Functional Motor Nerve Regeneration Without Motor-Sensory Specificity Following End-to-Side Neurorrhaphy: An Experimental Study

Yu, Qing; Lin, Zhong-Ke; Ding, Jian; Wang, Tao; Chi, Yong-Long; Gao, Weiyang

doi:10.1016/j.jhsa.2011.09.008

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…Yu et al evaluated end-to-side neurorrhaphy in the ulnar nerve as the donor and in the musculocutaneous nerve as the recipient and noted collateral sprouting of intact axons of the ulnar nerve with limited functional reinnervation32 . The development of novel microsurgical techniques and instrumentation led some to promote grouped fascicular repair.…”

mentioning

confidence: 99%

Peripheral Nerve Repair and Reconstruction

Griffin¹,

Hogan²,

Chhabra³

et al. 2013

The Journal of Bone & Joint Surgery

239

159

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When possible, direct repair remains the current standard of care for the repair of peripheral nerve lacerations. In large nerve gaps, in which direct repair is not possible, grafting remains the most viable option. Nerve scaffolds include autologous conduits, artificial nonbioabsorbable conduits, and bioabsorbable conduits and are options for repair of digital nerve gaps that are <3 cm in length. Experimental studies suggest that the use of allografts may be an option for repairing larger sensory nerve gaps without associated donor-site morbidity.

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mentioning

confidence: 99%

Peripheral Nerve Repair and Reconstruction

Griffin¹,

Hogan²,

Chhabra³

et al. 2013

The Journal of Bone & Joint Surgery

239

159

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show abstract

“…This is consistent with our previous report. 6 There are some limitations of our study. There is incomplete analysis of the mechanism leading to regeneration of the distal biceps brachii branch of the musculocutaneus nerve which was sutured end-to-side to the ulnar nerve.…”

Section: Discussionmentioning

confidence: 91%

“…The digitalized sections were analyzed with the use of Leica FW4000 (Soft Imaging System, Leica) in combination to a computer macro based on this software. 6 On the entire cross-sectional area, the total number of regenerated myelinated axons and diameter in micrometers was determined.…”

Section: Analysis Of Nerve Tissuementioning

confidence: 99%

Quantitative Assessment of the Motor-Sensory Specificity of the Motor and Primary Sensory Neurons after the End-to-Side Neurorrhaphy

Chen

Zhang

et al. 2013

J reconstr Microsurg

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We sought to evaluate the motor-sensory specificity of the motor and primary sensory neurons after the end-to-side neurorrhaphy. We divided 90 rats into three groups: (1) end-to-side neurorrhaphy using the ulnar nerve as donor nerve and the musculocutaneous nerve as recipient nerve; (2) normal control; and (3) transected nerve with the stumps buried. At 5 months, we monitored the grooming test, the electromyographic recordings, the histologic changes in the nerve, and quantitatively evaluated motoneurons and dorsal root ganglion (DRG) neurons following their retrograde labeling by Fluoro-Gold (Sigma, St. Louis, MO) applied to the musculocutaneous nerve and its biceps brachii branch. Grooming and electrophysiological investigations recovered successfully in the end-to-side group. The implanted musculocutaneous nerve contained varying but satisfactory numbers of axons. In the end-to-side group, the proportion of motoneurons for the biceps brachii branch of musculocutaneous nerve was very similar to the musculocutaneous nerve sections proximal to this branch (17.3% ± 2.7% and 21.7% ± 3.7%, respectively), but it did not correspond with the proportion of the biceps brachii branch of musculocutaneous nerve in the normal group (28.3% ± 3.5%). The present study confirms that limited but functional reinnervation can occur after the end-to-side neurorrhaphy, and the motor-sensory specificity is not important.

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“…Many authors have confirmed neurotropism and the budding or invasion of the distal stump by axons from the donor nerve 8 – 17 . Reinnervation also occurs with antagonistic nerves 18 and from sensitive nerve to motor nerve 19 , with or without epineurium window 8 , 9 , 20 , 21 .…”

Section: Introductionmentioning

confidence: 99%