2020
DOI: 10.1101/2020.08.31.276717
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Functional insights from KpfR, a new transcriptional regulator of fimbrial expression that is crucial for Klebsiella pneumoniae pathogenicity

Abstract: Although originally known as an opportunistic pathogen, Klebsiella pneumoniae has been considered a worldwide health threat nowadays due to the emergence of hypervirulent and antibiotic-resistant strains capable of causing severe infections not only on immunocompromised patients but also on healthy individuals. Fimbriae is an essential virulence factor for K. pneumoniae, especially in urinary tract infections, because it allows the pathogen to adhere and invade urothelial cells and to form biofilms on biotic a… Show more

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Cited by 2 publications
(2 citation statements)
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References 46 publications
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“…The function of type 1 fimbriae is mainly adhesion especially in UTI, while type 3 fimbriae are necessary for biofilm formation. Type 1 fimbriae contain an adhesin molecule (FimH) that binds to bladder cells surface (8) , as a result, the uropathogen replicates intracellularly effortlessly.…”
Section: Fimbriaementioning
confidence: 99%
“…The function of type 1 fimbriae is mainly adhesion especially in UTI, while type 3 fimbriae are necessary for biofilm formation. Type 1 fimbriae contain an adhesin molecule (FimH) that binds to bladder cells surface (8) , as a result, the uropathogen replicates intracellularly effortlessly.…”
Section: Fimbriaementioning
confidence: 99%
“…(Russo & Marr, 2019). Diverse virulence factors such as siderophores, capsular polysaccharides, lipopolysaccharides, and fimbrial adhesins contribute to the pathogenicity of K. pneumoniae (Remya et al, 2019; Gomes et al, 2021). Moreover, the propensity of K. pneumoniae to acquire multidrug resistance has made them more notorious to deal with in the hospital environment.…”
Section: Introductionmentioning
confidence: 99%