Functional Indicators for Assessing Zinc Deficiency

Walker, Christa L. Fischer; Black, Robert E.

doi:10.1177/15648265070283s305

Cited by 53 publications

(33 citation statements)

References 88 publications

(104 reference statements)

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“…Estudos sobre a suplementação de zinco têm mostrado efeitos positivos sobre os desfechos clínicos e o crescimento, especialmente entre crianças com o crescimento afetado 31,32 . Hambidge et al 22 consideraram que a necessidade de zinco para crianças com doença hepática deveria ser cerca de 40% maior do que aquela considerada para crianças saudáveis.…”

Section: Discussionunclassified

Low plasma zinc concentrations in pediatric patients with cirrhosis

Schneider¹,

Pinto²,

Fröehlich³

et al. 2009

J Pediatr (Rio J)

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Objective: To determine plasma zinc concentrations in children and adolescents with cirrhosis and to investigate the association between these results and dietary zinc intake, anthropometric data, and severity of liver disease.Methods: Plasma zinc concentration was assessed by atomic absorption spectrophotometry in 30 children and adolescents with cirrhosis (105.0±60.0 months; 22 girls) and 27 without liver disease (122.3±47.3 months, 14 girls). Dietary zinc data were evaluated by 3-day food intake records. Anthropometry measures included height, weight, skinfold thickness, brachial circumference, and upper arm muscle size. Severity of liver disease was classified according to the Child-Pugh, MELD, and PELD criteria. Results:The mean (± standard deviation) plasma zinc concentrations in control subjects and patients were 105.69±19.46 and 75.44±24.45 µg/dL, respectively (p < 0.001). No associations were found between anthropometric measures, dietary zinc intake, and plasma zinc concentration. There was statistical difference related to plasma zinc concentrations between Child-Pugh B + C patients and control subjects (p < 0.001), and concerning PELD, between patients below the cutoff score of 15 and those above (p = 0.002). Conclusions:The prevalence of hypozincemia was 43% for patients with cirrhosis. Although low plasma zinc concentration was associated with more severe liver disease, it was present even in some Child-Pugh A patients. Therefore, zinc supplementation should be considered for cirrhotic children.J Pediatr (Rio J). 2009;85(4):359-364: Zinc, liver cirrhosis, anthropometry, child. ResumoObjetivo: Determinar a concentração plasmática de zinco em crianças e adolescentes cirróticos e investigar a associação entre esses resultados e a ingestão dietética de zinco, os dados antropométricos e a gravidade da doença hepática.Métodos: As concentrações plasmáticas de zinco foram avaliadas por espectrofotometria de absorção atômica em 30 crianças e adolescentes com cirrose (105,0±60,0 meses; 22 meninas) e 27 hígidas e sem doença hepática (122,3±47,3 meses, 14 meninas). Os dados relacionados ao zinco dietético foram avaliados por registro de ingestão alimentar de 3 dias. A antropometria incluiu peso, altura, espessura da dobra cutânea, circunferência braquial e área muscular do braço. A gravidade da doença hepática foi classificada de acordo com os critérios de Child-Pugh, MELD e PELD. Resultados: As concentrações plasmáticas de zinco dos indivíduos controles e dos pacientes foram 105,69±19,46 e 75,44±24,45 µg/dL, respectivamente (p < 0,001). Nenhuma associação foi encontrada entre os índices antropométricos, a ingestão dietética e o zinco plasmático. Houve diferença estatística nas concentrações de zinco plasmático entre pacientes Child-Pugh B+C e controles (p < 0,001), e com relação ao PELD, entre pacientes abaixo e acima do ponto de corte 15 (p = 0,002). Conclusão:A prevalência de hipozincemia foi de 43% para pacientes com cirrose. A baixa concentração plasmática de zinco foi associada com a doença hepát...

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Section: Discussionunclassified

Low plasma zinc concentrations in pediatric patients with cirrhosis

Schneider¹,

Pinto²,

Fröehlich³

et al. 2009

J Pediatr (Rio J)

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show abstract

“…25 Trials of zinc supplementation have shown positive effects on clinical outcomes and growth, especially among children who are stunted. 31,32 Hambidge et al, 22 studying children with biliary atresia, considered that the zinc requirement for net absorption would be 40% greater than that of healthy infants. Considering that the liver impairment affects the zinc metabolism and absorption of dietetic zinc, we believe that zinc supplementation could improve the zinc status of these patients.…”

Section: Discussionmentioning

confidence: 99%

Baixas concentrações plasmáticas de zinco em pacientes pediátricos com cirrose

Schneider¹,

Pinto²,

Fröehlich³

et al. 2009

J. Pediatr. (Rio J.)

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“…To better identify population zinc deficiency among children, national stunting prevalence rates can also be used as a proxy indicator (Fischer Walker and Black, 2007). There have been more than 28 supplementation trials assessing the effect of zinc on growth.…”

Section: Methodsmentioning

confidence: 99%

“…The magnitude of the effect size of zinc on height is dependent upon the baseline height for age Z score (HAZ) score of the population and thus zinc has a greater effect on linear growth when given in populations with the mean HAZ oÀ2. Using this data, it is recommended that childhood stunting prevalence rates X20% serve as a proxy for identifying population zinc deficiency among children under 5 years of age (Fischer Walker and Black, 2007).…”

Section: Methodsmentioning

confidence: 99%