Recent Progress in the Development of Poly(lactic-co-glycolic acid)-Based Nanostructures for Cancer Imaging and Therapy

Abstract

Diverse nanosystems for use in cancer imaging and therapy have been designed and their clinical applications have been assessed. Among a variety of materials available to fabricate nanosystems, poly(lactic-co-glycolic acid) (PLGA) has been widely used due to its biocompatibility and biodegradability. In order to provide tumor-targeting and diagnostic properties, PLGA or PLGA nanoparticles (NPs) can be modified with other functional materials. Hydrophobic or hydrophilic therapeutic cargos can be placed in the internal space or adsorbed onto the surface of PLGA NPs. Protocols for the fabrication of PLGA-based NPs for cancer imaging and therapy are already well established. Moreover, the biocompatibility and biodegradability of PLGA may elevate its feasibility for clinical application in injection formulations. Size-controlled NP’s properties and ligand–receptor interactions may provide passive and active tumor-targeting abilities, respectively, after intravenous administration. Additionally, the introduction of several imaging modalities to PLGA-based NPs can enable drug delivery guided by in vivo imaging. Versatile platform technology of PLGA-based NPs can be applied to the delivery of small chemicals, peptides, proteins, and nucleic acids for use in cancer therapy. This review describes recent findings and insights into the development of tumor-targeted PLGA-based NPs for use of cancer imaging and therapy.

Investigating Novel Syntheses of a Series of Unique Hybrid PLGA-Chitosan Polymers for Potential Therapeutic Delivery Applications

“…(3) capable of producing both nanosystems or polymeric scaffolds; (4) chemically modifiable to include stealthing moieties (polyethylene glycol, PEG) and/or targeting ligands. All of these aspects have been widely exploited in production of PLGA nanoparticles (NPs) for the possible cure of a plethora of diseases [13][14][15][16][17][18].…”

Efficient Delivery of Transducing Polymer Nanoparticles for Gene-Mediated Induction of Osteogenesis for Bone Regeneration

“…Our demonstration here provides the foundation for developing future first-in-class pharmaceutical gene therapy product. However, such PLGA NPs poorly internalize and yield almost no transfection levels in vitro or in vivo when adequately removing and controlling for contaminating nucleic acids left from the fabrication process (Torchilin, 2008;Steinbach et al, 2016;Kim et al, 2019).…”

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

“…According to the industrial consideration, there are many procedures for fabricating PLGA nanoparticles. Most of these techniques are easy to scale-up (Kim et al, 2019). The drug release and degradation rate can be tuned and controlled by changing the ratio of lactic acid and glycolic acid.…”