Functional mapping of left parietal areas involved in simple addition and multiplication. A single‐case study of qualitative analysis of errors

Puppa, Alessandro Della; Pellegrin, Serena De; Salillas, Elena; Grego, Alberto; Lazzarini, A.L. Fantola; Vallesi, Antonino; Saladini, Marina; Semenza, Carlo

doi:10.1111/jnp.12043

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…However, while it is clear that mental calculation is connected to several cognitive processes, information about cerebral areas involved in different calculation processes is still relatively limited. Indeed, despite several attempts to investigate the causal role of brain regions involved in simple mental calculation (e.g., Andres et al, 2011;Della Puppa et al, 2015b;Maurer et al, 2015;Salillas et al, 2012), few studies have addressed this issue on more complex mental calculation (e.g., De Smedt et al, 2009;Grabner et al, 2015). This issue is particularly important because of a crucial difference between simple and complex mental calculation that is not merely quantitative.…”

Section: Introductionmentioning

confidence: 99%

“…With the same goal, recent studies conducted with direct cortical electrostimulation (DCE) found a role of specific RH areas in simple addition and multiplication (Della Puppa et al, 2013;Della Puppa et al, 2015a;Della Puppa et al, 2015b;Duffau et al, 2002;Roux et al, 2009;Semenza et al, 2016) and subtractions (Yu et al, 2011). Finally, by means of a technique similar to rTMS and DCE (i.e., transcranial direct current stimulation, tDCS) and focusing on the acquisition of mathematical knowledge, Grabner and colleagues (2015) demonstrated that the left posterior parietal cortex is causally involved in arithmetic learning of two-digit operations.…”

Section: Introductionmentioning

confidence: 99%

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Causal role of the posterior parietal cortex for two-digit mental subtraction and addition: A repetitive TMS study

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Causal role of the posterior parietal cortex for two-digit mental subtraction and addition: A repetitive TMS study

et al. 2017

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“…Stimulation of the right parietal lobe impaired simple subtraction ( Yu et al, 2011 ). Later studies identified positive sites in the right hemisphere also in addition, in the supramarginal gyrus, and in multiplication, in the angular gyrus, the supramarginal gyrus, the interparietal sulcus and the superior parietal lobule ( Della Puppa et al, 2013 , 2015 ). Crucial information came from the analysis of substitution errors (omissions were less than 5%; Semenza et al, 2017 ).…”

Section: Lesion Casesmentioning

confidence: 97%

The brain lateralization and development of math functions: progress since Sperry, 1974

Salillas,

Benavides-Varela,

Semenza

2023

Front. Hum. Neurosci.

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In 1974, Roger Sperry, based on his seminal studies on the split-brain condition, concluded that math was almost exclusively sustained by the language dominant left hemisphere. The right hemisphere could perform additions up to sums less than 20, the only exception to a complete left hemisphere dominance. Studies on lateralized focal lesions came to a similar conclusion, except for written complex calculation, where spatial abilities are needed to display digits in the right location according to the specific requirements of calculation procedures. Fifty years later, the contribution of new theoretical and instrumental tools lead to a much more complex picture, whereby, while left hemisphere dominance for math in the right-handed is confirmed for most functions, several math related tasks seem to be carried out in the right hemisphere. The developmental trajectory in the lateralization of math functions has also been clarified. This corpus of knowledge is reviewed here. The right hemisphere does not simply offer its support when calculation requires generic space processing, but its role can be very specific. For example, the right parietal lobe seems to store the operation-specific spatial layout required for complex arithmetical procedures and areas like the right insula are necessary in parsing complex numbers containing zero. Evidence is found for a complex orchestration between the two hemispheres even for simple tasks: each hemisphere has its specific role, concurring to the correct result. As for development, data point to right dominance for basic numerical processes. The picture that emerges at school age is a bilateral pattern with a significantly greater involvement of the right-hemisphere, particularly in non-symbolic tasks. The intraparietal sulcus shows a left hemisphere preponderance in response to symbolic stimuli at this age.

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“…1c, d) were shown just anteriorly [1,2] and laterally [3] to the tumor; 1 site involved in multiplication (Fig. 1e) was shown just medially to the tumor.…”

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confidence: 99%

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Functional MRI and calculation processing: considerations on preliminary experience about intra-operative validation by electro-stimulation

et al. 2015

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We recently reported our experience on functional mapping for calculation processing [1][2][3]. The numerical processing is a crucial function in daily life and its preservation can be achieved in patients undergoing neurosurgery. Indeed, it is well known the role of functional magnetic resonance imaging (fMRI) in surgical planning in patients affected by a brain tumor located in an eloquent area [4,5] as well as in the detection of structural and functional brain changes in patients with Parkinson's disease [6]. However, the fMRI reliability to detect functional sites for calculation in these patients is unclear because we are currently lacking of data on the correspondence between preoperative fMRI and intra-operative findings. A 47-year-old male patient affected by a small right parietal brain tumor recently came to our attention (Fig. 1a, b). Preoperatively, the patient underwent fMRI (3T Ingenia Philips scanner) with 16-s blocks of single-digit additions or multiplications and a control counting task. We focused on both one-digit addition and multiplication because they are the most basic of calculation tasks and their sparing is intuitively essential to perform higher order calculation.The fMRI showed some functional sites for calculation in the right superior lobule of the parietal cortex: three sites involved in addition (Fig. 1c, d) were shown just anteriorly [1, 2] and laterally [3] to the tumor; 1 site involved in multiplication (Fig. 1e) was shown just medially to the tumor. The patient then underwent the surgical resection of the parietal tumor. The approach and intra-operative mapping were performed as previously described [1,2]. The same calculation tasks used for fMRI were administered during surgery. Remarkably, we intra-operatively noted that the parietal cortical areas of the superior lobule involved in both multiplications and additions detected with electro-stimulation perfectly corresponded to those preoperatively shown by fMRI (Fig. 1f). The correspondence was both for sites and involved functions. Two considerations arise from our report: first, the potential capacity of fMRI to predict sites functional for calculation then detectable with intra-operative electro-stimulation. This concordance between preoperative and intra-operative findings has never reported in literature so far. Even if we must keep in mind that calculation processing is a complex function not completely understood yet, our present experience, and previous studies [1, 2] suggest

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Functional mapping of left parietal areas involved in simple addition and multiplication. A single‐case study of qualitative analysis of errors

Cited by 8 publications

References 11 publications

Causal role of the posterior parietal cortex for two-digit mental subtraction and addition: A repetitive TMS study

Causal role of the posterior parietal cortex for two-digit mental subtraction and addition: A repetitive TMS study

The brain lateralization and development of math functions: progress since Sperry, 1974

Functional MRI and calculation processing: considerations on preliminary experience about intra-operative validation by electro-stimulation

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