Functional optical coherence tomography: principles and progress

Kim, Jina; Brown, William J.; Maher, Jason R.; Levinson, Howard; Wax, Adam

doi:10.1088/0031-9155/60/10/r211

Cited by 93 publications

(58 citation statements)

References 104 publications

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“…Recent advances in OCT technology have led to the development of so-called functional-OCT technologies [99], including Doppler OCT for the assessment of retinal blood flow and polarisation OCT for the assessment of birefringent tissues, such as ganglion cell axon densities [106]. Improvements to the underlying OCT technology have led to the development of swept source (SS)-OCT [168], Adaptive Optics (AO)-OCT [126], and Frequency-Domain (FD)-OCT [128].…”

Section: Techniques For Monitoring Retinal Ganglion Cell Healthmentioning

confidence: 99%

Glaucoma: the retina and beyond

Davis¹,

Crawley

Pahlitzsch³

et al. 2016

Acta Neuropathol

231

151

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Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy, which is estimated to be responsible for 8.4 million cases of irreversible blindness globally. Glaucoma is associated with characteristic damage to the optic nerve and patterns of visual field loss which principally involves the loss of retinal ganglion cells (RGCs). At present, intraocular pressure (IOP) presents the only modifiable risk factor for glaucoma, although RGC and vision loss can continue in patients despite well-controlled IOP. This, coupled with the present inability to diagnose glaucoma until relatively late in the disease process, has led to intense investigations towards the development of novel techniques for the early diagnosis of disease. This review outlines our current understanding of the potential mechanisms underlying RGC and axonal loss in glaucoma. Similarities between glaucoma and other neurodegenerative diseases of the central nervous system are drawn before an overview of recent developments in techniques for monitoring RGC health is provided, including recent progress towards the development of RGC specific contrast agents. The review concludes by discussing techniques to assess glaucomatous changes in the brain using MRI and the clinical relevance of glaucomatous-associated changes in the visual centres of the brain.

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Section: Techniques For Monitoring Retinal Ganglion Cell Healthmentioning

confidence: 99%

Glaucoma: the retina and beyond

Davis¹,

Crawley

Pahlitzsch³

et al. 2016

Acta Neuropathol

231

151

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“…However, the authors only used the suggested design for Doppler OCT and optical coherence angiography imaging. We refer interested readers to [33,34] for a more detailed discussion on each of these techniques. Nonetheless, a broader range of research questions can be addressed by combining SD-OCT imaging techniques with other modalities such as fluorescence microscopy or electrophysiology.…”

Section: Introductionmentioning

confidence: 99%

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Atry

Rosa

Rarick

et al. 2018

International Journal of Optics

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In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.

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“…Since scattering and reflection is a result of refractive index changes, OCT is particularly sensitive to refractive index inhomogeneity in a material. Currently, the majority of OCT applications are in biomedical imaging of the eye and other biological tissues such as the skin [4,5]. Since 2004, OCT has been successfully applied to a variety of cultural heritage [6][7][8][9] [19] and corrosion layer in metal-based artefacts [20].…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography and non-linear microscopy for paintings – a study of the complementary capabilities and laser degradation effects

Liang¹,

Mari²,

Cheung³

et al. 2017

Opt. Express

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This paper examines for the first time the potential complementary imaging capabilities of Optical coherence tomography (OCT) and non-linear microscopy (NLM) for multi-modal 3D examination of paintings following the successful application of OCT to the in situ, non-invasive examination of varnish and paint stratigraphy of historic paintings and the promising initial studies of NLM of varnish samples. OCT provides image contrast through the optical scattering and absorption properties of materials, while NLM provides molecular information through multi-photon fluorescence and higher harmonics generation (second and third harmonic generation). OCT is well-established in the in situ non-invasive imaging of the stratigraphy of varnish and paint layers. While NLM examination of transparent samples such as fresh varnish and some transparent paints showed promising results, the ultimate use of NLM on paintings is limited owing to the laser degradation effects caused by the high peak intensity of the laser source necessary for the generation of nonlinear phenomena. The high intensity normally employed in NLM is found to be damaging to all non-transparent painting materials from slightly scattering degraded varnish to slightly absorbing paint at the wavelength of the laser excitation source. The results of this paper are potentially applicable to a wide range of materials given the diversity of the materials encountered in paintings (e.g. minerals, plants, insects, oil, egg, synthetic and natural varnish).

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Functional optical coherence tomography: principles and progress

Cited by 93 publications

References 104 publications

Glaucoma: the retina and beyond

Glaucoma: the retina and beyond

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Optical coherence tomography and non-linear microscopy for paintings – a study of the complementary capabilities and laser degradation effects

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