onto the surface of PLGA NPs. Protocols for the fabrication of PLGA-based NPs for cancer imaging and therapy are already well established. Moreover, the biocompatibility and biodegradability of PLGA may elevate its feasibility for clinical application in injection formulations. Size-controlled NP’s properties and ligand–receptor interactions may provide passive and active tumor-targeting abilities, respectively, after intravenous administration. Additionally, the introduction of several imaging modalities to PLGA-based NPs can enable drug delivery guided by in vivo imaging. Versatile platform technology of PLGA-based NPs can be applied to the delivery of small chemicals, peptides, proteins, and nucleic acids for use in cancer therapy. This review describes recent findings and insights into the development of tumor-targeted PLGA-based NPs for use of cancer imaging and therapy.

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Section: In Vivo Anticancer Activities Of Plga-based Npsmentioning

confidence: 99%

Recent Progress in the Development of Poly(lactic-co-glycolic acid)-Based Nanostructures for Cancer Imaging and Therapy

et al. 2019

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“…Consequently, they create difficulties related to low photostability leading to ineffective delivery and poor bioavailability after transdermal, intravenous or oral administration. Taking that into consideration, it has become very important to provide high photosensitivity and sufficient protection of these delicate compounds from the external environment [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

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The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of “soft” nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and “smart” vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Encapsulation of photosensitive agents such as drugs, dyes, photosensitizers or antioxidants can be specifically formulated by the self-assembly of phospholipids or other amphiphilic compounds. They are intended to match unique pharmaceutic and cosmetic requirements and to improve their delivery to the target site via the most common, i.e., transdermal, intravenous or oral administration routes. Numerous surface modifications and functionalization of the nanostructures allow increasing their effectiveness and, consequently, may contribute to the treatment of many diseases, primarily cancer. An increasing article number is evidencing significant advances in applications of the different classes of the photosensitive agents incorporated in the ”soft” colloidal nanocarriers that deserved to be highlighted in the present review.

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“…Developed in its modern form by Dougherty in the 1970's [17], PDT is currently clinically employed in dermatology (e.g., for actinic keratinosis), ophthalmology (e.g., for age-related macular degeneration) or oncology (e.g., for skin, retina, bladder, gastronintestinal, prostate, lung, head and neck cancers). However, as reported by Zhang et al in a recent review [18], clinical development of PDT remains somewhat limited because of various challenges, ranging from photosensitizer formulation, light dosimetry, to planning and monitoring the treatment [15,[18][19][20][21][22]. Some of these points have been recently reviewed: ideal photosensitizers [23], challenges in formulating photosensitizers, and choosing the right light dosimetry [24], as well as monitoring the treatment response [25].…”

Section: Introductionmentioning

confidence: 99%

Rational design of block copolymer self-assemblies in photodynamic therapy

Demazeau¹,

Gibot²,

Mingotaud³

et al. 2020

Beilstein J. Nanotechnol.

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Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

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Functional Polymer Nanocarriers for Photodynamic Therapy

Cited by 33 publications

References 205 publications

Recent Progress in the Development of Poly(lactic-co-glycolic acid)-Based Nanostructures for Cancer Imaging and Therapy

Recent Progress in the Development of Poly(lactic-co-glycolic acid)-Based Nanostructures for Cancer Imaging and Therapy

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

Rational design of block copolymer self-assemblies in photodynamic therapy

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