“…In addition, haplotype relative risk (HRR) analyses showed that these same SNP alleles were more often transmitted to patients (HRR = 1.568, P < 0.014 for the 2093C allele; HRR = 2.114, P < 0.001 for the 2180T allele) [Li YJ et al, 2004]. The same group using a similar approach recently reported that the Megsin 23167G SNP variant is associated with both susceptibility and progression of IgAN in 435 Chinese patients and their family members using TDT and HRR analyses [Takei et al, 2006]. The GG genotype was found to be associated with severe histologic lesions and disease progression.…”