We recently reported our experience on functional mapping for calculation processing [1][2][3]. The numerical processing is a crucial function in daily life and its preservation can be achieved in patients undergoing neurosurgery. Indeed, it is well known the role of functional magnetic resonance imaging (fMRI) in surgical planning in patients affected by a brain tumor located in an eloquent area [4,5] as well as in the detection of structural and functional brain changes in patients with Parkinson's disease [6]. However, the fMRI reliability to detect functional sites for calculation in these patients is unclear because we are currently lacking of data on the correspondence between preoperative fMRI and intra-operative findings. A 47-year-old male patient affected by a small right parietal brain tumor recently came to our attention (Fig. 1a, b). Preoperatively, the patient underwent fMRI (3T Ingenia Philips scanner) with 16-s blocks of single-digit additions or multiplications and a control counting task. We focused on both one-digit addition and multiplication because they are the most basic of calculation tasks and their sparing is intuitively essential to perform higher order calculation.The fMRI showed some functional sites for calculation in the right superior lobule of the parietal cortex: three sites involved in addition (Fig. 1c, d) were shown just anteriorly [1, 2] and laterally [3] to the tumor; 1 site involved in multiplication (Fig. 1e) was shown just medially to the tumor. The patient then underwent the surgical resection of the parietal tumor. The approach and intra-operative mapping were performed as previously described [1,2]. The same calculation tasks used for fMRI were administered during surgery. Remarkably, we intra-operatively noted that the parietal cortical areas of the superior lobule involved in both multiplications and additions detected with electro-stimulation perfectly corresponded to those preoperatively shown by fMRI (Fig. 1f). The correspondence was both for sites and involved functions. Two considerations arise from our report: first, the potential capacity of fMRI to predict sites functional for calculation then detectable with intra-operative electro-stimulation. This concordance between preoperative and intra-operative findings has never reported in literature so far. Even if we must keep in mind that calculation processing is a complex function not completely understood yet, our present experience, and previous studies [1, 2] suggest
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