Functional long circulating single walled carbon nanotubes for fluorescent/photoacoustic imaging-guided enhanced phototherapy

Abstract

Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabricated through a new SWCNT dispersion agent, evans blue (EB). The complex was endowed with fluorescent imaging and photodynamic therapy ability by self-assembly loading an albumin coupled fluorescent photosensitizer, Chlorin e6 (Ce6) via the high affinity between EB and albumin. The yielding multifunctional albumin/Ce6 loaded EB/carbon nanotube-based delivery system, named ACEC, is capable of providing fluorescent and photoacoustic imaging of tumors for optimizing therapeutic time window. Synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) were carried out as guided by imaging results at 24 h post-injection and achieved an efficient tumor ablation effect. Compared to PDT or PTT alone, the combined phototherapy managed to damage tumor and diminish tumor without recurrence. Overall, our study presents a SWCNT based theranostic system with great promising in dual modalities imaging guided PTT/PDT combined treatment of tumor. The applications of EB on SWCNT functionalization can be easily extended to the other nanomaterials for improving their in vivo stability and circulation time.

Phase-Transition Nanodroplets for Real-Time Photoacoustic/Ultrasound Dual-Modality Imaging and Photothermal Therapy of Sentinel Lymph Node in Breast Cancer

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“…Moreover, the CNPs have photothermal-conversion effect after exposure to laser. Photothermal therapy is highly effective in oncotherapy43233. In this study, we have shown that CNPs has the therapeutic effect on the tumor, as demonstrated both in vitro and in vivo .…”

A Smart Responsive Dual Aptamers‐Targeted Bubble‐Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging

“…Therefore, the combination of chemotherapy, PTT, and biotherapy was applied to improve the efficacy of tumor treatments. Xie et al reported that synergistic photodynamic therapy and PTT of Chlorin e6‐loading SWCNTs achieved an efficient tumor ablation effect …”

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

“…These materials, usually in a nanoscale range, can be classified as organic nanoparticles (lipids, polymers, liposomes, polymeric micelles, dendrimers, and engineered peptides and nucleic acids) and inorganic nanoparticles (carbon nanoparticles, metal and metal oxide nanoparticles) [4][5][6][7][8] ( Figure 1). In comparison with conventional chemotherapy, nanoparticle drug carriers offer the optimized drug formulations and improved pharmacokinetics to deliver drugs into tumors while reducing systemic toxicity.…”