Functional MRI in Prostate Cancer Detection

Sankineni, Sandeep; Osman, Murat; Choyke, Peter L.

doi:10.1155/2014/590638

Cited by 23 publications

(27 citation statements)

References 51 publications

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“…Distinct from the “anatomic” sequences, the “functional” mpMRI sequences are comprised of DWI MRI and DCE MRI . The DWI reflects the degree of water diffusion in the prostate.…”

Section: What Is Mpmri?mentioning

confidence: 99%

“…DWI is the recommended dominant sequence in PI‐RADS 2.0 for the peripheral zone, where the majority of prostate cancers occur. The degree of diffusion restriction reflects the aggressiveness of the prostate cancer, with lower ADCs associated with higher grade tumors . However, the ADC value is not sufficient to characterize prostate lesions, as there is considerable overlap among cancers of different Gleason scores with regard to their ADC.…”

Section: What Is Mpmri?mentioning

confidence: 99%

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Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer

Türkbey

Brown

Sankineni

et al. 2015

CA A Cancer J Clinicians

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140

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Imaging has traditionally played a minor role in the diagnosis and staging of prostate cancer. However, recent controversies generated by the use of prostate-specific antigen (PSA) screening followed by random biopsy have encouraged the development of new imaging methods for prostate cancer. Multiparametric magnetic resonance imaging (mpMRI) has emerged as the imaging method best able to detect clinically significant prostate cancers and to guide biopsies. Here, the authors explain what mpMRI is and how it is used clinically, especially with regard to high-risk populations, and we discuss the impact of mpMRI on treatment decisions for men with prostate cancer. CA Cancer J Clin 2016;66:326-336. © 2015 American Cancer Society.

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“…Distinct from the “anatomic” sequences, the “functional” mpMRI sequences are comprised of DWI MRI and DCE MRI . The DWI reflects the degree of water diffusion in the prostate.…”

Section: What Is Mpmri?mentioning

confidence: 99%

Section: What Is Mpmri?mentioning

confidence: 99%

Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer

Türkbey

Brown

Sankineni

et al. 2015

CA A Cancer J Clinicians

Self Cite

140

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“…In a systematic review on the use of MRI in men with low-risk or intermediate-risk prostate cancer who were considered suitable for AS, MRI was demonstrated to be useful for the detection of clinically significant disease at initial clinical assessment of men considering AS 18 . In addition, MRI might be useful for confirming the absence of any large anterior lesions that could have been missed during routine diagnosis 19 . However, robust, formally published data are needed before widespread implementation of MRI for this purpose 18,20 .…”

Section: Strengths and Weaknessesmentioning

confidence: 99%

Semantics in active surveillance for men with localized prostate cancer — results of a modified Delphi consensus procedure

et al. 2017

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| Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of terms related to this management option. An iterative three-round sequence of online questionnaires designed to address 61 individual items was completed by each panel member. Consensus was considered to be reached if ≥70% of the experts agreed on a definition. To facilitate a common understanding among all experts involved and resolve potential ambiguities, a face-to-face consensus meeting was held between Delphi survey rounds two and three. Convenience sampling was used to construct the panel of experts. In total, 12 experts from Australia, France, Finland, Italy, the Netherlands, Japan, the UK, Canada and the USA participated. By the end of the Delphi process, formal consensus was achieved for 100% (n = 61) of the terms and a glossary was then developed. Agreement between international experts has been reached on relevant terms and subsequent definitions regarding AS for patients with localized prostate cancer. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.312 | MAY 2017 | VOLUME 14 www.nature.com/nrurol CONSENSUS STATEMENT © 2 0 1 7 M a c m i l l a n P u b l i s h e r s L i m i t e d , p a r t o f S p r i n g e r N a t u r e . A l l r i g h t s r e s e r v e d .degree of monitoring than those on AS might receive, and in which palliative treatment is generally instituted if metastases or local symptoms develop. Interpreting and comparing research results is difficult owing to the nonstandardized use of the terms AS and WW and their intended and often mixed treatment objectives (curative or palliative) 5 . This semantic heterogeneity is also reflected in AS guidelines 6 . In these guidelines, AS is primarily recommended for patients with low-risk tumours; however, these guidelines contain various definitions of low-risk prostate cancer, as specified by different combinations of clinical criteria including clinical and pathological characteristics (such as tumour stage, serum PSA levels, biopsy Gleason score, tumour volume and serum PSA density). Furthermore, definitions of disease reclassification and progression differ among published guidelines and multiple criteria for initiation of curative treatment are proposed 6 .Problems resulting from the use of ambiguous language include hindered clinical decision making, particularly in multidisciplinary collaborations, and limited opportunities for research 7 . Moreover, such ambiguity has raised a barrier that hampers exchange of knowledge within and between fundamental domains of research and research groups 8 . An urgent need exists for uniform...

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“…4 Usually, the examination is performed on a 1.5T or 3T MRI scanner with or without the use of an endorectal coil (ERC). 5 The T2W sequence is used to determine the anatomical boundaries between the prostate zones and extend of tumor growth, e.g., extraprostatic extension or growth into the seminal vesicles. 4 The functional sequences are especially advantageous in PCa detection, evaluation of treatment response, and staging.…”

Section: Introductionmentioning

confidence: 99%

Prostate zonal segmentation in 1.5T and 3T T2W MRI using a convolutional neural network

et al. 2019

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Zonal segmentation of the prostate gland using magnetic resonance imaging (MRI) is clinically important for prostate cancer (PCa) diagnosis and image-guided treatments. A two-dimensional convolutional neural network (CNN) based on the U-net architecture was evaluated for segmentation of the central gland (CG) and peripheral zone (PZ) using a dataset of 40 patients (34 PCa positive and 6 PCa negative) scanned on two different MRI scanners (1.5T GE and 3T Siemens). Images were cropped around the prostate gland to exclude surrounding tissues, resampled to 0.5 × 0.5 × 0.5 mm voxels and z-score normalized before being propagated through the CNN. Performance was evaluated using the Dice similarity coefficient (DSC) and mean absolute distance (MAD) in a fivefold cross-validation setup. Overall performance showed DSC of 0.794 and 0.692, and MADs of 3.349 and 2.993 for CG and PZ, respectively. Dividing the gland into apex, mid, and base showed higher DSC for the midgland compared to apex and base for both CG and PZ. We found no significant difference in DSC between the two scanners. A larger dataset, preferably with multivendor scanners, is necessary for validation of the proposed algorithm; however, our results are promising and have clinical potential.

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Functional MRI in Prostate Cancer Detection

Cited by 23 publications

References 51 publications

Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer

Multiparametric prostate magnetic resonance imaging in the evaluation of prostate cancer

Semantics in active surveillance for men with localized prostate cancer — results of a modified Delphi consensus procedure

Prostate zonal segmentation in 1.5T and 3T T2W MRI using a convolutional neural network

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