Functional MRI: The Environment and Technology for Clinical Application

Thulborn, Keith R.; McCurtain, B.J.; Voyvodic, James T.; Chang, Sam; Gillen, Joseph; Sweeney, John A.

doi:10.1007/978-88-470-2194-5_4

Cited by 5 publications

(7 citation statements)

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“…An oculomotor paradigm requiring eye movement was used to test the sighting visor device (16,18). This visually guided saccade task (19) was chosen, as the sighting system may be expected to disrupt this activation pattern due to distraction from the eye movement task associated with the sighting system.…”

Section: Imaging Protocolmentioning

confidence: 99%

“…MR imaging was performed on either a 1.5 or 3.0 T whole-body scanner (55 cm clear bore magnet Signa; General Electric Medical Systems, Milwaukee, WI) equipped with resonant gradient EPI (Advanced NMR Systems, Wilmington, MA) and data handling capabilities designed for fMRI as previously described (8,16). Gradientecho EPI (17) at 1.5 T used acquisition parameters as follows: TR 3000 msec, TE 50 msec, field of view (FOV) 40 ϫ 20, voxel size 3.1 ϫ 3.1 ϫ 5.0 mm 3 , slice thickness/gap 5/1 mm, and number of slices 9.…”

Section: Imaging Protocolmentioning

confidence: 99%

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Visual feedback to stabilize head position for fMRI

Thulborn

1999

Magn. Reson. Med.

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Head motion is a common cause of technical failure in functional magnetic resonance imaging. A simple visual alignment system has been developed to provide visual feedback to the subject about his or her head position. The subject is able to readjust his or her head position accurately during a study, should motion occur. This sighting system is incorporated into a visor that fits onto the commercial head coil. The accuracy of correcting head motion and activation maps obtained with this device are demonstrated. The cognitive workload of using the alignment system does not significantly alter the activation pattern associated with eye movement paradigms.

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Section: Imaging Protocolmentioning

confidence: 99%

Section: Imaging Protocolmentioning

confidence: 99%

Visual feedback to stabilize head position for fMRI

Thulborn

1999

Magn. Reson. Med.

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“…Data acquisition is readily and effidata into and out of the scan room, thereby producing no degradaciently achieved by the MR technologist on this system. tion in the SNR of the images [22,33,46,47]. The color highAs the data from this comprehensive protocol are of various resolution LCD projector is enclosed in an RF isolation cabinet types including conventional MRI, EPI, and TPI, efficient autoand projects visual stimuli via a lens onto a rear-projection screen mated analysis requires conversion to a common format.…”

Section: Synchronization Control System (Scs)mentioning

confidence: 99%

“…To calibrate the responses of the various maps, four maps are derived using software customized to superimpose graduated color regions of activation/deactivation, calculated using a tubes containing the calibration solutions (30-40 mM NaCl, 80-100 mM NaCl, 50% deuterated H 2 O, and 100% H 2 O) were placed two-tailed Student t test [49], over gray-scale anatomic images [33,47]. The maps can be viewed in a tiled multislice format or around the inside of the RF coil.…”

Section: Analysis and Viewingmentioning

confidence: 99%

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Functional, physiological, and metabolic toolbox for clinical magnetic resonance imaging: Integration of acquisition and analysis strategies

Thulborn

Uttecht

Betancourt

et al. 1997

Int. J. Imaging Syst. Technol.

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Selected neuroimaging strategies have been integrated into a clinical brain imaging protocol to provide quantitative high‐resolution functional, physiological, and metabolic maps to complement exquisitely detailed anatomic images without excessively prolonging the conventional clinical examination or analysis time. The physiological maps of blood pool parameters (relative cerebral blood volume, tissue transit time, and arrival time), apparent diffusion coefficient, tissue water content, and functional neuronal activation maps are derived from series of images acquired with echo‐planar imaging. The metabolic map reflecting tissue sodium homeostasis (tissue sodium concentration) is acquired using twisted projection imaging and a customized dual‐tuned, dual‐quadrature 23Na/1H brain radiofrequency coil that ensures coregistration of data and avoids moving the patient. The different types of acquired images are transferred to a common file format with customized file management software and the corresponding maps are derived by applying appropriate fitting algorithms. Customized software allows rapid interrogation and manipulation of all resultant images and maps for detailed but rapid interpretation, printing, and archiving immediately following completion of acquisition. As all acquisitions and processing are performed by the magnetic resonance technologist, the neuroradiologist is able to focus on the interpretation of this immensely rich data set. © 1997 John Wiley & Sons, Inc. Int J Imaging Syst Technol, 8, 572–581, 1997

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