Functional magnetic resonance imaging of sensorimotor transformations in saccades and antisaccades

Herweg, Nora A.; Weber, Bernd; Kasparbauer, Anna-Maria; Meyhöfer, Inga; Steffens, Maria; Smyrnis, Nikolaos; Ettinger, Ulrich

doi:10.1016/j.neuroimage.2014.08.033

Cited by 23 publications

(21 citation statements)

References 119 publications

(207 reference statements)

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“…Hence, antisaccade latencies did not decrease but increase from low to high antisaccade frequency (Pierce & McDowell, 2016;Pierce et al, 2015). Varying target eccentricities are known to increases antisaccade latencies, antisaccade gain and antisaccade spatial error and have no effect on prosaccade metrics (Herweg et al, 2014). By contrast, the frequency manipulation facilitated antisaccade programming in Massen (2004) and in our study, both of which employed fixed target eccentricities.…”

Section: Behavioral Resultscontrasting

confidence: 48%

“…LIP receives inputs from different sources, amongst them eye position, head position and gaze position and converts them into coordinate frames to create an abstract representation of space in order to plan and guide movements (Andersen, Snyder, & Bradley, 1997). Accordingly, LIP/IPS is involved in processes of visual motor integration in saccadic eye movements, in eye movement planning and coding of spatial locations (Andersen, Brotchie, & Mazzoni, 1992;Herweg et al, 2014;Paré & Dorris, 2011). …”

Section: Condition By Frequency Interactionmentioning

confidence: 99%

“…In the antisaccade task, parietal activations during the planning phase code the remembered saccade target location (Medendorp, Goltz, & Vilis, 2005) and perform vector inversion (Gottlieb & Goldberg, 1999;Herweg et al, 2014;Zhang & Barash, 2004). Brown, Goltz, Vilis, Ford, and Everling (2006) attribute stronger parietal activations in antisaccades to the compensation of increased task difficulty as a consequence of conflicting demands to inhibit the prepotent prosaccade and to initiate a volitional saccade to the mirrored stimulus location as well as of higher attentional demands in antisaccades compared to prosaccades.…”

Section: Condition By Frequency Interactionmentioning

confidence: 99%

See 2 more Smart Citations

Facing competition: Neural mechanisms underlying parallel programming of antisaccades and prosaccades

Talanow

Kasparbauer

Steffens

et al. 2016

Brain and Cognition

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Section: Behavioral Resultscontrasting

confidence: 48%

Section: Condition By Frequency Interactionmentioning

confidence: 99%

Section: Condition By Frequency Interactionmentioning

confidence: 99%

See 1 more Smart Citation

Facing competition: Neural mechanisms underlying parallel programming of antisaccades and prosaccades

Talanow

Kasparbauer

Steffens

et al. 2016

Brain and Cognition

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“…In (previously cued) prosaccade trials participants are required to make a saccade towards the stimulus, while in antisaccade trials participants are required to perform a saccade to the mirror symmetrical position. While a prosaccade is a direct sensorimotor transformation, it has been suggested that correct performance in antisaccade trials requires additional higher cognitive processes compared to the (more reflexive) prosaccade trials (Herweg et al, 2014; McDowell et al, 2008; Munoz and Everling, 2004). During antisaccade trials participants first have to inhibit the reflexive response to look towards the visual target and then transform the stimulus location into an endogenous volitional response to the contralateral side (Munoz and Everling, 2004).…”

Section: Introductionmentioning

confidence: 99%

Different involvement of subregions within dorsal premotor and medial frontal cortex for pro- and antisaccades

Cieslik

Seidler

Laird

et al. 2016

Neuroscience & Biobehavioral Reviews

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The antisaccade task has been widely used to investigate cognitive action control. While the general network for saccadic eye movements is well defined, the exact location of eye fields within the frontal cortex strongly varies between studies. It is unknown whether this inconsistency reflects spatial uncertainty or is the result of different involvement of subregions for specific aspects of eye movement control. The aim of the present study was to examine functional differentiations within the frontal cortex by integrating results from neuroimaging studies analyzing pro- and antisaccade behavior using meta-analyses. The results provide evidence for a differential functional specialization of neighboring oculomotor frontal regions, with lateral frontal eye fields (FEF) and supplementary eye field (SEF) more often involved in prosaccades while medial FEF and anterior midcingulate cortex (aMCC) revealed consistent stronger involvement for antisaccades. This dissociation was furthermore mirrored by functional connectivity analyses showing that the lateral FEF and SEF are embedded in a motor output network, while medial FEF and aMCC are integrated in a multiple demand network.

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“…Functional localizations were identified from previous literature (Dieterich et al, 2009;Herweg et al, 2014;Meyhöfer et al, 2015;Nagel et al, 2012).…”

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confidence: 99%

Neural effects of methylphenidate and nicotine during smooth pursuit eye movements

et al. 2016

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Citation for published version (APA):Kasparbauer, A-M., Meyhöfer, I., Steffens, M., Weber, B., Aydin, M., Kumari, V., ... Ettinger, U. (2016). Neural effects of methylphenidate and nicotine during smooth pursuit eye movements. NeuroImage. DOI: 10.1016DOI: 10. /j.neuroimage.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT AbstractIntroduction: Nicotine and methylphenidate are putative cognitive enhancers in healthy and patient populations. Although they stimulate different neurotransmitter systems, they have been shown to enhance performance on overlapping measures of attention. So far, there has been no direct comparison of the effects of these two stimulants on behavioural performance or brain function in healthy humans. Here, we directly compare the two compounds using a wellestablished oculomotor biomarker in order to explore common and distinct behavioural and neural effects. Methods: Eighty-two healthy male non-smokers performed a smooth pursuit eye movement task while lying in an fMRI scanner. In a between-subjects, double-blind design, subjects either received placebo (placebo patch and capsule), nicotine (7mg nicotine patch and placebo capsule), or methylphenidate (placebo patch and 40mg methylphenidate capsule).Results: There wer...

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Functional magnetic resonance imaging of sensorimotor transformations in saccades and antisaccades

Cited by 23 publications

References 119 publications

Facing competition: Neural mechanisms underlying parallel programming of antisaccades and prosaccades

Facing competition: Neural mechanisms underlying parallel programming of antisaccades and prosaccades

Different involvement of subregions within dorsal premotor and medial frontal cortex for pro- and antisaccades

Neural effects of methylphenidate and nicotine during smooth pursuit eye movements

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